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ISBN: 0898383706 0585280061 Year: 1988 Publisher: Dordrecht, the Netherlands ; Strasbourg, France : Kluwer Academic Publishers : Council of Europe,
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In 1986, the Committee of Experts on Blood Transfusion and Immunohae- tology of the Council of Europe chose for their Programme of Co-ordinated Research "An investigation of the procurement and sharing of transplantable organs for potential recipients who are highly sensitized to HLA-antigens". This topic was of common concern to all centres practising renal transplan- tion. The terms of reference of the study were: To estimate the number of patients who are virtually "untransplantable" because of high sensitization in each European country. To study the nature of immunization in terms of the type and specificity of antibodies present in the blood and techniques used for their detection. To investigate possible practical solutions - both current and future, invo- ing cross-matching procedures, the circulation of reference material from patients, and the willingness of the national organizations to share resources. 4. To explore other methods of resolving this problem. Although the study did not offer the prospect of a brilliant new insight into the problem of high sensitization, it was unique in several ways: for the first time we saw all European organizations collaborating in a common project to provide information on their activities, their problems and the methods to resolve them; it introduced, for this subject, relatively novel statistical methods to investigate susceptibility to sensitization and factors affecting transplant outcome; it enabled a large database of transplanted highly sensitized patients and matched controls to be assembled, that would have been unavailable as a research resource at any single centre.
Kidneys --- Graft survival. --- Hla antigens. --- Kidney --- Transplantation immunology. --- Transplantation --- Immunological aspects. --- Transplantation. --- HLA histocompatibility antigens. --- Medicine. --- Immunology. --- Nephrology. --- Surgery. --- Medicine & Public Health.
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ISBN: 3319543105 3319543091 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,
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In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
Hematopoietic stem cells --- Hematopoietic stem cell disorders --- Transplantation. --- Treatment. --- Medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Tumors --- Haematology --- Internal medicine --- Blood --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Hematopoietic stem cell diseases --- Oncology . --- Transplantation, Haploidentical --- Transplantation Tolerance. --- methods --- adverse effects --- Allograft Tolerance --- Graft Tolerance --- Tolerance, Allograft --- Tolerance, Graft --- Tolerance, Transplantation --- Graft Survival
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