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This book focuses on the recent advancements in both fundamental and clinical research, focusing on identifying, developing, and applying new and improved biological markers for specific neurologic disorders in the future. The original research work and review articles published here highlight some unique mechanisms underlying the most prevalent pathophysiological conditions affecting human health. Other areas covered in the book include emerging treatment options and correct diagnoses using different biochemical and imaging techniques.
Medicine --- Alzheimer’s disease --- amyloid beta --- hippocampus --- Kir channels --- K+ channels --- glioblastoma multiforme --- low-grade glioma --- astrocytoma --- recurrence --- multifocal growth --- mRNA expression --- MPS1 --- TTK --- therapy --- EDTA chelation therapy --- neurodegenerative diseases --- metal detoxification --- reactive oxygen species (ROS) --- neuroinflammation --- neurodegeneration --- cognitive dysfunction --- neurofibrillary tangles --- diagnosis methods --- biomarkers --- perinatal stress --- NURR1 --- inflammation --- late-onset diseases --- early life --- artificial neural network --- deep learning --- Parkinson’s disease --- atypical parkinsonian syndrome --- dopamine transporter SPECT --- β-Amyloid --- calpain --- Collapsin Response Mediator Protein-2 --- human-neuroblastoma SH-SY5Y cells --- Somatostatin-14 --- somatostatin receptor --- brain injury --- quinpirole --- dopamine D2 receptors --- glial cell --- autophagy --- mitophagy --- multiple sclerosis --- biomarker --- neurons --- astrocytes --- Alzheimer’s and Parkinson’s diseases --- fluid and imaging biomarkers --- amyloid-β and tau --- miRNA --- extracellular vesicles --- exosomes and ectosomes --- PET --- radiotracers --- radiolabeled molecules --- n/a --- Alzheimer's disease --- Parkinson's disease --- Alzheimer's and Parkinson's diseases
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Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
n/a --- liver graft injury --- HFE --- neurokinin --- chemotherapy --- intestinal tumors --- therapeutic targets --- biliary tract carcinoma --- hepatocellular carcinoma --- clinical trial --- cell adhesion molecules --- colorectal cancer --- biomarkers --- phenotypic mosaics --- gastrointestinal oncology --- Asian Cancer Research Group (ACRG) --- biomarker --- psychosocial support --- precision therapy --- pancreatic carcinoma --- precision medicine --- Liver transplantation --- predictive biomarkers --- CD274 --- cholecystokinin --- The Cancer Genome Atlas (TCGA) --- gastrin --- pembrolizumab --- immunotherapy --- gastrin-releasing peptide --- stereotactic body radiation therapy --- immunohistochemistry --- gastric carcinoma --- liver transplant --- CAM invasion assay --- intragraft gene expression profiles --- molecular profiling --- targeted therapy --- neurotensin --- intestinal disorder --- ramucirumab --- next-generation sequencing --- colorectal carcinoma --- tumor progenitor --- circulating tumor cells --- gastrointestinal malignancies --- bombesin --- trastuzumab --- somatostatin --- zebrafish --- G protein–coupled receptors --- G protein-coupled receptors
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This Special Issue is dedicated to neuroendocrine neoplasms (NENs), a category of malignancy that demonstrates wide clinical heterogeneity, posing major challenges in diagnosis and management. There have been significant advances in the field of NEN genomics, pathology, imaging, and treatment over the past five years. NENs are examples of rare tumours (although their incidence and prevalence are increasing) where international collaborative efforts have allowed the generation of high-level evidence to guide optimal patient-centred care. This issue presents both reviews and original papers to provide comprehensive state-of-the-art understanding of this fascinating disease.
small bowel neuroendocrine tumours --- pancreatic neuroendocrine tumours --- liver metastases --- midgut --- meta-analysis --- neuroendocrine tumors --- carcinoid heart disease --- carcinoid syndrome --- somatostatin analogues --- metastases --- multidisciplinary --- management --- outcome --- grading --- staging --- neuroendocrine neoplasms --- chemotherapy --- temozolomide --- metronomic treatment --- second-line --- NOTCH --- cancer-driven genes --- mutational mechanism --- germline mutations --- small cell lung carcinoma --- pancreatic NET --- small bowel NET --- medullary thyroid carcinoma --- malignant castration-resistant prostatic cells --- quality performance indicators --- QPIs --- cancer care --- neuroendocrine tumour --- NETs --- modified Delphi --- CommNETs --- pancreatic neuroendocrine neoplasms --- neuroendocrine tumor --- long-term functional outcomes --- pancreatectomy --- diabetes mellitus --- pancreatic exocrine insufficiency --- body mass index --- parenchyma-sparing surgery --- neuroendocrine tumours --- curative surgery --- resection --- follow-up --- guidelines --- relapse --- recurrence --- risk factor --- mixed non-neuroendocrine neuroendocrine neoplasms --- MiNENs --- mixed adeno-neuroendocrine carcinoma --- MANEC --- 2017 WHO classification --- 2019 WHO classification
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Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.
