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The discovery of ribozymes nearly 30 years ago triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in MILS 9. This book, written by 28 internationally recognized experts from 8 nations, provides a most up-to-date view and is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes in an authoritative and timely manner in 12 stimulating chapters, supported by nearly 1600 references, 13 tables, and 75 illustrations, mostly in color, metal ion-binding motifs, methods to detect and characterize metal ion-binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered.

Catalytic RNA. --- Ribonucleic acid enzymes --- Ribozymes --- RNA enzymes --- Non-coding RNA --- Nucleases

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The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exc

RNA --- Ribonucleases --- RNA-protein interactions --- Antibiotics --- Therapeutic use --- Physiological effect --- Anti-infective agents --- Microbial metabolites --- Allelopathic agents --- Antibiosis --- Pharmaceutical microbiology --- Phytoncides --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Protein binding --- RNases --- Nucleases --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose

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Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.

Gene silencing. --- Ribonucleases. --- RNA. --- Small interfering RNA -- Therapeutic use. --- RNA --- Ribonucleases --- Ribonucleoproteins --- Endoribonucleases --- RNA, Catalytic --- Nucleic Acids --- Ribonuclease P --- Enzymes --- RNA-Binding Proteins --- Nucleic Acids, Nucleotides, and Nucleosides --- Nucleoproteins --- Carrier Proteins --- Chemicals and Drugs --- Enzymes and Coenzymes --- Esterases --- Proteins --- Hydrolases --- Amino Acids, Peptides, and Proteins --- Human Anatomy & Physiology --- Chemistry --- Biochemistry --- Animal Biochemistry --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Proteins. --- Proteids --- RNases --- Life sciences. --- Proteomics. --- Life Sciences. --- Molecular biology --- Biosciences --- Sciences, Life --- Science --- Biomolecules --- Polypeptides --- Proteomics --- Nucleases

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Multi-scale Quantum Models for Biocatalysis: Modern Techniques and Applications explores various molecular modelling techniques and their applications in providing an understanding of the detailed mechanisms at play during biocatalysis in enzyme and ribozyme systems. These areas are reviewed by an international team of experts in theoretical, computational chemistry, and biophysics. This book has three sections that group together different aspects of multi-scale quantum simulations. The first section consists of four chapters that describe strategies for multi-scale quantum models and present an overview of the current state-of-the-art molecular modelling methodologies most relevant to handling these complex systems with quantum mechanics and molecular simulation. With five chapters, the second section mainly focuses on the current efforts to improve the accuracy of quantum calculations using simplified empirical model forms. The last section consists of five chapters focused on the applications of important biological systems using multi-scale quantum models. This book presents detailed reviews concerning the development of various techniques, including ab initio molecular dynamics, density functional theory, combined QM/MM methods, solvation models, force field methods, and free-energy estimation techniques, as well as successful applications of multi-scale methods in the biocatalysis systems including several protein enzymes and ribozymes. Multi-scale Quantum Models for Biocatalysis: Modern Techniques and Applications is an excellent source of information for research professionals involved in computational chemistry and physics, material science, nanotechnology, rational drug design and molecular biology. It is also likely to be of interest to graduate and undergraduate students exposed to these research areas.

Enzymes --Biotechnology. --- Molecules --Models. --- Enzymes --- Biocatalysis --- Molecules --- Animal Biochemistry --- Physical & Theoretical Chemistry --- Chemistry --- Human Anatomy & Physiology --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Biotechnology --- Models --- Enzymology. --- Catalytic RNA. --- Quantum chemistry. --- Mathematical models. --- Biophysics. --- Biological physics --- Models, Mathematical --- Chemistry, Quantum --- Ribonucleic acid enzymes --- Ribozymes --- RNA enzymes --- Chemistry. --- Chemistry, Physical and theoretical. --- Catalysis. --- Materials science. --- Nanotechnology. --- Theoretical and Computational Chemistry. --- Materials Science, general. --- Biology --- Medical sciences --- Physics --- Non-coding RNA --- Nucleases --- Biochemistry --- Simulation methods --- Chemistry, Physical and theoretical --- Quantum theory --- Excited state chemistry --- Materials. --- Molecular technology --- Nanoscale technology --- High technology --- Engineering --- Engineering materials --- Industrial materials --- Engineering design --- Manufacturing processes --- Activation (Chemistry) --- Surface chemistry --- Physical sciences --- Materials --- Material science --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry

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"The diversity of RNAs inside living cells is amazing. We have known of the more "classic" RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of the book to introduce this fascinating protein complex and to give a timely and rich account of its many functions"--Provided by publisher.

Ribonucleases. --- Ribosomes. --- RNA -- Metabolism. --- Ribonucleases --- RNA --- Ribosomes --- Metabolic Phenomena --- Biochemical Phenomena --- Nucleic Acids --- Exonucleases --- Chemical Phenomena --- Esterases --- Phenomena and Processes --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Exoribonucleases --- Metabolism --- RNA Stability --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Metabolism. --- Ribonucleoprotein particles --- Ribonucleic acid metabolism --- RNases --- Medicine. --- Molecular biology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Nucleases --- Health Workforce --- Biomedicine, general.