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Meningitis --- Leptomeningitis --- Central nervous system --- Neisseria meningitidis --- Diagnosis. --- Treatment. --- Diseases

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Gonorrhea is a sexually transmitted infection caused by the obligate human pathogen“Neisseria gonorrhoeae”. This Gram-negative diplococcus is highly infective due to its virulence factors: pili, Por proteins, Opa proteins, Rmp proteins, lipooligosaccharides and IgA protease. Despite existing guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issuesm such as the molecular mechanisms of the disease, diagnostic tests and different treatment strategies used to combat gonorrhea.

Neisseria gonorrhoeae --- gonorrhea --- antimicrobial resistance --- ciprofloxacin resistance --- precision treatment --- Neisseria species --- Neisseria meningitidis --- commensal --- pathogenesis --- host adaptation --- diagnostic --- microscopy --- culture --- NAAT --- point-of-care test --- microfluidic --- HDAC --- infection --- epigenetic --- H3K9ac --- macrophage --- survival --- cytokines --- chemokines --- AMR --- Neisseria meningitides --- commensal Neisseria --- Neisseria --- meningitidis --- kissing --- sharing --- microbiome --- transmission --- sexually transmitted infection --- diagnosis --- antibiotic treatment

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Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants.Key Features* Explains the basic principles of bacterial pathogenesis* Covers diverse aspects integrating regulat

Pathogenic bacteria. --- Virulence (Microbiology) --- BACTERIA --- VIRULENCE --- YERSINIA --- SALMONELLA --- SHIGELLA --- ESCHERICHIA --- VIBRIO CHOLERAE --- HELICOBACTER PYLORI --- NEISSERIA --- BORDETELLA --- HAEMOPHILUS INFLUENZAE --- STREPTOCOCCACEAE --- LISTERIA MONOCYTOGENES --- PATHOGENICITY

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Describing more than two centuries of epidemic meningitis, In the Blink of an Eye introduces a deadly and frightening bacterial infection of the brain—one that afflicts healthy children and young adults in dramatic fashion, often changing or taking lives in just hours or days.  Meningococcal meningitis is the culprit—causing sporadic cases as well as explosive, unpredictable outbreaks of disease throughout the world—leading to the deaths of dozens to hundreds of thousands every year.  Beginning with the case of a healthy teenage boy who rapidly succumbs to the disease, the book traces meningitis through its various social contexts.  From the acceptance of the germ theory of disease and the birth of the sister sciences of microbiology and immunology in the nineteenth century to the modern molecular era, the story traverses more than 200 years of medical history.  It leads us through the early descriptions of the disease, its impact on military forces, large outbreaks of meningitis in Africa and elsewhere, and the evolution of approaches to its treatment, control, and prevention.  In so doing, we witness the development of modern medical research and education, the discovery of antibiotics, the rapid emergence of drug-resistant bacteria, the invention of a novel class of vaccines, and learn the inner workings of disease processes and the human immune system.  The story of meningococcal meningitis—winding through the evolution of infectious diseases, the great European capitals of nineteenth century science, the Rockefeller Institute, the dye industry, Nazi Germany, military medicine, the Vietnam era, and prospects for an end to epidemic disease—parallels the rise of modern medical science.

Meningitis -- Molecular aspects. --- Meningitis, Meningococcal -- Diagnosis. --- Meningitis. --- Neisseria meningitidis -- Laboratory manuals. --- Meningitis, Cerebrospinal --- Biological Products --- Meningococcal Infections --- Meningitis, Bacterial --- Neisseriaceae Infections --- Central Nervous System Bacterial Infections --- Complex Mixtures --- Meningitis --- Chemicals and Drugs --- Central Nervous System Infections --- Gram-Negative Bacterial Infections --- Bacterial Infections --- Central Nervous System Diseases --- Bacterial Infections and Mycoses --- Nervous System Diseases --- Diseases --- Vaccines --- Meningitis, Meningococcal --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Epidemics --- Leptomeningitis --- History. --- Medicine. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Central nervous system --- Neisseria meningitidis --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases

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This timely collection of expert papers draws attention to the global burden of meningitis and the challenges faced by the WHO’s roadmap to defeat meningitis by 2030. The three main goals of the meningitis roadmap are to eliminate epidemics of bacterial meningitis, reduce cases and deaths from vaccine-preventable bacterial meningitis, and reduce disability and improve quality of life after meningitis of any cause. This book includes a wide range of original research and reviews on epidemiology and vaccination of bacterial meningitis that have direct relevance to advancing the goals of the roadmap.

meningitis --- child mortality --- neonatal sepsis --- global health --- global health estimates --- modelling --- Streptococcus pneumoniae --- Haemophilus influenzae --- Neisseria meningitidis --- bacterial meningitis --- S. pneumoniae --- N. meningitidis --- H. influenzae --- S. agalactiae --- conjugate vaccines --- post-vaccine surveillance --- vaccine --- Africa --- mathematical modelling --- susceptibility --- invasive bacterial infections --- complement --- genetic factors --- Streptococcus agalactiae --- group B streptococci --- capsule --- meningococcal group --- nongroupable --- meningococcal carriage --- invasive meningococcal disease --- meningococcal urethritis --- neonatal infections --- epidemiology --- antibiotic resistance --- etiologic diagnosis --- enterovirus --- group B Streptococcus --- neurological sequelae --- hearing loss --- seizure --- epilepsy --- hydrocephalus --- focal neurological deficit --- corticosteroid --- dexamethasone --- invasive pneumococcal disease --- pneumococcal conjugate vaccines --- serotypes --- vaccine impact --- pneumococcal meningitis --- serotype distribution --- PCV impact --- global --- meta-analysis --- surveillance --- meningococcus --- pneumococcus --- Hib --- group B streptococcus --- conjugate vaccine --- rapid diagnostic test --- national reference laboratory --- cerebrospinal fluid --- Niger --- Burkina Faso --- tuberculosis --- tuberculous meningitis --- TBM --- children --- impact of Hib conjugate vaccine --- Hia --- NTHi --- burden --- social and economic costs --- WHO meningitis roadmap --- disability --- n/a