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Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.

Cancer --- Immunological aspects. --- Carcinogenesis --- Immunological aspects --- Interleukin-1 --- Neoplasms --- Immunotherapy --- Tumor Microenvironment --- Immunology. --- immunology --- Interleukin-1. --- Immunotherapy. --- Tumor Microenvironment. --- immunology.

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"Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters."--

Host-bacteria relationships. --- Bacteria-host relationships --- Relationships, Host-bacteria --- Host-parasite relationships --- Immune system. --- Microbial ecology. --- Cancer --- Host Microbial Interactions --- Microbiota --- Tumor Microenvironment --- Immunological aspects. --- immunology --- Host Microbial Interactions. --- Tumor Microenvironment. --- immunology.

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"Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches."--

Gas reservoirs. --- Gas pools --- Natural gas reservoirs --- Pools, Gas --- Reservoirs, Gas --- Hydrocarbon reservoirs --- Natural gas --- Geology --- Breast --- Cancer --- Treatment. --- Cancer. --- Drug targeting. --- Breast Neoplasms --- Nanoparticle Drug Delivery System --- Tumor Microenvironment --- Chemotherapy. --- drug therapy --- Nanoparticle Drug Delivery System. --- Tumor Microenvironment. --- drug therapy.

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Connective Tissue Cells --- Carcinoma --- Endocrine Gland Neoplasms --- Digestive System Neoplasms --- Pancreatic Diseases --- Cell Physiological Phenomena --- Phenomena and Processes --- Digestive System Diseases --- Neoplasms by Site --- Neoplasms, Glandular and Epithelial --- Cells --- Endocrine System Diseases --- Diseases --- Neoplasms by Histologic Type --- Anatomy --- Neoplasms --- Pancreatic Neoplasms --- Adenocarcinoma --- Tumor Microenvironment --- Stromal Cells --- Connective Tissue Cells. --- Carcinoma. --- Endocrine Gland Neoplasms. --- Digestive System Neoplasms. --- Pancreatic Diseases. --- Cell Physiological Phenomena. --- Digestive System Diseases. --- Neoplasms by Site. --- Neoplasms, Glandular and Epithelial. --- Cells. --- Endocrine System Diseases. --- Disease. --- Neoplasms by Histologic Type. --- Anatomy. --- Neoplasms. --- Pancreatic Neoplasms. --- Adenocarcinoma. --- Tumor Microenvironment. --- Stromal Cells.

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Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.

bleomycin --- n/a --- regeneration --- antitumor efficacy --- lung cancer --- SOX2 --- leiomyosarcoma --- lung cancer (LC) --- nanoparticles --- cytokines --- hepatocellular carcinoma --- metabolic reprogramming --- hepatic stellate cells --- angiogenesis --- transforming growth factor-? --- anaplastic lymphoma kinase --- idiopathic pulmonary fibrosis --- growth factor --- pathogenesis --- cancer-associated fibroblasts --- fibrosis --- lipopolysaccharide --- DHA --- lncRNA --- SREBP-1 --- YAP --- protein S --- non-small cell lung cancer (NSCLC) --- omega-3 fatty acid --- inflammation --- metastasis --- clinical symptoms --- miRNA --- smooth muscle tumor of uncertain malignant potential --- Wnt --- interstitial fluid pressure --- heterogeneity --- hepatocytes --- myometrium --- tumor necrosis factor ? --- tumor --- tumor microenvironment --- extracellular matrix --- TAZ --- carcinogenesis --- cystic formation --- pulmonary fibrosis --- HBV --- cytokine --- genetic instability --- diagnosis --- EMT --- crizotinib --- Hippo pathway --- GPR120 --- marker --- HCV --- non-alcoholic steatohepatitis --- pathology --- common pathways --- apoptosis --- type I collagen --- GPR40 --- acute lung injury --- uterine fibroid --- renal injury --- pathophysiology --- reactive oxygen species --- immunohistochemistry --- SMAD --- butylidenephthalide --- leiomyoma --- cirrhosis --- Erk1/2 --- targeted therapy --- TGF-? --- mechanotransduction --- therapy --- breast cancer --- hepatocellular carcinoma (HCC) --- hepatic stellate cells (HSCs) --- idiopathic pulmonary fibrosis (IPF) --- cancer-associated fibroblasts (CAFs) --- cancer --- signal pathway --- tumor stiffness