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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.

n/a --- tissue engineering --- microfluidic device --- ischemia/reperfusion injury --- syringe pump --- liver-on-a-chip --- vacuum chuck --- epithelial–endothelial interface --- vessel branching --- organs-on-chips --- nanogrooves --- passive delivery --- functional neuron imaging --- organ-on-a-chip --- lung epithelial cell --- MEMS --- drug absorption --- strain --- 3D cell culture system --- mechanical cue --- multi-culture --- angiogenesis --- high-throughput screening --- fluoroelastomer --- membranes --- cell culture --- paracellular/transcellular transport --- beating force --- microfabrication --- drug hepatotoxicity --- biomimetic oxidation --- compression --- microfluidics --- surfactant protein --- PDMS --- neuronal cell networks --- neuronal guidance --- trans-epithelial electrical resistance --- spheroid array --- organ-on-a-chip (OOC) --- biomechanics --- cell --- organ-on-chips --- organ-on-chip --- stretch --- shear stress --- shear flow --- image-based screening --- drug metabolism --- vascularization --- human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) --- stress --- barrier permeability --- bio-mechanical property --- cardiac 3D tissue --- endothelial cell activation --- organoid --- silicon --- lattice light-sheet microscopy --- integrated pump --- SH-SY5Y cells --- thrombolysis --- 3D cell culture --- neuronal cells --- drug efficacy --- vascularized tumor model --- epithelial-endothelial interface