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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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The field of periorbital surgery has expanded exponentially in recent decades. With its rise in popularity, however, comes a rise in complications. Finally there is a comprehensive guide to repairing the problems encountered in periorbital surgery, compiled by masters in the art of periorbital surgery! This unique resource for plastic, facial plastic and oculoplastic surgeons offers several key features: Stepwise guidance for correcting a range of complications in periorbital surgery, including infection and bleeding, blindness and motility disorders, specific upper and lower eyelid problems including lid retraction, chemosis, and adverse results from fillers and resurfacing; Several chapters, presenting different approaches, devoted to the challenging problem of lid retraction and its multifactorial etiology; A case-report format that provides detailed discussions of all possible complications; Expert techniques from renowned surgeons providing multiple perspectives on the same problems; Multiple video clips showing details of eyelid evaluation and corrective techniques. -- Publisher
Blepharoplasty --- Reconstructive Surgical Procedures --- Eyelids --- Rejuvenation --- Dermal Fillers --- adverse effects --- surgery
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Head --- Therapeutics --- Reconstructive Surgical Procedures --- Cosmetic Techniques --- Complementary Therapies --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Body Regions --- Surgical Procedures, Operative --- Anatomy --- Face --- Rejuvenation --- Rhytidoplasty
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Midfacial Rejuvenation is a comprehensive review of the majority of procedures and options for midfacial aesthetic and corrective surgery. Each contributor offers a unique approach to the midfacial area, with detailed specifics for every technique. Chapters on midfacial anatomy, complications and their management complete the comprehensive coverage of the subject matter, resulting in a reference text that will benefit every practitioner dealing with the midfacial region. Features: · One of the first books to focus exclusively on the midfacial area · Highly illustrated and with clear, step-by-step instructions on performing a variety of midface lifts, implants, sutures, grafts, and fillers · Over 300 full color images · Includes in-depth chapters on midfacial anatomy and the anatomic basis of aging · Multiple approaches to midfacial rejuvenation by well-known surgeons in fields such as oculoplastics, facial plastics, general plastics, and dermatologists .
Face -- Surgery. --- Facelift. --- Facial bones -- Surgery. --- Rejuvenation. --- Surgery, Plastic. --- Face --- Surgery, Plastic --- Facial bones --- Rejuvenation --- Skull --- Therapeutics --- Surgical Procedures, Operative --- Head --- Complementary Therapies --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Body Regions --- Bone and Bones --- Anatomy --- Skeleton --- Musculoskeletal System --- Reconstructive Surgical Procedures --- Cosmetic Techniques --- Methods --- Facial Bones --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Surgery - General and By Type --- Surgery --- Surgery. --- Aesthetic surgery --- Cosmetic surgery --- Plastic surgery --- Reconstructive surgery --- Surgery, Aesthetic --- Surgery, Cosmetic --- Surgery, Reconstructive --- Maxillofacial surgery --- Medicine. --- Dermatology. --- Ophthalmology. --- Otorhinolaryngology. --- Plastic surgery. --- Medicine & Public Health. --- Plastic Surgery. --- Transplantation of organs, tissues, etc. --- Plastic surgeons --- Skin --- Surgery, Primitive --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Eye --- Diseases
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This book schematically discusses the available techniques for aesthetic vaginoplasty, including vagina rejuvenation and other related surgical and non-surgical approaches. By furthering our understanding of the field, it promotes a better surgical practice on aesthetic vaginal surgeries. More specifically, this book will enable surgeons to correctly assess patients, choose and plan procedures, and reproduce the most common surgical aesthetic vaginal procedures. Each chapter is written in a pedagogical way, promoting a direct applicability. For each surgical procedure discussed, it features topics such as consultation and patient’s intentions, clinical examination, anatomy and important landmarks, surgical technique and possible complications. Aesthetic Vaginal Plastic Surgery: A Practical Guide is intended for any medical professional interested in vagina aesthetic and rejuvenation procedures, especially those in the fields of plastic surgery, gynecology and urology.
