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A compilation of 12 original research articles and a review on the development of instrumental and immunoanalytical methods for mycotoxins; on the enhancement of sample preparation and selection to improve method applicability; and on practical applications of analytical methods in laboratory fungal cultures, cereal and feed samples, surface water (as a novel matrix of mycotoxins as emerging surface water contaminants), and during mycotoxin decontamination by bacteria. Target analyte mycotoxins include aflatoxins, deoxynivalenol, diacetoxyscirpenol, fumonisins, fusarenone-X, HT-2 toxins, nivalenol, ochratoxins, sterigmatocystin, T-2 toxin, and zearalenone.

aflatoxins --- laboratory culture --- extraction --- HPLC --- recovery --- detection limits --- frequency mixing technology --- immunofiltration --- magnetic beads --- mycotoxin --- type B trichothecenes --- modified mycotoxins --- isomer separation --- method validation --- ochratoxin A --- fluorescence --- G-quadruplex --- biosensor --- computation --- simulation --- mycotoxins --- feed --- modified QuEChERS --- LC-MS/MS --- zearalenone --- immunochromatographic assay --- semi-quantification --- quantification --- aflatoxin B1 --- sterigmatocystin --- lactobacilli --- mycotoxin binding --- detoxification --- lactic acid bacteria --- colorimetric detection --- rapid tests --- ELISA --- lateral flow assays --- microfluidics --- nano-materials --- food safety --- commercialization --- immunosensor --- optical waveguide lightmode spectroscopy --- label-free detection --- planar waveguide sensor --- polarisation interferometer --- limit of detection --- competitive immunoassay --- fluorescence detection --- high-performance liquid chromatography --- total internal reflection ellipsometry --- aflatoxin --- chicken feed --- representative sampling --- improved aflatoxin test procedure --- validation --- n/a

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The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with “free radicals” as the common denominator.

guanine --- guanyl radical --- tautomerism --- guanine radical cation --- oligonucleotides --- DNA --- G-quadruplex --- time-resolved spectroscopies --- reactive oxygen species (ROS) --- oxidation --- catalase mimics --- peroxide --- diiron-peroxo complexes --- structure/activity --- kinetic studies --- biomimetic chemistry --- cysteine --- ketone reduction --- free radicals --- pulse radiolysis --- kinetics --- DNA oxidation --- DNA hole transfer --- molecular dynamics --- quantum dynamics --- electron transfer --- charge transfer --- quantum coherence --- chemiluminescence --- reaction mechanisms --- singlet oxygen --- reactive oxygen species --- light emission --- crosslink --- dimerization --- protein oxidation --- radicals --- di-tyrosine --- di-tryptophan --- disulfides --- thiols --- aggregation --- proteomics --- mass spectrometry --- collagen --- riboflavin --- hyaluronic acid --- EPR spectroscopy --- keratoconus --- STEM --- DNA biosensor --- chemical nucleases --- DNA-drug interaction --- copper complexes --- metallodrugs --- MEP pathway --- antibiotics --- IspH --- LytB --- [4Fe-4S] cluster --- reductive dehydroxylation --- bioorganometallic intermediate --- inhibitors --- methionine --- neighboring group effect --- hydroxyl radical --- triplet state of carboxybenzophenone --- one-electron oxidants --- laser flash photolysis --- peptides --- proteins --- n/a

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Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.

transcription factor --- n/a --- transcription --- self-incompatibility --- cytogenetics --- epigenetics --- selenocysteine --- tea --- AP-2? --- nonsense-mediated decay --- transcriptomics --- Akt1 --- promoter --- cell metabolism --- pediveliger larvae --- Patau Syndrome --- tristetraprolin (TTP) --- long non-coding RNA (lncRNA) --- pregnancy --- G-quadruplex --- glioblastoma --- placenta --- PRDM gene family --- circRNA-disease associations --- bioadhesive --- gene expression --- Crassostrea gigas --- transcription regulation --- cell differentiation --- RNA interference --- transcriptome --- inflammatory response --- FOXO1 --- Adiponectin --- liquid chromatograph-tandem mass spectrometer (LC-MS/MS) --- selenium --- selenocysteine insertion sequence --- inflammation --- selenoproteins --- research methods --- nutritional status --- structures and functions --- CRISPR/Cas9 --- fertilization --- melanin --- differentially expressed genes --- tyrosinase --- posttranscriptional regulation --- major depressive disorder --- human malignancies --- pathway --- CDKN1C --- transcription factors --- p57Kip2 --- enhancer activity --- mouse --- disorders --- high-throughput RNA sequencing (RNA-Seq) --- TCGA data analysis --- RNA-seq --- heterogeneous network --- insect --- and drug design --- therapeutic targets --- mechanisms --- obesity --- Pacific oyster --- Rsh regulon --- common pathway --- Pax3 --- somatic mutations --- nutrition --- molecular docking --- bioinformatics --- interactome --- long non-coding RNAs --- transcriptional regulation --- Pteria penguin (Röding --- Adiponectin receptors --- transcriptome profiling --- 1798) --- N-acyl-l-homoserine lactone --- ppGpp --- tumorigenesis --- sphingomonads --- human --- disease --- adenosine and uridine-rich elements (AREs) --- progress and prospects --- miR-25-3p --- acute leukemia --- Novosphingobium pentaromativorans US6-1 --- microscopy --- cancer --- molecular pathways --- causal inference --- Pteria penguin (Röding