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Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors

Gene therapy. --- Adenoviruses. --- Adenoviridae --- DNA viruses --- Therapy, Gene --- Genetic engineering --- Therapeutics

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Gene therapy. --- Adenoviruses. --- Genetic vectors --- Therapeutic use. --- Cloning vectors --- Expression vectors (Genetics) --- rDNA vectors --- Recombinant DNA vectors --- Vectors, Genetic --- Gene expression --- Molecular cloning --- Recombinant DNA --- Adenoviridae --- DNA viruses --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Genetic Therapy --- methods.

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The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without.

Gene therapy. --- Human genetics. --- Gene therapy --- Human genetics --- Therapy, Gene --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Genetic engineering --- Therapeutics --- Adenoviruses. --- Genetic vectors. --- Genetic Therapy --- Adenoviridae --- Gene Transfer Techniques --- Genetic Vectors --- Thérapie génique. --- Génétique humaine. --- Adénovirus. --- Vecteurs de clonage. --- Vecteurs génétiques.

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This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Pa

Gene therapy. --- Retroviridae --- Adenoviridae --- RNA Viruses --- Oncogenic Viruses --- DNA Viruses --- Vertebrate Viruses --- Viruses --- Organisms --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Genetic Therapy. --- 575.08:577.21 --- 577.15 --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Gene --- Therapy, Somatic Gene --- Gene Therapy --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Genetic engineering, genetic manipulation, recombinant DNA --- Enzymes. Catalysts of biological reactions. Enzymology --- 577.15 Enzymes. Catalysts of biological reactions. Enzymology --- 575.08:577.21 Genetic engineering, genetic manipulation, recombinant DNA --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- DNA Virus --- Virus, DNA --- Viruses, DNA --- Tumor Viruses --- Oncogenic Virus --- Tumor Virus --- Virus, Oncogenic --- Virus, Tumor --- Viruses, Oncogenic --- Viruses, Tumor --- RNA Rodent Viruses --- RNA Rodent Virus --- RNA Virus --- Rodent Virus, RNA --- Rodent Viruses, RNA --- Virus, RNA --- Virus, RNA Rodent --- Viruses, RNA --- Viruses, RNA Rodent --- Adenoviruses --- Adenovirus --- Leukemogenic Viruses --- Leukoviruses --- Oncornaviruses --- Oncovirinae --- Oncoviruses --- Oncoviruses, Type C --- RNA Tumor Viruses --- Retroviruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- Genetic Vectors --- Microbiology --- Carcinogens --- Ichtadenovirus --- Ichtadenoviruses --- Gene Therapy. --- Adenoviruses. --- Feline immunodeficiency virus. --- Retroviruses. --- Lentiviruses. --- Viruses. --- Genetic Therapy --- Retroviridae. --- Genetic vectors --- Microorganisms --- Mobile genetic elements --- Extrachromosomal DNA --- Lentivirinae --- Lentivirus --- C-type RNA viruses --- Leukemogenic viruses --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses --- Feline T-lymphotropic lentivirus --- FIV (Virus) --- FTLV (Virus) --- Immunodeficiency virus, Feline --- Lentiviruses --- DNA viruses --- Genetic engineering --- Therapeutics --- methods. --- Genetic methods