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Pain management in animals
Authors: ---
ISBN: 0702017671 9780702039287 0702039284 9780702017674 9780702017674 Year: 2000 Publisher: [Place of publication not identified] W B Saunders

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Keywords

Animal husbandry --- Anesthesia and Analgesia --- Sensory System Agents --- Neurologic Manifestations --- Sensation --- Central Nervous System Agents --- Signs and Symptoms --- Nervous System Physiological Processes --- Peripheral Nervous System Agents --- Psychophysiology --- Pathological Conditions, Signs and Symptoms --- Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutic Uses --- Physiological Effects of Drugs --- Diseases --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Pharmacologic Actions --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Actions and Uses --- Psychiatry and Psychology --- Phenomena and Processes --- Chemicals and Drugs --- Analgesics --- Analgesia --- Pain --- Health & Biological Sciences --- Veterinary Medicine --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Pain Insensitivity, Congenital --- Hyperalgesia --- Palliative Care --- Analgesias --- Analgesic Agents --- Analgesic Drugs --- Analgesic --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Agents, Antinociceptive --- Drugs, Analgesic --- Anesthetics --- Peripheral Nervous System Drugs --- Peripheral Nervous System Effect --- Peripheral Nervous System Effects --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Drug Effects on Physiology --- Drug Physiological Effects --- Effects, Drug Physiological --- Physiological Effects, Drug --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Symptoms and General Pathology --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Symptoms and Signs --- Central Nervous System Drugs --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Sensory System Drugs --- Agents, Sensory System --- Drugs, Sensory System --- System Agents, Sensory --- System Drugs, Sensory --- Analgesia and Anesthesia --- physiology --- PAIN --- PAIN MEASUREMENT --- PAIN, POSTOPERATIVE --- VETERINARY --- DRUG THERAPY --- Nervous System Physiological Phenomena. --- Disease.


Book
The State of the Art in Endodontics
Authors: --- ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Nowadays, we use the term “modern endodontics” thanks to new technologies, novel materials, and revolutionary techniques. Various equipment is available to facilitate and improve our endodontic treatments, such as operating microscopes, ultrasounds, lasers, modern alloys for rotary files, powerful irrigation systems, new materials for filling root canals, 3D radiology, and several more. With the aid of the previously mentioned advances, complex endodontic treatments can be carried out safely, hence guaranteeing patients a high level of care and, above all, saving teeth that would otherwise be doomed for extraction. General practitioners and, even more importantly, specialists in endodontics should implement these modern technologies in their practice. This Special Issue will focus on modern endodontics regarding all the recent updates. Full papers of original articles, short communications, and review articles are all invited.

Keywords

meta-analysis --- root canal filling --- postoperative pain --- bioceramic sealer --- analgesic intake --- flare-up --- endodontics --- cyclic fatigue --- cross-section design --- NiTi --- continuous rotation --- energy-dispersive X-ray --- apical plug --- BioRoot RCS --- micro-computed tomography --- MTA Flow --- porosity --- root perforation --- single cone --- ultrasonic --- endodontic rotary files --- finite element analysis --- fatigue analysis --- pediatric dentistry --- oral health --- dental medicine --- systematic review --- umbrella review --- endodontic reciprocating file --- micro-computed tomography scan --- root canal dentin removal --- primary molar teeth --- pulpotomy --- pulpitis --- toothache --- treatment outcome --- tricalcium silicate --- accuracy --- computed-assisted template --- computer-aided static navigation --- cone-beam computed tomography scan --- digital impression --- tooth autotransplantation --- endodontic surgery --- periapical lesion --- guided tissue regeneration --- bone graft --- membrane --- platelet rich fibrin --- nanodroplets --- confocal laser microscope --- benzalkonium chloride --- chlorhexidine --- sodium hypochlorite --- viability staining --- dental anatomy --- dental pulp --- dental diagnostic imaging --- morphology --- Micro-CT --- root --- root canal --- n/a --- endodontic file --- cross-section --- pitch --- flexural bending --- torsion --- stress distribution --- endodontic rotary file --- reciprocating --- speed --- resistance --- apexification --- endodontic therapy --- immature permanent tooth --- pulp --- regeneration


Book
Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
Authors: ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.


