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Methamphetamine (ice, speed, crystal, shard) has been called epidemic in the United States. Yet few communities were ready for increased use of methamphetamine by suburban women. Women on Ice is the first book to study exclusively the lives of women who use the drug and its effects on their families. In-depth interviews with women in the suburban counties of one of the largest metropolitan areas in the U.S. chronicle the details of their initiation into methamphetamine, the turning points into problematic drug use, and for a few, their escape from lives veering out of control. Their life course and drug careers are analyzed in relation to the intersecting influences of social roles, relationships, social/political structures, and political trends. Examining the effects of punitive drug policy, inadequate social services, and looming public health risks, including HIV/AIDS and hepatitis C, the book gives voice to women silenced by shame. Boeri introduces new and developing concepts in the field of addiction studies and proposes policy changes to more broadly implement initiatives that address the problems these women face. She asserts that if we are concerned that the war on drugs is a war on drug users, this book will alert us that it is also a war on suburban families.

Drug addiction --- Women drug addicts. --- Methamphetamine abuse. --- Women --- Drug addicts --- Amphetamine abuse --- Treatment. --- Drug use.

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Yaa baa, « le médicament qui rend fou ». En Thaïlande le surnom de la méthamphétamine sonne comme un avertissement, mais il n’a pas dissuadé des centaines de milliers de Thaïlandais, jeunes pour la plupart, de s’y adonner avec plus ou moins de retenue. « Drogue de travail » ou « drogue de loisir », il s’agit d’un véritable phénomène de société qui n’est pas étranger aux évolutions économiques et aux mutations culturelles qu’a connues le royaume au cours de ces dernières décennies. Ce livre s’efforce de donner des explications à un engouement qui touche également d’autres pays de la région. Il replace la consommation de méthamphétamine dans les logiques du narcotrafic dont les ressorts sont à rechercher aux marges orientales de la Birmanie, en plein cœur du Triangle d’Or.

Methamphetamine abuse --- Youth --- Drug traffic --- Drug use --- Drug dealing --- Drug production, Illicit --- Drug smuggling --- Drug trade, Illicit --- Drug trafficking --- Drugs --- Illicit drug production --- Illicit drug trade --- Narcotic trade --- Narcotic traffic --- Narcotic trafficking --- Smuggling of drugs --- Smuggling of narcotics --- Traffic, Drug --- Trafficking in drugs --- Trafficking in narcotics --- Drug abuse and crime --- Narco-terrorism --- Young people --- Young persons --- Youngsters --- Youths --- Age groups --- Life cycle, Human --- Amphetamine abuse --- Prices and sale --- Myanmar --- Southeast Asia --- narcotics --- borders --- drugs --- golden triangle --- organized crime --- Burma --- Thailand --- trafficking

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The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.

n/a --- primary cilia --- neurodegeneration --- nutrient sensor --- PI3K --- transcriptomics --- phosphorylation --- metabolic reprogramming --- autophagy --- Alzheimer’s disease --- rapalogs --- liver --- angiogenesis --- mTOR complex --- MBSCs --- advanced biliary tract cancers --- Medulloblastoma --- epithelial to mesenchymal transition --- AMPK --- p70S6K --- lipid metabolism --- thyroid cancer --- sodium iodide symporter (NIS)/SLC5A5 --- male fertility --- anesthesia --- illumina --- mTOR inhibitor --- miRNA --- Hutchinson-Gilford progeria syndrome (HGPS) --- eIFs --- Emery-Dreifuss muscular dystrophy (EDMD) --- glucose --- AKT --- oral cavity squamous cell carcinoma (OSCC) --- glucose and lipid metabolism --- cellular signaling --- aging --- tumor microenvironment --- rapamycin --- leukemia --- chloral hydrate --- rapalogues --- schizophrenia --- T-cell acute lymphoblastic leukemia --- senescence --- lamin A/C --- neurotoxicity --- neurodevelopment --- inhibitor --- methamphetamine --- pulmonary fibrosis --- mTOR --- mTOR inhibitors --- combination therapy --- proteolysis --- fluid shear stress --- tumour cachexia --- biomarkers --- synapse --- gluconeogenesis --- mTOR signal pathway --- Sertoli cells --- immunosenescence --- miRNome --- protein aggregation --- senolytics --- metabolism --- NGS --- mTORC2 --- mTORC1 --- metabolic diseases --- IonTorrent --- apoptosis --- dopamine receptor --- nocodazole --- microenvironment --- everolimus --- acute myeloid leukemia --- immunotherapy --- spermatogenesis --- bone remodeling --- signalling --- targeted therapy --- ageing --- therapy --- NVP-BEZ235 --- fructose --- physical activity --- laminopathies --- MC3T3-E1 cells --- cell signaling --- microRNA --- cancer --- lipolysis --- melatonin --- Parkinson’s disease --- Alzheimer's disease --- Parkinson's disease