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With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest, "which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Key Features * Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods * Serves as a laboratory manual for bench chemists * Includes a chapter on linkers to assist in choice of linking strategy * Discusses strengths and limitations of the various methods * Contains a structural index showing functional group transformations in solid-phase synthesis.
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Chemistry --- Combinatorial chemistry --- Molecular theory --- Combinatorial Chemistry Techniques. --- Chemistry.
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Biochips. --- Bioreactors --- Molecular computers --- Combinatorial chemistry
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This is a guide to the major areas of combinatorial chemistry from an experimental and conceptual point of view. Its implications for many areas of chemistry and biology are covered.
Combinatorial Chemistry Techniques --- Investigative Techniques --- Technology, Pharmaceutical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Pharmaceutic Technology --- Pharmaceutical Technology --- Pharmacy Technology --- Technology, Pharmaceutic --- Technology, Pharmacy --- Chemistry, Pharmaceutical --- Drug Industry --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Chemistry Technic, Combinatorial --- Chemistry Technics, Combinatorial --- Chemistry Technique, Combinatorial --- Combinatorial Chemistry Technic --- Combinatorial Chemistry Technics --- Combinatorial Chemistry Technique --- Technic, Combinatorial Chemistry --- Technics, Combinatorial Chemistry --- Technique, Combinatorial Chemistry --- Chemistry Techniques, Combinatorial --- Techniques, Combinatorial Chemistry --- Gene Library --- Peptide Library --- Oligonucleotide Array Sequence Analysis --- High-Throughput Screening Assays --- Click Chemistry --- Combinational chemistry.
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Biosensors --- Aparells i instruments mèdics --- Detectors --- Ressonància de plasmons superficials --- Biochips. --- Bioreactors --- Molecular computers --- Combinatorial chemistry
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The tradition of setting new trends in medicinal chemistry continued at the 13th Symposium where topics included chemical and biological diversity, new paradigms in drug action, and new insights in receptor mechanisms. Other topics of great interest discussed, and included in these proceedings, are the discoveries in green chemistry, the interface between organic synthesis and biosynthesis, the growing problem of resistant micro-organisms and the possibilities to identify new, and better, antibiotics.
Drugs --- Pharmacology --- Pharmaceutical chemistry --- Design --- Pharmacology, Experimental --- Combinatorial chemistry --- Drug development
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Biochips --- Cooperating objects (Computer systems) --- Testing. --- Automatic control. --- Bioreactors --- Molecular computers --- Combinatorial chemistry
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This book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery.
Biochemical engineering. --- Combinatorial chemistry. --- Gene expression. --- Biochemical Engineering. --- Combinatorial Libraries. --- Gene Expression.
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CMOS Biotechnology reviews the recent research and developments joining CMOS technology with biology. Written by leading researchers these chapters delve into four areas including: Microfluidics for electrical engineers CMOS Actuators CMOS Electrical Sensors CMOS Optical Sensors Bioanalytical instruments have been miniaturized on ICs to study various biophenomena or to actuate biosystems. These bio-lab-on-IC systems utilize the IC to facilitate faster, repeatable, and standardized biological experiments at low cost with a small volume of biological sample. CMOS Biotechnology will interest electrical engineers, bioengineers, biophysicists as well as researchers in MEMS, bioMEMS, microelectronics, microfluidics, and circuits and systems.
Metal oxide semiconductors, Complementary. --- Biochips. --- Bioreactors --- Molecular computers --- Combinatorial chemistry --- CMOS (Electronics) --- Complementary metal oxide semiconductors --- Semiconductors, Complementary metal oxide --- Digital electronics --- Logic circuits --- Transistor-transistor logic circuits
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