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Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid.  Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of  oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina.  It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina.   A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of  cerium oxide nanoparticle reduction of oxidative stress.  Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of  prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell.  The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Choroid diseases. --- Ophthalmology. --- Retinal diseases. --- Retina --- Uveal Diseases --- Eye Diseases --- Stress, Physiological --- Metabolism --- Metabolic Phenomena --- Physiological Processes --- Diseases --- Phenomena and Processes --- Physiological Phenomena --- Oxidative Stress --- Choroid Diseases --- Retinal Diseases --- Biology --- Medicine --- Health & Biological Sciences --- Cytology --- Ophthalmology & Optometry --- Eye --- Vision disorders. --- Diseases. --- Defective vision --- Disorders of vision --- Impaired vision --- Visual disorders --- Visual function disorders --- Visual handicaps --- Visual impairments --- Diseases and defects --- Life sciences. --- Cell biology. --- Oxidative stress. --- Life Sciences. --- Oxidative Stress. --- Cell Biology. --- Communicative disorders --- Disabilities --- Sensory disorders --- Ophthalmology --- Cytology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Oxidation-reduction reaction --- Stress (Physiology)

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Fundus oculi --- Retina --- Uveal Diseases --- Eye Diseases --- Medicine --- Posterior Eye Segment --- Blood Vessels --- Eye --- Health Occupations --- Cardiovascular System --- Diseases --- Anatomy --- Sense Organs --- Disciplines and Occupations --- Choroid Diseases --- Pathology --- Retinal Diseases --- Fundus Oculi --- Vitreous Body --- Retinal Vessels --- Health & Biological Sciences --- Ophthalmology & Optometry --- Atlases --- Retinal Blood Vessels --- Pecten Oculi --- Retinal Vasculature --- Retinal Blood Vessel --- Retinal Vasculatures --- Retinal Vessel --- Vasculature, Retinal --- Vessel, Retinal --- Vessel, Retinal Blood --- Retinal Vasculitis --- Vitreous Humor --- Bodies, Vitreous --- Body, Vitreous --- Humor, Vitreous --- Humors, Vitreous --- Vitreous Bodies --- Vitreous Humors --- Disease, Retinal --- Diseases, Retinal --- Retinal Disease --- Color Vision Defects --- Pathologies --- Disease --- Choroidal Diseases --- Choroid Disease --- Choroidal Disease --- Disease, Choroid --- Disease, Choroidal --- Diseases, Choroid --- Diseases, Choroidal --- Organ, Sense --- Organs, Sense --- Sense Organ --- Anatomies --- Circulatory System --- Cardiovascular Systems --- Circulatory Systems --- Blood Circulation --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Eyes --- Blood Vessel --- Vessel, Blood --- Vessels, Blood --- Eye Segment, Posterior --- Eye Segments, Posterior --- Posterior Eye Segments --- Segment, Posterior Eye --- Segments, Posterior Eye --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Health Workforce --- Eye Disorders --- Eye Disease --- Eye Disorder --- Ophthalmology --- Disease, Uveal --- Diseases, Uveal --- Uveal Disease --- Ora Serrata --- Angioid Streaks --- Electroretinography --- Posterior segment (Eye) --- Eyegrounds --- Fundus of the eye --- Ocular fundus --- pathology --- Fundus of the Eye --- Ocular Fundus --- Fundus, Ocular --- Disease. --- Atlases.