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HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.
Anti-HIV Drugs --- HIV --- AIDS
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Pitágoras Arquitectos is an architectural firm based in Portugal with 20 years of experience. It’s growing team is now made up of 14 people, led by its four senior architectural partners, Fernando Seara de Sá, Raul Roque Figueiredo, Alexandre Coelho Lima and Manuel Vilhena Roque. In collaboration with external partners, it creates an overall multidisciplinary team that embraces every comission, local or international, large or small, to meet client expectatons and desires, always founded on strong architectural principles and ethics. An interdisciplinary practice that works all architectural fields: from interior design to urban planning, including residential, health and equipment for both the private and public sector, developing projects from concept design through to tender packages and field management.
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Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Mechanical properties of solids --- Human biochemistry --- Materials sciences --- Biomedical materials --- Biodegradation.
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The book presents a compilation of studies regarding applied geomechanics, mining, and excavation analysis and simulation. The material is suitable for presentation to senior undergraduate and post-graduate students in both mining and geological engineering. It should also be of interest to students of other aspects of Geomechanics and, notably, engineering geologists interested in mining and underground excavation design. Practising mining engineers and rock mechanics engineers involved in mine design may use the book profitably to obtain an appreciation of the current state of engineering knowledge in their area of specialisation. Papers were selected from the 5th GeoChina International Conference on Civil Infrastructures Confronting Severe Weathers and Climate Changes: From Failure to Sustainability, held in July 23-25, 2018 in Hang Zhou, China.
Geotechnical engineering --- Civil engineering --- Sustainable engineering --- Environmental aspects --- Hydraulic engineering. --- Computer simulation. --- Geotechnical Engineering & Applied Earth Sciences. --- Geoengineering, Foundations, Hydraulics. --- Simulation and Modeling. --- Computer modeling --- Computer models --- Modeling, Computer --- Models, Computer --- Simulation, Computer --- Electromechanical analogies --- Mathematical models --- Simulation methods --- Model-integrated computing --- Engineering, Hydraulic --- Engineering --- Fluid mechanics --- Hydraulics --- Shore protection --- Geotechnical engineering. --- Engineering geology. --- Engineering—Geology. --- Foundations. --- Hydraulics. --- Flow of water --- Water --- Hydraulic engineering --- Jets --- Architecture --- Building --- Structural engineering --- Underground construction --- Caissons --- Earthwork --- Masonry --- Soil consolidation --- Soil mechanics --- Walls --- Geology, Economic --- Engineering, Geotechnical --- Geotechnics --- Geotechnology --- Engineering geology --- Flow --- Distribution --- Details --- Geology
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Industries --- History
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This book constitutes the refereed proceedings of the 13th Portuguese Conference on Artificial Intelligence, EPIA 2007, held in GuimarAes, Portugal, in December 2007 as eleven integrated workshops. The 58 revised full papers presented were carefully reviewed and selected from a total of 210 submissions. In accordance with the eleven constituting workshops, the papers are organized in topical sections on general artificial intelligence (GAIW 2007), AI applications for sustainable transportation systems (AIASTS 2007), artificial life and evolutionary algorithms (ALEA 2007), ambient intelligence technologies and applications (AMITA 2007), building and applying ontologies for the semantic Web (BAOSW 2007), business intelligence (BI 2007), computational methods in bioinformatics and systems biology (CMBSB 2007), intelligent robotics (IROBOT 2007), multi-agent systems: theory and applications (MASTA 2007), search techniques for constraint satisfaction (STCS 2007), and text mining and applications (TEMA 2007).
Artificial intelligence --- Intelligence artificielle --- Congresses. --- Congrès --- Computer Science --- Mechanical Engineering - General --- Engineering & Applied Sciences --- Mechanical Engineering --- Information Technology --- Artificial Intelligence --- Computer science. --- Computer programming. --- Computers. --- Database management. --- Data mining. --- Information storage and retrieval. --- Artificial intelligence. --- Computer Science. --- Artificial Intelligence (incl. Robotics). --- Computation by Abstract Devices. --- Database Management. --- Information Storage and Retrieval. --- Data Mining and Knowledge Discovery. --- Programming Techniques. --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Calculators --- Cyberspace --- Computers --- Electronic computer programming --- Electronic digital computers --- Programming (Electronic computers) --- Coding theory --- Informatics --- Science --- Programming --- Information storage and retrieva. --- Artificial Intelligence. --- Information storage and retrieval systems.
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A folclorização é um fenómeno cultural da modernidade. Operando com as noções de folclorismo e de folclorização, a presente obra pretende equacionar os parâmetros de um processo que conduziu à mobilização e integração das populações rurais na nação. Este efeito integrador estender-se-ia também à diáspora lusa. Uma perspectiva múltipla presidiu à organização do volume: abordar o folclore como cultura expressiva, avaliar o seu papel na sociedade e apresentar elementos para facultar uma visão comparada. Os capítulos tratam os seguintes tópicos: políticas da cultura, eventos, constituição de patrimónios, associativismo, representação da tradição, protagonistas, artefactualidade, lugares, turismo e diáspora. A amplitude das abordagens adoptadas nos artigos resulta da filiação disciplinar variada dos seus autores: antropologia, etnomusicologia, história, musicologia histórica, perfomance studies e sociologia.
Folklore --- Portugal --- Portuguese-speaking countries --- Social life and customs. --- Folk beliefs --- Folk-lore --- Traditions --- Ethnology --- Manners and customs --- Material culture --- Mythology --- Oral tradition --- Storytelling --- Countries, Portuguese-speaking --- Lusophone countries --- ethnographie portugaise --- folklore --- migrations --- ethnographie --- tradition culturelle
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