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The book focuses on a global problem challenging the health systems. Trypanosoma cruzi infections are transmitted by cone-nosed triatomine bugs, by blood transfusion and congenitally from mothers to their offspring. The American Trypanosomiasis affects 20 million people; among them a significant parcel (< 1/3) will develop Chagas disease in the heart and digestive tract, where the immune system effector cells destroy target host cells. Genotype modifications resulting from transfer of minicircle sequence kDNA from the parasite into the host ́s genome may explain the autoimmune pathogenesis.

Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions.

Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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This title critically reviews old and new literature, help to create greater awareness of the disease in the US and helps in the evaluation of certain epidemiological and public health issues. During the first half of the 20th century, Chagas disease was assumed to be absent from the U.S. and considered an exotic disease, until the first two indigenous cases were discovered, almost simultaneously, in Texas, 1955. Since that time four indigenous cases have been documented in several places in the country. Although the disease is still considered uncommon in the US, this disease is not

Chagas' disease -- Epidemiology. --- Chagas Disease -- epidemiology. --- Chagas' disease --- Public Health --- Medicine --- Health & Biological Sciences --- Communicable Diseases --- