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This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

Biological models. --- Systems biology. --- Gene regulatory networks --- Physiology. --- Circuits, Gene --- Gene circuits --- Gene modules --- Gene networks --- Genetic regulatory networks --- GRNs (Gene regulatory networks) --- Modules, Gene --- Networks, Gene regulatory --- Networks, Transcriptional --- Regulatory networks, Gene --- Transcriptional networks --- Genetic regulation --- Nucleotide sequence --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Models, Biological --- Microbial genetics. --- Microbial genomics. --- Bioinformatics. --- Systems Biology. --- Microbial Genetics and Genomics. --- Mathematical Modeling and Industrial Mathematics. --- Computational Biology/Bioinformatics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Systems biology --- Genomics --- Microbial genetics --- Microorganisms --- Genetics --- Microbiology --- Data processing --- Mathematical models. --- Models, Mathematical --- Simulation methods

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In this text, Roger Sansom investigates how gene regulation works and how such a refined but simple system evolved. Sansom describes in detail two frameworks for understanding gene regulation.

Genetic regulation -- Computer simulation. --- Genetic regulation --- Gene regulatory networks --- Biological Evolution --- Genetic Processes --- Regulatory Sequences, Nucleic Acid --- Base Sequence --- Biological Processes --- Genetic Phenomena --- Biological Phenomena --- Genetic Structures --- Phenomena and Processes --- Evolution, Molecular --- Gene Regulatory Networks --- Gene Expression Regulation --- Biology --- Health & Biological Sciences --- Genetics --- Computer simulation --- Computer simulation. --- Gene expression --- Gene expression regulation --- Gene regulation --- Regulation --- Gene regulatory networks. --- Evolution, Molecular. --- Gene Regulatory Networks. --- Gene Expression Regulation. --- Circuits, Gene --- Gene circuits --- Gene modules --- Gene networks --- Genetic regulatory networks --- GRNs (Gene regulatory networks) --- Modules, Gene --- Networks, Gene regulatory --- Networks, Transcriptional --- Regulatory networks, Gene --- Transcriptional networks --- Nucleotide sequence --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Module --- Gene Circuits --- Gene Modules --- Gene Networks --- Transcriptional Networks --- Circuit, Gene --- Gene Circuit --- Gene Network --- Gene Regulatory Network --- Module, Gene --- Network, Gene --- Network, Gene Regulatory --- Network, Transcriptional --- Networks, Gene --- Networks, Gene Regulatory --- Regulatory Network, Gene --- Regulatory Networks, Gene --- Transcriptional Network --- Protein Interaction Maps --- Genetic Evolution --- Molecular Evolution --- Evolution, Genetic --- Directed Molecular Evolution --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- PHILOSOPHY/Philosophy of Science & Technology --- BIOMEDICAL SCIENCES/General

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Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.--

Nervous system --- Nervous System Diseases --- Genetic Therapy --- Gene Expression Regulation. --- Diseases --- Gene therapy. --- therapy. --- methods. --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Organs (Anatomy) --- Neurosciences

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Emphasizing exciting recent developments in the study of gene structure and transcription processes, this compares and contrasts euykaryotic and prokaryotic gene structure, transcription apparatus and regulation of transcription at molecular level.

Genetic transcription --- Transcription, Genetic --- Transcription génétique --- Genetic transcription. --- Gene Expression Regulation --- Genetic Transcription --- DNA, Ribosomal --- Antisense Elements (Genetics) --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Transcription (Genetics) --- Genetic code --- Organisms --- Genes

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Biotechnology --- Gene regulatory networks --- Genomics --- Research --- Systems biology --- Genómica --- Gene Regulatory Networks --- Research Support as Topic --- Systems Biology --- Systems Theory --- Government policy --- Investigación --- Genomics. --- Human Genome Project --- Genome --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Science --- Science research --- Scientific research --- Information services --- Learning and scholarship --- Methodology --- Research teams --- Genome research --- Genomes --- Molecular genetics --- Circuits, Gene --- Gene circuits --- Gene modules --- Gene networks --- Genetic regulatory networks --- GRNs (Gene regulatory networks) --- Modules, Gene --- Networks, Gene regulatory --- Networks, Transcriptional --- Regulatory networks, Gene --- Transcriptional networks --- Genetic regulation --- Nucleotide sequence --- Chemical engineering --- Genetic engineering --- Seventh Framework Programme (European Commission) --- Sixth Framework Programme (European Commission) --- European Commission. --- EU's Framework Programme for Research and Technological Development --- European Community Framework Programme for Research, Technological Development, and Demonstration --- FP6 --- Sixth FP (European Commission) --- 6. RP --- Sechstes Rahmensprogramm (European Commission) --- Sexto Programa Marco (European Commission) --- 6e programme-cadre (European Commission) --- Sixième programme-cadre (European Commission) --- Sesto programma quadro (European Commission) --- Sixth Framework Programme for Research & Technological Development --- Sixth Framework Research Programme (European Commission) --- Sjette rammeprogram for forskning (European Commission) --- Sjette rammeprogrammet (European Commission) --- Zesde kaderprogramma voor onderzoek van de EU --- Zesde kaderprogramma (European Commission) --- Kuudes tutkimuksen puiteohjelma (European Commission) --- Kuudes puiteohjelma (European Commission) --- 6o Programa-Quadro de Investigação da UE --- Sexto Programa-Quadro de Investigação da UE --- Sexto Programma Quadro (European Commission) --- Sjätte ramprogram för forskning (European Commission) --- Sjätte ramprogrammet (European Commission) --- Seventh Framework Programme for Research and Technological Development --- Framework 7 (European Commission) --- Framework Seven (European Commission) --- FP7 --- Seventh Research Framework Programme (European Commission) --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative