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This book reprints Human Guinea Pigs, by Kenneth Mellanby, a seminal work in the history of medical ethics and human subject research that has been nearly unavailable for over 40 years. Detailing the use of World War II conscientious objectors who volunteered for experimentation on scabies transmission, Mellanby’s book offers insight into one approach to human subject experimentation before the development of ethical oversight regulations. His work was initially published prior to the articulation of the Nuremberg Code, which makes his subsequent position as a reporter for the British Medical Journal at the Nuremberg Trials very interesting, particularly given his sometimes controversial opinions on Nazi medical experimentation. This book reprints the second edition together with commentary essays that situate Mellanby’s ethical approach in historical context and relative to contemporary approaches. This volume is of particular interest to scholars of the history of human subject research.
Scabies. --- Human scabies --- Itch (Disease) --- Mange --- Seven-year itch (Disease) --- Ectoparasitic infestations --- Bioethics. --- Medicine—History. --- History of Medicine. --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Science --- Moral and ethical aspects
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This latest book in the Clinical Cases in Dermatology series presents a variety of cases of pruritus. A clear easy-to-follow chapter structure throughout the work enables the reader to develop a thorough understanding of the content covered in each case. An emphasis is placed on key features that distinguish pruritus from other conditions to ensure the reader develops their diagnostic skills. Practically applicable guidance on how to appropriately manage the disorder to assist the reader in the clinical decision-making is also provided. Clinical Cases in Pruritus is a concise practically applicable resource detailing how to diagnose and manage pruritus in a variety of scenarios. Therefore, it is of interest to practicing and trainee dermatologists seeking a concise up-to-date resource on the topic.
Dermatology. --- Medicine --- Skin --- Diseases --- Itching. --- Itch --- Itches --- Pruritus --- Cutaneous manifestations of general diseases --- Senses and sensation --- Pruïja --- Històries clíniques --- Casos --- Casos clínics --- Historials clínics --- Informes mèdics --- Protocols clínics --- Registres d'infermeria --- Manifestacions cutànies de les malalties
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Insect pests. --- Beneficial insects. --- Plant mites. --- Agricultural pests. --- 632.7 --- 595.7 --- 595.42 --- Insect pests --- Beneficial insects --- Plant mites --- Agricultural pests --- #ABIB:afyt --- Crop pests --- Crops --- Pests --- Crop losses --- Plant quarantine --- Plants --- Mites --- Plant parasites --- Economic entomology --- Entomology, Economic --- Insects, Beneficial --- Insects, Injurious and beneficial --- Useful insects --- Insects --- Zoology, Economic --- Destructive insects --- Injurious insects --- Arthropod pests --- Veterinary entomology --- Insects injurious to plants --- Insecta (Hexapoda). Insects. Entomology --- Acarina. Mites. Soil-mites. Itch-mites. Ticks. Sheep- tick. Fowl-tick etc. --- Diseases and pests --- Wounds and injuries --- 595.42 Acarina. Mites. Soil-mites. Itch-mites. Ticks. Sheep- tick. Fowl-tick etc. --- 595.7 Insecta (Hexapoda). Insects. Entomology --- 632.7 Insects injurious to plants --- Plant and Crop Sciences Agricultural Entomology and Acarology -- Agricultural Entomology and Acarology --- ALLW. --- Acarina. Mites. Soil-mites. Itch-mites. Ticks. Sheep- tick. Fowl-tick etc --- Plant and Crop Sciences Agricultural Entomology and Acarology -- Agricultural Entomology and Acarology.
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This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource for all physicians confronted with patients suffering from itch. The Editors have recruited a board of internationally renowned experts to provide an in-depth analysis of the causes and management of pruritus, including the current concepts in pathophysiology and novel therapeutics. Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a manifestation of dermatologic and non-dermatologic diseases. All patients suffering from itch know that it is a very awkward sensation. Unfortunately, this often significant symptom is frequently considered less severe in comparison with pain. The consequences are that research on this field has been poorer than research on pain and that pruritus is therefore more difficult to treat. Pruritus, Second edition addresses the new concepts and discoveries that have modified our understanding of this condition. It explains the pathophysiology of itch, describes all causes, and provides guidelines for management and treatment.
Medicine. --- Dermatology. --- General practice (Medicine). --- Infectious diseases. --- Primary care (Medicine). --- Epidemiology. --- Medicine & Public Health. --- Infectious Diseases. --- Primary Care Medicine. --- General Practice / Family Medicine. --- Itching --- Etiology. --- Treatment. --- Itch --- Itches --- Pruritus --- Emerging infectious diseases. --- Emergency medicine. --- Family medicine. --- Diseases --- Public health --- Medicine --- Skin --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Primary medical care --- Medical care
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This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists involved in both basic and clinical work relevant to the research and treatment of pain and/or itch.
Neurology --- Medicine --- Health & Biological Sciences --- Pain. --- Itching. --- Itch --- Itches --- Pruritus --- Aches --- Cutaneous manifestations of general diseases --- Senses and sensation --- Emotions --- Pleasure --- Symptoms --- Analgesia --- Suffering --- Neurosciences. --- Human physiology. --- Medicine. --- Pain Medicine. --- Human Physiology. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Molecular biology. --- Pain medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Algiatry
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Pseudorabies virus (PRV) is an important swine pathogen that impacts swine industry worldwide. PRV belongs to the alphaherpes virus subfamily of the herpesviruses that has been widely used as a model herpes virus. Most recently, PRV has been reported sporadically spillover into human and other animals. This book collects the newest advances in the field of pseudorabies virus research, including critical reviews and research on viral evolution, replication, virus–host interaction, pathogenesis and immunity, and novel antiviral strategies.
Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- pseudorabies virus --- Liver X receptors --- clathrin-coated pits --- viral entry --- innate immune response --- type I interferons --- apoptosis --- autophagy --- premature termination codon --- genetic code expansion --- virus isolation --- pathogenicity --- mortality --- inflammatory response --- Huaier polysaccharide --- antiviral --- infection --- Vero cell --- TMT-based proteomic analysis --- differentially expressed proteins --- antiviral breeding --- genetic modification --- nectin1 --- pig --- PRV --- disease resistance --- seroprevalence --- epidemiology --- phylogenetic analysis --- variants --- ICP0 protein --- P65 --- NF-κB signaling pathway --- complete genome sequencing --- gene recombination --- variant strain --- genomics --- vaccination --- transmission --- zoonosis --- itch --- mouse --- histamine --- dorsal root ganglion --- metabolomic analysis --- UHPLC-QE-MS --- PK-15 cells --- latent infection --- latency-associated transcripts --- non-coding RNA --- latency --- miRNA --- chromatin --- immune regulation --- variation --- human pseudorabies encephalitis --- pseudorabies virus (PRV) --- tegument protein UL13 --- RIG-I --- MDA5 --- NF-κB --- pathogenesis --- prevention and control --- Aujeszky’s disease --- epidemiological characteristics
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