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Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue.

ergogenic aids --- cellular metabolism --- phosphagens --- sarcopenia --- cognition --- diabetes --- creatine synthesis deficiencies --- concussion --- traumatic brain injury --- spinal cord injury --- muscle atrophy --- rehabilitation --- pregnancy --- immunity --- anti-inflammatory --- antioxidant --- anticancer --- creatine --- nutritional supplements --- fertility --- newborn --- development --- brain injury --- post-viral fatigue syndrome --- chronic fatigue syndrome --- GAA --- creatine kinase --- dietary supplements --- exercise --- skeletal muscle --- glycemic control --- type 2 diabetes mellitus --- phosphorylcreatine --- dietary supplement --- ergogenic aid --- youth --- athletes --- osteoporosis --- osteosarcopenia --- frailty --- cachexia --- innate immunity --- adaptive immunity --- inflammation --- macrophage polarization --- cytotoxic T cells --- toll-like receptors --- vascular pathology --- cardiovascular disease --- oxidative stress --- vascular health --- female --- menstrual cycle --- hormones --- exercise performance --- menopause --- mood --- children --- height --- BMI-for-age --- stature-for-age --- growth --- phosphocreatine --- creatine transporter --- supplementation --- treatment --- heart --- heart failure --- ischemia --- myocardial infarction --- anthracycline --- cardiac toxicity --- energy metabolism --- cell survival --- bioinformatics --- systems biology --- cellular allostasis --- dynamic biosensor --- pleiotropic effects of creatine (Cr) supplementation --- inflammatory bowel diseases (IBD) --- ulcerative colitis --- Crohn’s disease --- creatine kinase (CK) --- phosphocreatine (PCr) --- creatine transporter (CrT) --- intestinal epithelial cell protection --- intestinal tissue protection --- creatine perfusion --- organ transplantation --- Adenosine mono-phosphate (AMP) --- activated protein kinase (AMPK) --- liver kinase B1 (LKB1) --- mitochondrial permeability transition pore (mPTP) --- reactive oxygen species (ROS) --- glucose transporter (GLUT) --- T cell antitumor immunity --- metabolic regulator --- cancer immunotherapy --- supplements --- muscle damage --- recovery --- immobilization --- atrophy --- muscular dystrophy --- amyotrophic lateral sclerosis --- Parkinson’s Disease --- cardiopulmonary disease --- mitochondrial cytopathy --- hypertrophy --- athletic performance --- weightlifting --- resistance exercise --- training --- muscular power --- muscular adaptation --- muscle fatigue --- adipose tissue --- muscle strength --- physiological adaptation --- mitochondria --- thermogenesis --- MAP kinase signaling system --- sodium-chloride-dependent neurotransmitter symporters --- signal transduction --- intradialytic creatine supplementation --- hemodialysis --- muscle --- protein energy wasting --- clinical trial --- muscle weakness --- chronic fatigue --- cognitive impairment --- depression --- anemia --- resistance training --- sports nutrition --- strength --- toxicity --- methylation --- hyperhomocysteinemia --- neuromodulation --- MCDA --- mitochondriopathia --- cardiac infarction --- long COVID --- hypoxia --- stroke --- neurodegenerative diseases --- noncommunicable disease --- adenosine 5′-monopnophosphate-activated protein kinase --- anthracyclines --- creatine supplementation --- cardiac signaling --- cardiotoxicity --- doxorubicin --- soy --- vegetarian/vegan diet --- amino acids --- dietary ingredients --- performance