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Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and biotargeting. The heart of the book presents oncological approaches (supportive, radiation, and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Surgery - General and By Type --- Surgery & Anesthesiology --- Health & Biological Sciences --- Bone metastasis. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Bones --- Metastasis --- Cancer --- Orthopedics. --- Oncology  . --- Oncology. --- Tumors --- Orthopaedics --- Orthopedia --- Surgery

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Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Bone Cancer. --- Bone Neoplasms --- therapy. --- Bones --- Bone metastasis. --- Bone Neoplasms. --- Cancer. --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis --- Cancer

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Bones --- Bone metastasis --- Cancer --- Os --- Métastases osseuses --- Diseases --- Periodicals --- Tumors --- Complications --- Maladies --- Périodiques --- Tumeurs --- Complications et séquelles --- Bone Neoplasms. --- Bone Diseases. --- Neoplasms --- complications. --- Bone Disease --- Disease, Bone --- Diseases, Bone --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Osteology --- bone oncology --- cancer --- cancer treatment --- radiotherapy --- surgery --- pharmacology --- Bone metastasis. --- Complications. --- Complications and sequelae --- Metastasis --- Musculoskeletal system --- Bone --- Skeleton --- Health Sciences --- Oncology --- Oncology. Neoplasms --- Pathology of the organs of movement --- Càncer d'ossos. --- Càncer --- Osteosarcoma