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Antibiotics. --- Mycobacterium. --- Streptomyces.
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This dissertation by Daniel Eklund explores the interaction between Mycobacterium tuberculosis and human macrophages, focusing on inflammasome activation, particularly the role of the NLRP3 inflammasome. Tuberculosis remains a global health threat, exacerbated by antibiotic resistance and its association with HIV. The research examines how the activation of NLRP3 in macrophages infected with M. tuberculosis enhances the immune response, promoting bacterial eradication. Key findings include the role of vitamin D in increasing IL-1β production, thereby improving macrophage efficacy. The study suggests that manipulating inflammasome activity could shift the balance in favor of the host, providing new insights into potential therapeutic strategies against tuberculosis.
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This dissertation by Clara Braian explores the innate immune responses to Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB). It examines how innate immune cells, such as macrophages and neutrophils, respond to TB infection and how they can limit bacterial growth through mechanisms like extracellular trap formation and trained immunity. The work highlights the role of extracellular traps in capturing the bacteria and the influence of β-glucans in enhancing the immune response. The research utilizes both in vitro models and advanced tissue models to study the interactions between immune cells and the pathogen. The goal is to improve understanding of the immune response to TB and to inform potential new treatments. The intended audience includes medical researchers and healthcare professionals interested in infectious diseases and immunology.
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579.873.21 --- Mycobacterium --- Theses --- 579.873.21 Mycobacterium
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