Book
Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care
Authors: --- ---
ISBN: 9781461489481 1461489474 9781461489474 1461489482 Year: 2015 Publisher: New York, NY : Springer New York : Imprint: Springer,

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In anesthesiology, pain medicine, and critical care, practitioners at all levels need help to stay current with the continually evolving drug knowledge-base, and trainees need tools to prepare for in-training and board exams that increasingly test their knowledge of pharmacology. This practical book is aimed at both readerships. It features a unique and practical chapter on the United States Food and Drug Administration (FDA) “black box” warnings that describe what safety precautions should be taken with commonly used drugs. The editors and contributors are pharmacology experts representing a cross-section of clinical specialties and institutions in the United States and include pharmacologists, pharmacists, as well as physicians.

Keywords

Medicine & Public Health. --- Anesthesiology. --- Pain Medicine. --- Intensive / Critical Care Medicine. --- Medicine. --- Critical care medicine. --- Médecine --- Anesthésiologie --- Soins intensifs --- Pharmacology --- Anesthesiology --- Anesthesia adjuvants --- Critical care medicine --- Pain medicine --- Patient Care --- Central Nervous System Depressants --- Central Nervous System Agents --- Health Occupations --- Neurologic Manifestations --- Therapeutics --- Biological Science Disciplines --- Signs and Symptoms --- Sensation --- Sensory System Agents --- Nervous System Diseases --- Health Services --- Therapeutic Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Physiological Effects of Drugs --- Nervous System Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Psychophysiology --- Peripheral Nervous System Agents --- Pharmacologic Actions --- Diseases --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Health Care Facilities, Manpower, and Services --- Chemical Actions and Uses --- Psychiatry and Psychology --- Health Care --- Musculoskeletal and Neural Physiological Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Pain --- Analgesics --- Anesthetics --- Critical Care --- Drug Therapy --- Surgery & Anesthesiology --- Health & Biological Sciences --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Surgical Intensive Care --- Intensive Care --- Intensive Care, Surgical --- Care, Critical --- Care, Intensive --- Care, Surgical Intensive --- Anesthetic Agents --- Anesthetic Drugs --- Anesthetic Effect --- Anesthetic Effects --- Agents, Anesthetic --- Drugs, Anesthetic --- Effect, Anesthetic --- Effects, Anesthetic --- Analgesic Agents --- Analgesic Drugs --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Pharmacologies --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Healthcare Facilities, Manpower, and Services --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Psychologic Processes and Principles --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Symptoms and General Pathology --- Drug Effects on Physiology --- Drug Physiological Effects --- Effects, Drug Physiological --- Physiological Effects, Drug --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Services, Health --- Health Service --- Service, Health --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Symptoms and Signs --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Health Professions --- Health Occupation --- Health Profession --- Occupation, Health --- Occupations, Health --- Profession, Health --- Professions, Health --- Central Nervous System Drugs --- Informal care --- Care, Patient --- Informal cares --- care, Informal --- cares, Informal --- Intensive care --- Intensive medicine --- Adjuvants, Anesthesia --- Anaesthesiology --- Drug effects --- Medical pharmacology --- drug therapy --- therapeutic use --- pharmacology --- physiology --- therapy --- Sensory System Drugs --- Agents, Sensory System --- Drugs, Sensory System --- System Agents, Sensory --- System Drugs, Sensory --- Peripheral Nervous System Drugs --- Peripheral Nervous System Effect --- Peripheral Nervous System Effects --- CNS Depressants --- Depressants, CNS --- Pain medicine. --- Medicine --- Emergency medicine --- Intensive care units --- Surgery --- Algiatry