positron emission tomography (PET) --- pyrazoles --- fluorine-18 --- radionuclides --- PET probes --- imaging pharmaceuticals --- hypopharyngeal cancer --- 188Re-liposome --- repeated therapy --- NGS --- microRNA --- aprepitant --- radiopharmaceuticals --- neurokinin 1 receptor antagonist --- radionuclide chelators --- kidney uptake --- cleavable linkers --- neutral endopeptidase (NEP) --- renal brush border enzymes --- prostate-specific membrane antigen (PSMA) --- cancer imaging and therapy --- somatostatin analogs --- radiolabeling --- radionuclide therapy --- imaging --- adrenergic receptor --- positron emission tomography --- radiotracer --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- targeted radiotherapy --- lutetium-177 --- EpCAM --- radionuclide --- SPECT --- iodine --- PIB --- breast --- cancer --- PET --- target-specific biomolecules --- immunoPET imaging pharmaceuticals --- production processes --- 124I-labeled monoclonal antibodies --- radiotracers --- AAZTA --- scandium-44 --- FAP --- SA --- DPP --- PREP --- radioiodine labeling --- radioiodination --- biomolecules --- peptides --- proteins --- monoclonal antibodies --- 123,124,125,131I-labeled molecules and biomolecules --- n/a
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The issue of Cancers Journal entitled “Role of Medical Imaging in Cancers” presents a detailed summary of evidences about molecular imaging, including the role of computed tomography (CT), magnetic resonance imaging (MRI), single photon emission tomography (SPET) and positron emission tomography (PET) or PET/CT or PET/MR imaging in many type of tumors (i.e. sarcoma, prostate, breast and others), motivating the role of these imaging modalities in different setting of disease and showing the recent developments, in terms of radiopharmaceuticals, software and artificial intelligence in this field. The collection of articles is very useful for many specialists, because it has been conceived for a multidisciplinary point of view, in order to drive to a personalized medicine.
Medicine. --- positron emission tomography --- head and neck neoplasms --- neovascularization --- pathologic --- PET/CT --- urothelial carcinoma --- bladder cancer --- upper tract urothelial carcinoma --- survival --- PET --- PSMA --- prostate --- DCFPyL --- DCFBC --- PSMA-1007 --- ovarian cancer --- relapse --- SUVmax --- targeted therapy --- prognosis --- soft tissue sarcoma (STS) --- pazopanib --- dynamic 18F-FDG PET/CT --- SUV --- two-tissue compartment model --- magnetic resonance imaging --- machine learning --- diffusion --- perfusion --- texture analysis --- squamous cell carcinoma of the head and neck --- diffusion-weighted imaging --- malignant pleural mesothelioma --- pleural dissemination --- empyema --- pleural effusion --- mCRPC --- SPECT/CT --- Computer-assisted diagnosis --- XOFIGO --- Therapy response assessment --- circulating miRNAs --- breast cancer --- imaging parameters --- PET/MRI --- biomarkers --- triple negative breast cancer --- VCAM-1 --- SPECT imaging --- sdAbs --- Hounsfield unit --- computed tomography --- adipose tissue --- precision oncology --- FDG-PET/CT --- PERCIST --- metastatic breast cancer --- prostate cancer --- 18F-FACBC --- recurrence --- meta-analysis --- review --- meningioma --- somatostatin receptor --- neuroimaging --- radionuclide therapy --- breast --- imaging --- marker --- radiomics --- Yin Yang 1 --- PDAC --- Mesothelin --- noninvasive imaging --- receptor status --- molecular imaging --- nuclear medicine --- guidelines --- overutilization --- epistemology --- consensus --- mantle cell lymphoma --- 18F-FDG PET/CT --- Deauville criteria --- Radium-223 --- FDG --- castrate resistant prostate cancer --- programmed cell death 1 receptor --- diagnostic imaging --- CTLA-4 Antigen --- Immunotherapy --- Adoptive --- radioactive tracers --- radionuclide imaging --- CD8-Positive T-Lymphocytes --- PI-RADS --- diffusion kurtosis imaging --- dynamic contrast-enhanced magnetic resonance imaging --- 68Gallium-PSMA PET/CT --- prostate-specific-antigen --- PSA kinetics thresholds --- biochemical recurrence --- optimal cutoff level --- non-small-cell lung cancer --- circulating tumor cells --- immunotherapy --- response to treatment --- head and neck cancer --- HPV --- EBV --- p16 --- Molecular imaging --- miRNA expression --- radiogenomics --- radiomic --- diagnosis --- biomarker --- glioblastoma --- radiation therapy --- MRI --- diffusion tensor imaging --- Hodgkin lymphoma --- diffuse large B-cell lymphoma --- staging --- response assessment --- locally advanced cervical cancer --- concurrent chemoradiotherapy --- treatment response --- follow up --- cystic tumor --- International Consensus Guidelines --- intraductal papillary mucinous neoplasms --- pancreatic neoplasms --- PD-1 --- PD-L1 --- response to therapy --- NSCLC --- positron-emission tomography --- single-photon emission computed tomography --- immune checkpoint inhibitors --- gold nanoparticle --- heat shock protein 70 --- spectral-CT --- n/a
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Medicine. --- positron emission tomography --- head and neck neoplasms --- neovascularization --- pathologic --- PET/CT --- urothelial carcinoma --- bladder cancer --- upper tract urothelial carcinoma --- survival --- PET --- PSMA --- prostate --- DCFPyL --- DCFBC --- PSMA-1007 --- ovarian cancer --- relapse --- SUVmax --- targeted therapy --- prognosis --- soft tissue sarcoma (STS) --- pazopanib --- dynamic 18F-FDG PET/CT --- SUV --- two-tissue compartment model --- magnetic resonance imaging --- machine learning --- diffusion --- perfusion --- texture analysis --- squamous cell carcinoma of the head and neck --- diffusion-weighted imaging --- malignant pleural mesothelioma --- pleural dissemination --- empyema --- pleural effusion --- mCRPC --- SPECT/CT --- Computer-assisted diagnosis --- XOFIGO --- Therapy response assessment --- circulating miRNAs --- breast cancer --- imaging parameters --- PET/MRI --- biomarkers --- triple negative breast cancer --- VCAM-1 --- SPECT imaging --- sdAbs --- Hounsfield unit --- computed tomography --- adipose tissue --- precision oncology --- FDG-PET/CT --- PERCIST --- metastatic breast cancer --- prostate cancer --- 18F-FACBC --- recurrence --- meta-analysis --- review --- meningioma --- somatostatin receptor --- neuroimaging --- radionuclide therapy --- breast --- imaging --- marker --- radiomics --- Yin Yang 1 --- PDAC --- Mesothelin --- noninvasive imaging --- receptor status --- molecular imaging --- nuclear medicine --- guidelines --- overutilization --- epistemology --- consensus --- mantle cell lymphoma --- 18F-FDG PET/CT --- Deauville criteria --- Radium-223 --- FDG --- castrate resistant prostate cancer --- programmed cell death 1 receptor --- diagnostic imaging --- CTLA-4 Antigen --- Immunotherapy --- Adoptive --- radioactive tracers --- radionuclide imaging --- CD8-Positive T-Lymphocytes --- PI-RADS --- diffusion kurtosis imaging --- dynamic contrast-enhanced magnetic resonance imaging --- 68Gallium-PSMA PET/CT --- prostate-specific-antigen --- PSA kinetics thresholds --- biochemical recurrence --- optimal cutoff level --- non-small-cell lung cancer --- circulating tumor cells --- immunotherapy --- response to treatment --- head and neck cancer --- HPV --- EBV --- p16 --- Molecular imaging --- miRNA expression --- radiogenomics --- radiomic --- diagnosis --- biomarker --- glioblastoma --- radiation therapy --- MRI --- diffusion tensor imaging --- Hodgkin lymphoma --- diffuse large B-cell lymphoma --- staging --- response assessment --- locally advanced cervical cancer --- concurrent chemoradiotherapy --- treatment response --- follow up --- cystic tumor --- International Consensus Guidelines --- intraductal papillary mucinous neoplasms --- pancreatic neoplasms --- PD-1 --- PD-L1 --- response to therapy --- NSCLC --- positron-emission tomography --- single-photon emission computed tomography --- immune checkpoint inhibitors --- gold nanoparticle --- heat shock protein 70 --- spectral-CT --- n/a
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