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This book offers an essential introduction to the latest advances in delayed genetic regulatory networks (GRNs) and presents cutting-edge work on the analysis and design of delayed GRNs in which the system parameters are subject to uncertain, stochastic and/or parameter-varying changes. Specifically, the types examined include delayed switching GRNs, delayed stochastic GRNs, delayed reaction–diffusion GRNs, delayed discrete-time GRNs, etc. In addition, the solvability of stability analysis, control and estimation problems involving delayed GRNs are addressed in terms of linear matrix inequality or M-matrix tests. The book offers a comprehensive reference guide for researchers and practitioners working in system sciences and applied mathematics, and a valuable source of information for senior undergraduates and graduates in these areas. Further, it addresses a gap in the literature by providing a unified and concise framework for the analysis and design of delayed GRNs.

Gene regulatory networks. --- Circuits, Gene --- Gene circuits --- Gene modules --- Gene networks --- Genetic regulatory networks --- GRNs (Gene regulatory networks) --- Modules, Gene --- Networks, Gene regulatory --- Networks, Transcriptional --- Regulatory networks, Gene --- Transcriptional networks --- Genetic regulation --- Nucleotide sequence --- Vibration. --- Engineering. --- Vibration, Dynamical Systems, Control. --- Computational Intelligence. --- Construction --- Industrial arts --- Technology --- Cycles --- Mechanics --- Sound --- Dynamical systems. --- Dynamics. --- Computational intelligence. --- Dynamical systems --- Kinetics --- Mathematics --- Mechanics, Analytic --- Force and energy --- Physics --- Statics --- Intelligence, Computational --- Artificial intelligence --- Soft computing

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Gene regulatory networks play a vital role in organismal development and function by controlling gene expression. With the availability of complete genome sequences, several novel experimental and computational approaches have recently been developed which promise to significantly enhance our ability to comprehensively characterize these regulatory networks by enabling the identification of respectively their genomic or regulatory state components, or the interactions between these two in unprecedented detail. Divided into five convenient sections, Gene Regulatory Networks: Methods and Protocols details how each of these approaches contributes to a more thorough understanding of the composition and function of gene regulatory networks, while providing a comprehensive protocol on how to implement them in the laboratory. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Gene Regulatory Networks: Methods and Protocols aims to provide novices and experienced researchers alike with a comprehensive and timely toolkit to study gene regulatory networks from the point of data generation to processing, visualization, and modeling.

Gene expression --- Genetic regulation --- Genetic regulation. --- Genregulation. --- Methode. --- Netzwerk. --- Gene Regulatory Networks --- Gene Expression Regulation --- Gene Expression --- Transcription Factors --- Simulation methods. --- Genetic Processes --- Regulatory Sequences, Nucleic Acid --- Publication Formats --- Proteins --- Publication Characteristics --- Genetic Phenomena --- Base Sequence --- Amino Acids, Peptides, and Proteins --- Genetic Structures --- Phenomena and Processes --- Chemicals and Drugs --- Laboratory Manuals --- Biology --- Health & Biological Sciences --- Biophysics --- Genetics --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Gene Module --- Gene Circuits --- Gene Modules --- Gene Networks --- Transcriptional Networks --- Circuit, Gene --- Circuits, Gene --- Gene Circuit --- Gene Network --- Gene Regulatory Network --- Module, Gene --- Modules, Gene --- Network, Gene --- Network, Gene Regulatory --- Network, Transcriptional --- Networks, Gene --- Networks, Gene Regulatory --- Networks, Transcriptional --- Regulatory Network, Gene --- Regulatory Networks, Gene --- Transcriptional Network --- Genetic Structure --- Structure, Genetic --- Structures, Genetic --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Region, Regulatory --- Regions, Regulatory --- Regulator Regions, Nucleic Acid --- Regulatory Region --- Regulatory Regions --- Nucleic Acid Regulatory Sequences --- Regulatory Regions, Nucleic Acid (Genetics) --- Genes --- Gene expression regulation --- Gene regulation --- Expression --- Regulation --- Medicine. --- Human genetics. --- Gene expression. --- Biomedicine. --- Human Genetics. --- Gene Expression. --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians

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Biotechnology --- Gene regulatory networks --- Genomics --- Research --- Systems biology --- Genómica --- Gene Regulatory Networks --- Research Support as Topic --- Systems Biology --- Systems Theory --- Government policy --- Investigación --- Genomics. --- Human Genome Project --- Genome --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Science --- Science research --- Scientific research --- Information services --- Learning and scholarship --- Methodology --- Research teams --- Genome research --- Genomes --- Molecular genetics --- Circuits, Gene --- Gene circuits --- Gene modules --- Gene networks --- Genetic regulatory networks --- GRNs (Gene regulatory networks) --- Modules, Gene --- Networks, Gene regulatory --- Networks, Transcriptional --- Regulatory networks, Gene --- Transcriptional networks --- Genetic regulation --- Nucleotide sequence --- Chemical engineering --- Genetic engineering --- Seventh Framework Programme (European Commission) --- Sixth Framework Programme (European Commission) --- European Commission. --- EU's Framework Programme for Research and Technological Development --- European Community Framework Programme for Research, Technological Development, and Demonstration --- FP6 --- Sixth FP (European Commission) --- 6. RP --- Sechstes Rahmensprogramm (European Commission) --- Sexto Programa Marco (European Commission) --- 6e programme-cadre (European Commission) --- Sixième programme-cadre (European Commission) --- Sesto programma quadro (European Commission) --- Sixth Framework Programme for Research & Technological Development --- Sixth Framework Research Programme (European Commission) --- Sjette rammeprogram for forskning (European Commission) --- Sjette rammeprogrammet (European Commission) --- Zesde kaderprogramma voor onderzoek van de EU --- Zesde kaderprogramma (European Commission) --- Kuudes tutkimuksen puiteohjelma (European Commission) --- Kuudes puiteohjelma (European Commission) --- 6o Programa-Quadro de Investigação da UE --- Sexto Programa-Quadro de Investigação da UE --- Sexto Programma Quadro (European Commission) --- Sjätte ramprogram för forskning (European Commission) --- Sjätte ramprogrammet (European Commission) --- Seventh Framework Programme for Research and Technological Development --- Framework 7 (European Commission) --- Framework Seven (European Commission) --- FP7 --- Seventh Research Framework Programme (European Commission) --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative