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Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.

Antisense nucleic acids --- Antisense Elements (Genetics) --- Therapeutic use. --- pharmacology. --- therapeutic use. --- Pharmacology. --- Therapeutic use --- Molecular biology. --- Cancer research. --- Human physiology. --- Oncology  . --- Pharmacology/Toxicology. --- Molecular Medicine. --- Cancer Research. --- Human Physiology. --- Oncology. --- Tumors --- Human biology --- Medical sciences --- Physiology --- Human body --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Antisense nucleotides --- Nucleic acids

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Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs. Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.

Antisense nucleic acids --- Oligonucleotides, Antisense --- Therapeutic use --- therapeutic use --- pharmacology --- Therapeutic use. --- therapeutic use. --- pharmacology. --- Antisense nucleic acids -- Physiological effect. --- Antisense nucleic acids -- Therapeutic use. --- Electronic books. -- local. --- Antisense Elements (Genetics) --- Oligonucleotides --- Biological Science Disciplines --- Polynucleotides --- Natural Science Disciplines --- Nucleic Acids, Nucleotides, and Nucleosides --- Nucleic Acid Probes --- Nucleic Acids --- Disciplines and Occupations --- Chemicals and Drugs --- Molecular Probes --- Nucleotides --- Laboratory Chemicals --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Pharmacology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Pharmacology. --- Physiological effect. --- Antisense nucleotides --- Nucleic acids --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells