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General biophysics --- General biochemistry --- Protein-protein interactions --- #WSCH:FYS3 --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- Protein-protein interactions. --- PPIs (Protein-protein interactions) --- Interactomes --- PROTEINS --- MOLECULAR ASSOCIATION --- REACTIONS

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Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Life Sciences --- Genetics and Molecular Biology --- Chemical Biology --- Biochemistry --- Bioorganic Chemistry

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The second volume of the book-Protein-Protein Interactions (PPIs) provides an overview of various protein-protein interactions (PPIs) that are involved in various human diseases including cancer, neurodegenerative diseases, immune diseases, and inflammation. It summarizes the structure and ligand-based drug designing approaches for the discovery of small molecules that can inhibit PPIs in these diseases. The book discusses different computational and experimental tools that are used to determine the anomalous interactions underlying the diseases. Lastly, it also reviews the classical interactions between pathogens and hosts that are responsible for the pathophysiology of infectious diseases.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Bioinformatics. --- Life sciences. --- Medicine --- Biology --- Neurosciences. --- Life Sciences. --- Biomedical Research. --- Neuroscience. --- Research. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological research --- Biomedical research --- Health Workforce --- Biosciences --- Sciences, Life --- Science --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Data processing

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In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. The use of thermodynamics in biological research is used as an "energy book-keeping system.? While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the

Thermodynamics. --- Metabolism --- Biophysical Processes --- Biochemical Processes --- Models, Theoretical --- Biological Science Disciplines --- Physical Phenomena --- Molecular Probe Techniques --- Chemistry --- Biochemistry --- Protein Folding --- Protein Binding --- Protein Interaction Mapping --- Thermodynamics --- Models, Molecular --- Biochemical Phenomena --- Natural Science Disciplines --- Physical Processes --- Chemical Processes --- Metabolic Phenomena --- Investigative Techniques --- Biophysical Phenomena --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemical Phenomena --- Human Anatomy & Physiology --- Animal Biochemistry --- Health & Biological Sciences --- Protein binding. --- Protein-protein interactions. --- Interactions, Protein-protein --- Protein interactions --- Binding, Protein --- Molecular association --- Allosteric proteins --- Radioligand assay --- Chemistry, Physical and theoretical --- Dynamics --- Mechanics --- Physics --- Heat --- Heat-engines --- Quantum theory --- PPIs (Protein-protein interactions) --- Interactomes