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Surgery --- Chirurgie --- Periodicals --- Périodiques --- MDSURGER --- surgery --- general surgery --- gastric cancer --- digestive surgery --- Surgery. --- General Surgery. --- Surgery, General --- Surgical Procedures, Operative --- Surgery, Primitive --- Medicine --- General Surgery

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Carotenoids are a group of approximately 600 compounds synthesized by photosynthetic organisms. These pigments are abundant in fruits and vegetables, as well as in certain animal products such as eggs and salmon, being responsible for their colorful appearance. The bioactive properties of certain carotenoids in human health are clear, as some of these compounds have antioxidant properties and serve as the only precursors of vitamin A in nature. The aim of this Special Issue entitled “Carotenoids and Human Health” is to provide the scientific community with an updated perspective of this exciting and growing research area. We compiled 19 papers from some of the most prominent scientists in the carotenoid field, including seven literature reviews and 12 original publication, covering topics such as cancer, obesity, vision, cognitive function, and skin health.

membrane transporters --- RAR --- browning --- astaxanthin --- Vitamin A --- case-control study --- ?-carotene --- transcriptomic analysis --- new-born --- carotenes --- cancer-related cognitive impairment --- androgen --- beta-carotene --- eicosapentanoic acid --- mango by-products --- mangiferin --- cell culture --- chronic disease --- Akkermansia --- animal --- intestine --- carotenoids --- alcoholic fatty liver disease --- Phaeodactylum tricornutum --- carotenoid --- tomato --- colourless carotenoids --- preterm mothers --- inflammation --- ?-Cryptoxanthin --- adipocytes --- vitamin A --- gastric cancer --- food ingredients --- brain --- gut microbiota --- zeaxanthin --- nutricosmetics --- brown adipose tissue --- bioactive compounds --- breastfeeding --- aging --- oxidative stress --- retinoids --- phytofluene --- glaucoma --- H. pylori --- retinoid --- tomato extract --- retinol --- ?-cryptoxanthin --- microalgae --- fucoxanthin --- obesity --- macular pigment --- carotene --- photoprotection --- adipose tissue --- lutein --- metabolic syndrome --- Caenorhabditis elegans --- functional foods --- beta-cryptoxanthin --- retinoic acid --- nutrition --- lycopene --- bioavailability --- nutraceuticals --- adipocyte --- ?-tocopherol --- phytoene --- memory --- cosmeceuticals --- antioxidants --- mature milk --- RXR --- fat reduction --- xanthophylls --- colostrum --- smoking --- overweight --- provitamin A --- public health --- Korea --- ?-carotene oxygenase 1 --- cognition --- full-term mothers --- hippocampus --- alpha-carotene --- prostate cancer --- hypertension

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The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation