Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume.

Erythrocytes. --- Erythropoiesis --- Regulation.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Reticulocytes --- Erythrocytes --- Erythropoiesis --- senescence --- Clearance --- Anaemia --- Membrane Physiology --- Rheology --- Microfluidics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.

Anemia --Treatment. --- Erythropoiesis --Molecular aspects. --- Erythropoiesis. --- Erythropoietin --Therapautic use. --- Erythropoietin. --- Erythropoietin --- Erythropoiesis --- Anemia --- Drug Therapy --- Erythropoietin, Recombinant --- Pharmacology --- Colony-Stimulating Factors --- Therapeutics --- Hematopoiesis --- Hematologic Diseases --- Biological Science Disciplines --- Recombinant Proteins --- Blood Physiological Processes --- Hemic and Lymphatic Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hematopoietic Cell Growth Factors --- Proteins --- Cell Differentiation --- Natural Science Disciplines --- Glycoproteins --- Amino Acids, Peptides, and Proteins --- Blood Physiological Phenomena --- Diseases --- Cell Physiological Processes --- Cytokines --- Disciplines and Occupations --- Intercellular Signaling Peptides and Proteins --- Chemicals and Drugs --- Cell Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Peptides --- Biological Factors --- Pharmacy, Therapeutics, & Pharmacology --- Physiology --- Health & Biological Sciences --- Human Anatomy & Physiology --- Therapeutic use --- Molecular aspects --- Treatment --- Therapeutic use. --- Molecular aspects. --- Treatment. --- Anaemia --- Medicine. --- Pharmacology. --- Endocrinology. --- Sports medicine. --- Cell biology. --- Biomedicine. --- Pharmacology/Toxicology. --- Cell Biology. --- Sports Medicine. --- Blood --- Molecular biology --- Colony-stimulating factors (Physiology) --- Hematopoietic growth factors --- Toxicology. --- Cytology. --- Internal medicine --- Hormones --- Athletic medicine --- Athletics --- Medicine and sports --- Physical education and training --- Sports --- Medicine --- Sports sciences --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Poisoning --- Poisons --- Medical aspects --- Toxicology --- Endocrinology . --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Iron is essential for most forms of life, including humans. On the other hand, iron is also potentially toxic. Therefore, the control of iron metabolism and maintenance of iron hemostasis is an crucial part of many aspects of human health and disease. Iron deficiency anemia is one of the most common diseases worldwide, but there are also anemias associated with chronic diseases, and other acquired or hereditary defects. Understanding the control of iron metabolism is furthermore important for understanding diseases of iron overload, like hemochromatosis. This booklet is designed for physicians, clinical lab personnel and medical students. It gives an overview about the principles of regulation of iron metabolism and erythropoiesis. In addition, the various disturbances of iron metabolism and the associated clinical findings are described. Special focus lies on the differential diagnosis of the disorders, and the approaches of therapy. Finally, a comprehensive schedule of tests is included available for the determination of iron metabolism-related parameters in serum/plasma and blood, with indication of methodologies applied and reference ranges.

Anemia. --- Erythropoiesis -- physiology. --- Iron -- Metabolism -- Laboratory manuals. --- Iron -- Metabolism. --- Iron Metabolism Disorders. --- Iron --- Anemia --- Metabolic Diseases --- Hematopoiesis --- Hematologic Diseases --- Metabolic Phenomena --- Metals, Heavy --- Biological Science Disciplines --- Transition Elements --- Natural Science Disciplines --- Hemic and Lymphatic Diseases --- Phenomena and Processes --- Nutritional and Metabolic Diseases --- Elements --- Blood Physiological Processes --- Cell Differentiation --- Metals --- Blood Physiological Phenomena --- Inorganic Chemicals --- Disciplines and Occupations --- Diseases --- Cell Physiological Processes --- Chemicals and Drugs --- Cell Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Erythropoiesis --- Physiology --- Iron Metabolism Disorders --- Metabolism --- Medicine --- Health & Biological Sciences --- Pathology --- Disorder --- Metabolic Phenomenon --- Metabolic Process --- Metabolism Concepts --- Metabolism Phenomena --- Process, Metabolic --- Processes, Metabolic --- Anabolism --- Catabolism --- Metabolic Concepts --- Metabolic Processes --- Concept, Metabolic --- Concept, Metabolism --- Concepts, Metabolic --- Concepts, Metabolism --- Metabolic Concept --- Metabolism Concept --- Phenomena, Metabolic --- Phenomena, Metabolism --- Phenomenon, Metabolic --- Disorder, Iron Metabolism --- Disorders, Iron Metabolism --- Iron Metabolism Disorder --- Metabolism Disorder, Iron --- Metabolism Disorders, Iron --- Anemias --- Erythropoieses --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Chemicals, Inorganic --- Blood Physiological Concepts --- Blood Physiological Phenomenon --- Physiology, Blood --- Blood Physiologic Processes --- Blood Physiology --- Blood Physiological Concept --- Blood Physiological Phenomenas --- Concept, Blood Physiological --- Concepts, Blood Physiological --- Phenomena, Blood Physiological --- Phenomenon, Blood Physiological --- Physiologic Processes, Blood --- Physiological Concept, Blood --- Physiological Concepts, Blood --- Physiological Phenomenon, Blood --- Processes, Blood Physiologic --- Processes, Blood Physiological --- Blood --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Elements, Transition --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Heavy Metals --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Haematopoiesis --- Hematopoiesis, Medullary --- Medullary Hematopoiesis --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Anaemia --- Circulatory and Respiratory Physiological Phenomenon --- Physiology, Circulatory and Respiratory --- Circulatory and Respiratory Physiology --- physiology --- Medicine. --- Hematology. --- Metabolic diseases. --- Nephrology. --- Rheumatology. --- Medicine & Public Health. --- Metabolic Diseases. --- Internal medicine --- Connective tissues --- Joints --- Kidneys --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Haematology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Disorders.