Surgery. --- Gynecology. --- Urology. --- Plastic Surgery. --- Medicine --- Genitourinary organs --- Gynaecology --- Generative organs, Female --- Surgery, Primitive --- Diseases --- Gynoplasty. --- Surgery, Plastic --- Surgery --- Plastic surgery. --- Gynecology . --- Aesthetic surgery --- Cosmetic surgery --- Plastic surgery --- Reconstructive surgery --- Surgery, Aesthetic --- Surgery, Cosmetic --- Surgery, Reconstructive --- Transplantation of organs, tissues, etc. --- Plastic surgeons --- Rejuvenation. --- Vagina --- Vulva --- Gynecologic Surgical Procedures --- Reconstructive Surgical Procedures --- surgery --- methods. --- Endocrinology --- Organotherapy --- Youthfulness
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This monograph concerns the mathematical aspects of software reliability and quality assurance and consists of 11 technical papers in this emerging area. Included are the latest research results related to formal methods and design, automatic software testing, software verification and validation, coalgebra theory, automata theory, hybrid system and software reliability modeling and assessment.
fuzzy automata --- coalgebra --- fuzzy language --- bisimulation --- composition --- test data generation --- genetic algorithm --- specification-based testing --- regression testing --- mutation testing --- eventual property --- model checking --- Maude --- textual question answering --- visual question answering --- metamorphic testing --- metamorphic relations --- quality assessment --- software rejuvenation --- checkpointing --- optimal rejuvenation-trigger timing --- steady-state system availability --- phase expansion --- human-error factors --- petri net --- concurrent software systems --- model-checking --- data-flows --- software reliability model --- maximum likelihood estimation --- EM algorithm --- non-homogeneous Poisson process --- generalized failure count data --- moth flame optimization --- island-based model --- feature selection --- software defect prediction --- software reliability --- search-based test case generation --- branch coverage --- object-oriented --- deep learning --- long short-term memory --- project similarity and clustering --- cross-project prediction --- Nervos CKB --- consensus protocol --- UPPAAL
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In recent years, there has been a growing emphasis on minimally invasive procedures, which have revolutionized the safety and convenience of cosmetic surgery. Such procedures are often performed in combination with a series of minor procedures collectively providing results formerly possible only after major incisional surgery. As patients and physicians have become familiar with minimally invasive facial rejuvenation, there is growing interest in adapting techniques for use off the face. The same lasers, fillers, and other techniques that can improve the appearance of the forehead or lips are useful for the chest or hands. Of course, procedures have to be modified for use on the trunk and extremities. For instance, off the face, gentler treatment approaches can be preferable, in part because of reduced blood perfusion and slower wound healing. Body Rejuvenation is the first practical manual that describes off-the-face minimally invasive rejuvenation. Sections are organized by body area, and within each section, individual chapters contain step-by-step treatment algorithms. Chapters are brief and concise by design, so interested readers can readily obtain the information necessary to treat patients successfully. Expert authors share their experience with body rejuvenation, so that you don’t have to learn by trial and error.
Dermatology. --- Medicine. --- Surgery. --- Surgery, Plastic --- Therapeutics --- Specialties, Surgical --- Complementary Therapies --- Rejuvenation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Health Occupations --- Disciplines and Occupations --- Surgery & Anesthesiology --- Plastic Surgery --- Dermatology --- Health & Biological Sciences --- Surgery, Plastic. --- Surgery, Primitive --- Aesthetic surgery --- Cosmetic surgery --- Plastic surgery --- Reconstructive surgery --- Surgery, Aesthetic --- Surgery, Cosmetic --- Surgery, Reconstructive --- Plastic surgery. --- Medicine & Public Health. --- Plastic Surgery. --- Transplantation of organs, tissues, etc. --- Plastic surgeons --- Skin --- Diseases
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Defining the proper female body, seeking elective surgery for beauty, enjoying lavish spa treatments, and combating impotence might seem like today's celebrity infatuations. However, these preoccupations were very much alive in the early modern period. Valeria Finucci recounts the story of a well-known patron of arts and music in Renaissance Italy, Duke Vincenzo Gonzaga of Mantua (1562-1612), to examine the culture, fears, and captivations of his times. Using four notorious moments in Vincenzo's life, Finucci explores changing concepts of sexuality, reproduction, beauty, and aging. The first was Vincenzo's inability to consummate his earliest marriage and subsequent medical inquiry, which elucidates new concepts of female anatomy. Second, Vincenzo's interactions with Bolognese doctor Gaspare Tagliacozzi, the "father of plastic surgery," illuminate contemporary fascinations with elective procedures. Vincenzo's use of thermal spas explores the proliferation of holistic, noninvasive therapies to manage pain, detoxify, and rehabilitate what the medicine of the time could not address. And finally, Vincenzo's search for a cure for impotence later in life analyzes masculinity and aging. By examining letters, doctors' advice, reports, receipts, and travelogues, together with (and against) medical, herbal, theological, even legal publications of the period, Finucci describes an early modern cultural history of the pathology of human reproduction, the physiology of aging, and the science of rejuvenation as they affected a prince with a large ego and an even larger purse. In doing so, she deftly marries salacious tales with historical analysis to tell a broader story of Italian Renaissance cultural adjustments and obsessions.
