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Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailability of drugs, is used to prevent upper gastrointestinal disorders. The author performed a clinical pharmacokinetic study in renal transplant patients to evaluate a potential interaction of MPA and pantoprazole. The bioavailability and the maximum concentration of MPA were determined with or without pantoprazole intake. An influence on the immunosuppressive effect was evaluated by measuring the target enzyme activity. Overall, no significant change in the bioavailability or the maximum concentration was found. Similar results were obtained for the target enzyme activity after pantoprazole intake with MPA. The results suggest that the interaction of pantoprazole with MPA does not compromise the immunosuppressive effect to a clinically meaningful extent. Contents Validation of an Assay for Quantification of MPA and MPAG Clinical Study of a PK Interaction of Pantoprazole and MPA Bioequivalence Analysis Target Groups Researchers and students in the fields of medicine and pharmacy Practitioners in the fields of nephrology and clinical pharmacology The Author Olesja Rissling studied pharmacy and works as a research associate at the Federal Joint Committee in the field of benefit assessment of pharmaceuticals. .

Medicine. --- Laboratory medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Laboratory Medicine. --- Mycophenolic acid. --- Drug interactions. --- Interactions, Drug --- Drugs --- Mycophenolate --- Mycophenolate mofetil --- Antirheumatic agents --- Immunosuppressive agents --- Side effects --- Toxicology. --- Medical laboratories. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Physiological effect