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Myasthenia gravis.

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Myasthenia Gravis --- Myasthenia gravis --- Myoneural junction --- Neuromuscular Junction --- Congresses. --- Diseases --- physiopathology

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Autoimmune Diseases --- Myasthenia Gravis --- Myasthenia gravis --- Myasthenic Syndromes, Congenital --- Myoneural junction --- Neuromuscular Junction --- Neuromuscular diseases --- Receptors, Cholinergic --- Thymoma --- immunology --- Pathophysiology --- physiopathology

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Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate.

Myasthenia gravis --- Diagnosis. --- Neuromuscular diseases --- Medicine --- Neurology --- Mental and Behavioural Disorders and Diseases of the Nervous System --- Health Sciences

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The third edition of this important, gold-standard title outlines a range of significant advances in the study and understanding of myasthenia gravis. The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders. In addition to several new authors and an extensive update of all chapters, this third edition includes summaries of pre-clinical research standards for autoimmune MG, along with a broad summary of MG clinical trial performance. The now greater understanding of the clinical presentation of MuSK-related MG and identification of potential new autoantigens, including LRP-4, is discussed. The development of treatment guidelines by groups in Japan, the United Kingdom, Germany, and an international consortium is also outlined. Myasthenia Gravis and Related Disorders, Third Edition, is an invaluable resource for meeting the many and varied needs of clinicians who treat patients with myasthenia gravis.

Myasthenia gravis --- Myoneural junction. --- Pathophysiology. --- Medicine. --- Immunology. --- Neurosciences. --- Respiratory organs --- Neurology. --- Medicine & Public Health. --- Pneumology/Respiratory System. --- Diseases. --- Medicine --- Nervous system --- Neuropsychiatry --- Respiratory diseases --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Diseases --- Motor end plate --- Neuromuscular end plate --- Neuromuscular junction --- Muscles --- Nerve endings --- Nerves --- Neuromuscular diseases --- Pneumology. --- Neurology . --- Respiratory organs—Diseases. --- Neuroscience.