traditional medicine --- medicine [discipline] --- Gonzaga, Vincenzo [Duke of Mantua] --- Medicine, Medieval --- Human body --- Renaissance --- Medicine --- Aging --- Rejuvenation --- Beauty, Personal --- Human reproduction --- Human physiology --- Reproduction --- Reproductive health --- Reproductive rights --- Beauty --- Complexion --- Grooming, Personal --- Grooming for women --- Personal beauty --- Personal grooming --- Toilet (Grooming) --- Hygiene --- Beauty culture --- Beauty shops --- Cosmetics --- Endocrinology --- Organotherapy --- Youthfulness --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Health Workforce --- Revival of letters --- Civilization --- History, Modern --- Civilization, Medieval --- Civilization, Modern --- Humanism --- Middle Ages --- Body, Human --- Human beings --- Body image --- Human anatomy --- Mind and body --- Medieval medicine --- Social aspects --- History. --- History --- Physiological effect --- Vincenzo --- Gonzaga, Vincenzo, --- Vincenzo Gonzaga, --- Health.
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Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
advanced glycated end products --- microRNAs --- n/a --- differentiation --- transcription --- skin absorption --- cellular quiescence --- lifespan --- longevity genes --- protein kinases --- self-renewal --- circadian --- blood–brain barrier --- aging-related disorders --- sirtuin-1 --- inflammation --- arterial aging --- reactive oxygen species --- electron microscopy --- reconstructed human skin --- rejuvenation --- low-dose fluvastatin and valsartan combination --- inflammaging --- hematopoietic stem cell aging --- cell cycle --- mitochondria --- ribose --- the nervous system --- nanomedicine --- proteostasis --- adult stem cells --- immunosenescence --- cell signaling --- mechanisms of quiescence maintenance --- metabolism --- aging --- melatonin --- diabetes --- mechanisms of quiescence entry and exit --- Drosophila melanogaster --- GSK3 (glycogen synthase kinase 3) --- blood-brain barrier
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Habitual statements in academic and journalistic fields on the growing inequality of our cities call for multiple reflections. There are numerous indicators of inequality, and territorial specificities give rise to important and subtle differences. What is less debatable is the spatial expansion of inequality (from more outlying, poorer countries to the most developed ones) and its generalization on all scales (from rural to urban areas, and from large metropolises to small cities). Mobility and housing lie at the root of many of these processes, which are represented by phenomena that are often interconnected, such as gentrification and the elite social classes; impoverishment and immigrants in search of work; and segregation and refugees; among many others. In this book, we try to offer a Spanish-based vision of what we call urban geographies in transition—that is, urban geographies in which the key stages, for the purpose of analysis, are the real estate bubble (1996–2007), the subsequent crisis (2008–2013), and the ensuing recovery (2014–2020), without overlooking the impact of the current COVID-19 crisis on the configuration of a new spatial order in cities.
Spanish cities --- economic crisis --- financialization --- gentrification --- housing crisis --- post-Fordist capitalism --- property bubble --- property repossession --- touristification --- pandemic --- real estate dispossession --- mortgage foreclosure --- evictions --- short-term rentals --- housing studies --- critical geography --- Canary Islands --- megaprojects --- neoliberalism --- urban development --- urban planning --- Santa Cruz de Tenerife --- Spain --- tourist gentrification --- real estate market --- international migrations --- tourist rejuvenation --- urban inequality --- master plans --- urban projects --- medium-sized cities --- neoliberal urbanism --- tourist housing --- Airbnb --- historic center --- population --- population growth --- spatial reconfiguration --- large urban areas --- post-crisis period --- urban project --- urban agents --- market urbanism --- speculation --- urban transformation --- central area --- Madrid --- residential segregation --- living conditions --- spatial inequalities --- urbanization process --- environmental justice --- urban parks --- ecosystem services --- Tarragona --- n/a
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