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Periodical
Bioelectrochemistry and bioenergetics.
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ISSN: 03024598 18728049 Year: 1992 Publisher: Lausanne, Switzerland : Amsterdam ; New York : Elsevier Sequoia, Elsevier Science


Book
Kinetic Theory and Swarming Tools to Modeling Complex Systems—Symmetry problems in the Science of Living Systems
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ISBN: 3039288806 3039288792 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This MPDI book comprises a number of selected contributions to a Special Issue devoted to the modeling and simulation of living systems based on developments in kinetic mathematical tools. The focus is on a fascinating research field which cannot be tackled by the approach of the so-called hard sciences—specifically mathematics—without the invention of new methods in view of a new mathematical theory. The contents proposed by eight contributions witness the growing interest of scientists this field. The first contribution is an editorial paper which presents the motivations for studying the mathematics and physics of living systems within the framework an interdisciplinary approach, where mathematics and physics interact with specific fields of the class of systems object of modeling and simulations. The different contributions refer to economy, collective learning, cell motion, vehicular traffic, crowd dynamics, and social swarms. The key problem towards modeling consists in capturing the complexity features of living systems. All articles refer to large systems of interaction living entities and follow, towards modeling, a common rationale which consists firstly in representing the system by a probability distribution over the microscopic state of the said entities, secondly, in deriving a general mathematical structure deemed to provide the conceptual basis for the derivation of models and, finally, in implementing the said structure by models of interactions at the microscopic scale. Therefore, the modeling approach transfers the dynamics at the low scale to collective behaviors. Interactions are modeled by theoretical tools of stochastic game theory. Overall, the interested reader will find, in the contents, a forward look comprising various research perspectives and issues, followed by hints on to tackle these.

Molecular and cellular signaling
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ISBN: 128071607X 9786610716074 0387260153 0387221301 9780387221304 Year: 2005 Publisher: New York : Springer,

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A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding. About the Author: Martin Beckerman, Ph.D. is Senior Scientist at the Center forMartin Beckerman, PhD, is a senior research scientist at the Department of Energy/National Nuclear Security Administration’s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has authored over 130 publications and has been included in 1400 citations.


Book
Het vreemde van de aarde: strakke natuurwetten en onberekenbaar leven.
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ISBN: 9028910808 9789028910805 Year: 1986 Publisher: Kapellen,


Book
Simulation with Entropy Thermodynamics
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Beyond its identification with the second law of thermodynamics, entropy is a formidable tool for describing systems in their relationship with their environment. This book proposes to go through some of these situations where the formulation of entropy, and more precisely, the production of entropy in out-of-equilibrium processes, makes it possible to forge an approach to the behavior of very different systems. Whether for dimensioning structures; influencing parameter variability; or optimizing power, efficiency, or waste heat reduction, simulations based on entropy production offer a tool that is both compact and reliable. In the case of systems marked by complexity, it appears to be the only way. In that sense, realistic optimization can be carried out, integrating within the same framework both the system and all the constraints and boundary conditions that define it. Simulations based on entropy give the researcher a powerful analytical framework that crosses the disciplines of physics and links them together.

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