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Book
Implementing Pediatric Integrative Medicine in Practice
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ISBN: 3038977632 3038977624 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue provides an overview of pediatric integrative medicine, an emerging field that blends conventional and evidence based complementary therapies with an emphasis on preventive health and wellbeing.


Book
Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Lysosomal storage disorders are a heterogenoeus group of rare genetic conditions affecting worldwide population and often exhibiting severe clinical manifestations. During the last two decades, the joined collaboration between scientists and clinicians has allowed to offer valuable therapeutic options to affected patients. Therefore, the tight connection between basic science and clinical medicine represents the gold standard approach to these disorders. In this context, the present book collects a piece of current scientific advances in the knowledge of disease pathogenesis and in the development of novel diagnostic and therapeutic strategies for some of these diseases. Altogether, these articles define and recapitulate which essential steps are required during the clinical management of a rare inherited disorder and describe forthcoming advances and a breakthrough in the field of lysosomal diseases.

Keywords

mucopolysaccharidosis IIIB --- quantitative proteomics --- NAGLU --- lysosomes --- Gaucher disease --- bone involvement --- enzyme replacement therapy --- substrate reduction therapy --- Osteoimmunology --- RANK/RANKL --- Osteopontin --- MIP-1β --- mucolipidosis II --- sortilin --- TGF-beta --- cathepsin D --- Fabry disease --- alpha-galactosidase A --- endocytosis --- lysosome --- IGF2R/M6P --- clathrin --- chloroquine --- lysosomal diseases --- precision medicine --- pharmacological chaperones --- gene therapy. --- Pompe disease --- lysosomal targeting --- autophagy --- gene therapy --- muscle --- satellite cells --- rhGAA --- glycogen --- lysosomal α-glucosidase --- GAA biomarker --- Gaucher Disease --- Wnt/β-catenin --- Dkk1 --- Wnt3a --- iPSC --- neuronopathy --- Krabbe disease --- Twitcher mouse --- psychosine --- visual system --- visual cortex --- astrogliosis --- mucopolysaccharidosis type I --- Hurler syndrome --- hematopoietic stem cell transplantations --- animal models --- experimental therapies --- axon guidance --- lysosomal storage disorders --- neuronal circuit --- α-galactosidase A --- A4GALT --- globotriaosylceramide (Gb3) --- globotriaosyl-sphingosine (lysoGb3) --- pharmacological chaperone therapy --- exosomes --- endocytic pathways --- neurodegenerative disease --- Parkinson disease --- lysosomal storage disorder --- viral vectors --- newborn screening --- variant interpretation --- second tier test --- tandem mass spectrometry --- lyso-Gb3 --- dried blood spot --- GLA gene --- globotriaosylsphingosine --- biomarkers


Book
Head and Neck Critical Illness : Basic and Clinical Research Implications
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

There are various malignant tumors in the head and neck area, including oral cavity, pharynx, sinonasal cavity, and salivary glands. Squamous cell carcinoma is the most common cancer among head and neck cancers. In salivary glands, there are many types of malignancies that can develop, such as malignant lymphoma, adenoid cystic carcinoma, adenocarcinoma, and mesenchymal tumors. In a clinical setting, imaging, such as computed tomography (CT) and magnetic resonance imaging (MRI), is very important in terms of the prediction of the histological type and the evaluation of the extent of invasion of adjacent structures. In basic research, there are few animal models in head and neck malignancies. In this Special Issue, we broadly discuss the basic and clinical research in head and neck malignancies.

Keywords

BDNF --- Brain-Derived Neurotrophic Factor --- navigation --- spatial processing --- trauma --- trauma processing --- Post-Traumatic Stress Disorder --- PSTD --- allocentric --- hippocampus --- sinonasal tract --- malignant tumor --- CT --- MRI --- neuropsychiatric presentation of encephalitis --- paraneoplastic encephalitis --- autoimmune encephalitis --- infectious encephalitis --- diffuse large B-cell lymphoma --- canaloplasty --- non-perforating surgical procedures --- corticosteroid-induced glaucoma --- Schlemm’s canal --- neck mass --- diffusion-weighted MRI --- apparent diffusion coefficient --- procalcitonin --- bacterial meningitis --- viral meningitis --- antibiotic therapy --- biomarker --- differential diagnosis --- human papillomavirus --- human cancer --- head and neck --- reduction therapy --- head and neck squamous cell carcinoma (HNSCC) --- neutrophil-to-lymphocyte ratio (NLR) --- myeloid-derived suppressor cells (MDSC) --- aldehyde dehydrogenase 1 (ALDH1) --- prognosis --- prodigiosin --- doxorubicin --- priming --- influx --- autophagy --- cervical --- cellulitis --- abscess --- deep neck infection --- diabetes mellitus --- MAP1LC3B --- SQSTM1 --- subsites --- tumorigenesis --- oral cancer --- Nox4 --- oral tongue cancer --- squamous cell carcinoma --- surgery --- head and neck squamous cell carcinoma --- HPV --- 11q13 --- gene amplification --- immunohistochemistry --- head and neck cancer --- radiotherapy --- neutrophil/lymphocyte ratio --- survival --- ZFAND4 --- ANUBL1 --- oral squamous cell carcinoma --- nucleotide excision repair --- genetic polymorphism --- concurrent chemoradiotherapy --- HNSCC --- MIF --- 4-IPP --- metabolism --- annexin A9 --- annexin A10 --- differentiation grade --- NGS

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