Book
Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Keywords

opioid receptors --- neurokinin-1 receptor --- peptide synthesis --- receptor binding studies --- functional assay --- writhing test --- tolerance --- Leu-enkephalin --- beta-arrestin --- mu opioid receptor --- delta opioid receptor --- biased signaling --- DADLE --- ischemia --- plasma stability --- morphinan --- BNTX --- δ opioid receptor antagonist --- 1H-NMR experiments --- mechanism elucidation --- peripheral antinociception --- 14-methoxycodeine-6-O-sulfate --- codeine-6-O-sulfate --- opioid peptides and peptidomimetics --- DAMGO --- DALDA --- [Dmt1]DALDA --- KGOP01 --- binding --- molecular docking --- structure-activity relationships --- β2-amino acids --- β2-Homo-amino acids --- µ-opioid receptor --- opioid peptides --- TAPP --- racemic synthesis of β2-amino acids --- peripheral µ-opioid receptors --- analgesia --- peripheral analgesic tolerance --- dysbiosis --- opioid --- bifunctional ligands --- (−)-N-phenethylnorhydromorphone analogs --- [35S]GTPgammaS assay --- forskolin-induced cAMP accumulation assays --- β-arrestin recruitment assays --- MOR and DOR agonists --- respiratory depression --- bias factor --- molecular modeling &amp --- simulation --- δ opioid receptor --- NTI derivative --- sulfonamide --- inverse agonist --- neutral antagonist --- agonist --- opioids --- mu receptor --- opioid side effects --- biased agonism --- partial agonism --- zerumbone --- chronic constriction injury (CCI) --- allodynia --- hyperalgesia --- potassium channels --- over-the-counter drugs --- misuse --- abuse --- opioid drugs --- pharmacology --- codeine --- dihydrocodeine --- loperamide --- opioid peptide --- macrocyclic tetrapeptide --- multifunctional ligands --- kappa opioid receptor --- analgesics --- opioid liabilities --- μ opioid receptor --- receptor model --- biased ligands --- dependence --- pain therapy --- neonatal opioid withdrawal syndrome --- naltrexone --- 6β-naltrexol --- buprenorphine --- G-protein bias --- arrestin recruitment --- respiration --- mitragynine --- heteromer --- internalization --- primary hippocampal culture --- lysosomes --- µ opioid receptor --- molecular dynamics --- docking --- interaction fingerprints --- biased agonists --- SR-17018 --- PZM21 --- morphine --- fentanyl --- diphenethylamines --- design and synthesis --- structure–activity relationships --- partial agonist --- biased agonist --- antagonist --- binding affinity --- selectivity --- n/a


Book
Cellular Oxidative Stress
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This book collects 17 original research papers and 9 reviews that are part of the Special Issue “Cellular Oxidative Stress”, published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.

Keywords

neuroinflammation --- clinical --- palmitoylethanolamide --- luteolin --- co-ultramicronization --- CNS pathology --- adaptive immune response --- cell homeostasis --- legumes --- liver --- hepatic steatosis --- lipid dyshomeostasis --- ROS --- traumatic brain injury --- palmitoylethanolamide (PEA) --- therapeutic strategies --- oxidative stress. --- RNA-Seq --- RPE --- Retinitis pigmentosa --- A2E --- diabetes --- glucose exposure --- oxidative stress --- Band 3 protein --- erythrocytes --- SO42− --- 4-hydroxy-2-nonenal --- 3-glutathionyl-4-hydroxynonanal --- astrocytoma cells --- soy --- soybeans --- soy foods --- antioxidants --- reactive oxygen species --- cardiovascular diseases --- cancer --- paw edema --- cashew nuts --- antioxidant --- inflammation --- polyphenols --- analgesic --- d-Galactose --- glycation --- SO42− uptake --- anion exchange --- diseases --- immune system --- NF-κB --- cigarette smoke extract --- nasal fibroblasts --- tissue inhibitor of metalloproteinases --- matrix metalloproteinase --- steroids --- Plasmodium falciparum --- syk kinase inhibitors --- artemisinin derivatives --- hemichromes --- cellular redox state --- mitochondrial function --- cisplatin nephrotoxicity --- acute pancreatitis --- obesity --- nitrosative stress --- PGC-1α --- microparticles --- vesiculation --- band 3 --- tert-Bytyl hydroperoxide t-BOOH --- nitric oxide donor --- calcium ionophore A23187 --- age-related macular degeneration (AMD) --- diet --- Substance-P --- adipose-derived stem cells --- paracrine factors --- epilepsy --- status epilepticus --- Trolox --- HeLa --- prooxidant --- AVD --- apoptosis --- neurodegeneration --- ncRNA --- miRNA --- tRNA fragments --- lncRNA --- circRNA --- preeclampsia --- hemostasis --- platelets --- coagulation --- fish --- mucosal immunity --- nasal immunity --- peroxide --- vitamin C --- NAC --- immunosenescence --- T cells --- vaccination --- aging --- microvascular permeability --- bradykinin --- interleukin 1β --- NADPH oxidase --- simvastatin --- molecular hydrogen --- autophagy --- matrix metalloproteinases --- reactive oxygen species (ROS) --- phytochemicals --- dietary chemicals --- natural compounds --- programmed cell death --- anoikis --- ferroptosis --- pyroptosis --- n/a


Book
Celebrating 120 Years of Butantan Institute Contributions for Toxinology
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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This is collection of original and review articles selected in recognition of the contribution of Instituto Butantan to the field of toxinology and its continued and relevant role in this field in the 120 years since its foundation. Congratulations to the Butantan Institute, its house scientists, and collaborators on its 120th anniversary!

