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Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.

Cancer --- Oncogenes --- Genomics --- Proteomics --- Oncogènes --- Génomique --- Protéomique --- Genetic aspects --- Handbooks, manuals, etc. --- Aspect génétique --- Guides, manuels, etc. --- Cancer -- Genetic aspects -- Handbooks, manuals, etc. --- Genomics -- Handbooks, manuals, etc. --- Oncogenes -- Handbooks, manuals, etc. --- Proteomics -- Handbooks, manuals, etc. --- Genes, Neoplasm --- Diseases --- Biology --- Computational Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Natural Science Disciplines --- Disciplines and Occupations --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Genome research --- Genomes --- Onc genes --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Research --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Molecular biology --- Proteins --- Molecular genetics --- Cancer genes --- Proto-oncogenes --- Oncology  .

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Cancer -- Genetic aspects. --- Cancer genes. --- Gene expression. --- Gene expression --- Cancer genes --- Cancer --- Genetic Techniques --- Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Investigative Techniques --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genome --- Genetic Structures --- Disciplines and Occupations --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Genes, Neoplasm --- Gene Expression Profiling --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Genetic aspects --- Gene therapy. --- Therapy, Gene --- Expression --- Medicine. --- Laboratory medicine. --- Oncology. --- Pathology. --- Medicine & Public Health. --- Laboratory Medicine. --- Genetic engineering --- Therapeutics --- Genetic regulation --- Oncology  . --- Medical laboratories. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis

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Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Carcinogenesis. --- Foreign workers --Germany (West). --- German language --Social aspects. --- German language --Syntax --Study and teaching --Foreign speakers. --- Grammar, Comparative and general. --- Language and languages --Variation. --- Retrovirus infections. --- Viral carcinogenesis. --- Retroviruses --- Oncogenic viruses --- Viral carcinogenesis --- RNA Viruses --- Vertebrate Viruses --- Genes --- Diseases --- Viruses --- Genome Components --- Genome --- Organisms --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Retroviridae --- Oncogenic Viruses --- Genes, Neoplasm --- Neoplasms --- Biology --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Oncology --- Language and languages --- Grammar, Comparative and general --- German language --- Foreign workers --- Languages & Literatures --- Philology & Linguistics --- Variation --- Study and teaching --- Syntax --- Foreign speakers --- Social aspects --- Retroviruses. --- Oncogenic viruses. --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Cancer-causing viruses --- Cancer viruses --- Oncoviruses (Oncogenic viruses) --- Tumor viruses --- Tumorigenic viruses --- Medicine. --- Cancer research. --- Medical microbiology. --- Virology. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- RNA viruses --- Microbial carcinogenesis --- Oncology. --- Medical virology. --- Microbiology. --- Medical microbiology --- Virology --- Virus diseases --- Tumors --- Microbial biology --- Microorganisms --- Microbiology --- Cancer research

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Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting.

BRCA genes. --- Breast -- Cancer -- Chemotherapy. --- Cancer -- Gene therapy. --- Trastuzumab. --- Trastuzumab --- BRCA genes --- Cancer --- Breast --- Antibodies --- Neoplasms by Site --- Genes, erbB --- Therapeutics --- Investigative Techniques --- Breast Diseases --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Skin Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Neoplasms --- Immunoglobulins --- Proto-Oncogenes --- Skin and Connective Tissue Diseases --- Immunoproteins --- Diseases --- Oncogenes --- Serum Globulins --- Chemical Actions and Uses --- Disciplines and Occupations --- Genes, Neoplasm --- Blood Proteins --- Chemicals and Drugs --- Globulins --- Proteins --- Genes --- Methods --- Antibodies, Monoclonal --- Breast Neoplasms --- Genes, erbB-2 --- Antineoplastic Agents --- Molecular Targeted Therapy --- Drug Therapy --- Pharmacology --- Amino Acids, Peptides, and Proteins --- Genome Components --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Medicine --- Health & Biological Sciences --- Oncology --- Pharmacy, Therapeutics, & Pharmacology --- Gene therapy --- Chemotherapy --- Cancer. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Immunology. --- Antibodies. --- Pharmacology. --- Internal medicine. --- Oncology. --- Biomedicine. --- Pharmacology/Toxicology. --- Cancer Research. --- Internal Medicine. --- Toxicology. --- Oncology  . --- Monoclonal antibodies. --- Medicine, Internal --- Immunobiology --- Life sciences --- Serology --- Monoclonal immunoglobulins --- Molecular cloning --- Tumors --- Chemicals --- Poisoning --- Poisons --- Toxicology --- Immune globulins --- Immune serum globulin --- Blood proteins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Physiological effect