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Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Induced pluripotent stem cells. --- Induced Pluripotent Stem Cells --- Stem Cells --- Induced Pluripotent Stem Cells. --- Stem Cells.

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"[A]ddresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs uring state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine; and is contributed by world-renowned authors in the field"--Print version, page 4 of cover.

Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Pathology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Induced pluripotent stem cells. --- Pathology, Molecular. --- Pathology, Cellular. --- Induced Pluripotent Stem Cells --- Models, Molecular --- Stem Cells --- Pathology, Molecular --- Induced Pluripotent Stem Cells. --- Models, Molecular. --- Stem Cells.

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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.

nerve conduit --- tissue engineering --- regenerative medicine --- mixed lymphocyte reaction --- histological images --- future scaffold engineering --- multiparameter --- 3DPVS --- MSCs --- Wnt signaling --- Mesenchymal Stromal Cells --- factorial design --- novel scaffold --- Wharton’s Jelly tissue --- stem cells --- umbilical arteries --- SDS --- platelet rich plasma --- TGF? signaling --- traditional scaffold --- pluripotency and commitment --- tissue engineered construct --- HLA-G --- CHAPS --- platelets --- proteomic analysis --- vibrating nature of universe. --- VS55 --- cell culture --- FGF signaling --- evolution of scaffold --- dynamicity and dimensionality --- fibrin gel --- scaffold classification --- decellularization --- vitrification --- seven-folder logics --- IIEF-5 questionnaire --- TGF-?1 --- erectile dysfunction --- human induced pluripotent stem cells --- iPSCs --- scaffolds --- Barret’s esophagus --- nerve regeneration --- long term storage --- laws of system evolution --- scaffold categorization --- platelet lysate --- 3D scaffold --- esophagus --- language of relativity --- cord blood units