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This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.* Edited by two of the most highly re

Bacterial toxins. --- Bacterial antigens --- Microbial toxins

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Medical microbiology, virology, parasitology --- Bacterial toxins --- Bacterial antigens --- Microbial toxins --- Bacterial toxins.

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Cyanobacteria, or blue-green algae, commonly occur in a variety of water types throughout the world. A variable, but, high proportion of the cyanobacterial blooms and scums, which can develop annually in lakes, reservoirs, canals and slow-flowing rivers, contain potent toxins. Although animal poisonings and human health problems associated with the ingestion of, or contact with, cyanobacterial scums have long been recognized, a developing understanding of the health hazards posed by the toxins requires that reliable, sensitive, specific and convenient methods are available for their detection

Bacterial toxins --- Cyanobacteria --- Analysis --- Bacteria, Blue-green --- Blue-green algae --- Blue-green bacteria --- Blue-greens (Microorganisms) --- Cryptophyceae --- Cyanochloronta --- Cyanophyceae --- Cyanophycota --- Cyanophyta --- Myxophyceae --- Myxophyta --- Phycochromophyceae --- Schizophyceae --- Prokaryotes --- Bacterial antigens --- Microbial toxins

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Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants.  Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity.  A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants.Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.

Medicine. --- Medical microbiology. --- Infectious diseases. --- Bacteriology. --- Medicine & Public Health. --- Infectious Diseases. --- Medical Microbiology. --- Bacteria. --- Bacterial toxins. --- Bacterial antigens --- Microbial toxins --- Germs --- Microbes --- Prokaryotes --- Emerging infectious diseases. --- Microbiology. --- Microbiology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms

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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Medicine. --- Medical microbiology. --- Pharmacology. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Infectious Diseases. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Bacterial toxins. --- Bacterial antigens --- Microbial toxins --- Microbiology. --- Toxicology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Toxicology