Keywords

mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial–mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins --- n/a --- epithelial-mesenchymal transition


Book
Structural and Functional Analysis of Extracts in Plants
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Structural and Functional Analysis of Extracts in Plants collects 1 editorial, 3 reviews, and 26 research articles reporting recent research findings which cover several aspects of plant-derived bioactive compounds, to correlate extraction techniques with the chemical composition of extracts and their bioactivity for identifying molecules that might be used as active substances in a wide variety of areas.This book is a valuable resource for members of the scientific community wishing to further explore plants and the therapeutic applications of their bioactive compounds. It will appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Keywords

hierarchical cluster analysis --- principal component analysis --- ultrasound-assisted extraction --- triterpenic acid --- Ziziphus jujuba --- water-pepper --- FRAP --- DPPH --- polarity-based solvent extraction --- α-amylase inhibition --- circular economy --- green biorefinery --- polyunsaturated fatty acids --- phytochemicals --- amino acids --- food and feed --- UHPLC-ESI-ORBITRAP-MS/MS --- Bergenia emeiensis --- polysaccharides --- optimization --- RSM --- acrylamide-induced damage --- Sorbus commixta fruit --- anti-melanoma activity --- caspase-3 --- polyphenolic compounds --- depression --- antioxidant --- cytokines --- anti-inflammatory --- cytotoxicity --- medicinal mushroom --- Psilocybe natalensis --- coak oak --- chlorophyll --- terpenes --- lupeol --- cuticular permeance --- Suaeda vermiculata --- halophyte --- aqueous-ethanolic extract --- liver toxicity --- hepatoprotective --- liver disorders --- mass spectrometry --- LC-MS --- HepG-2 --- HepG-2/ADR --- zebrafish --- toxicity --- embryotoxicity --- medicinal plant --- animal model --- Crocus sativus --- in vivo --- carrageenan --- analgesic --- antidepressant --- anticoagulant --- adipogenesis --- AMPK --- anti-obesity --- triglycerides --- UCP1 --- Anacardiaceae --- design of experiments (DOEs) --- flavonoids --- green extraction --- HPLC-DAD --- LC-MS/MS --- tannins --- ultrasound assisted-extraction (UAE) --- compact mass spectrometry --- cleansing properties --- detergent plants --- phytochemical --- tissue culture --- Arbutus pavarii --- antibacterial activity --- MRSA --- time–kill curves --- ultrahigh-performance liquid chromatography --- mass spectrometry (UHPLC- ESI-MS/MS) --- Trigonella stellata --- caffeic acid --- osteoporosis --- osteoblast --- osteoclast --- BMP --- Euphorbia cuneata --- Euphorbiaceae --- lipopolysaccharide --- oxidative stress --- NF-κB --- lung injury --- pachycereus weberi --- escontria chiotilla --- antioxidant activity --- phenolic compounds --- betalains --- food composition --- food analysis --- Scrophularia buergeriana --- S. koraiensis --- S. takesimensis --- harpagoside --- osteoclast differentiation --- RANKL --- Araucaria angustifolia --- bioactive compounds --- cysteine protease inhibitor --- functional food --- insecticide --- plant extracts --- termites --- tumor cells --- pine nuts --- urban pest --- polyphenols --- fruit development --- natural food colorant --- Sambucus canadensis --- Japanese knotweed --- Reynoutria --- Polygonum --- Polygonaceae --- anthraquinones --- emodin --- physcion --- HPTLC --- HPTLC-MS --- densitometry --- carrot juices --- carotenoids --- high-speed juicer --- low-speed juicer --- food processing --- extraction --- glucosinolates --- kale (Brassica oleracea var. acephala) --- phenolics --- candelilla plant --- antioxidant properties --- antimicrobial activity --- candelilla cultivation --- candelilla wax --- polysterols --- saponins --- therapeutic properties --- sage --- stirring and heating extraction --- mechanochemical extraction --- antiproliferative activity --- mutagenicity --- anticoagulant activity --- Rosmarinus officinalis --- hydroalcoholic extract --- Sam-Myo-Whan --- traditional medicine --- gouty arthritis --- inflammation --- monosodium urate --- Underutilized Mexican plants --- Cactus fruits --- Antioxidant activities --- Antiproliferative properties --- n/a --- time-kill curves

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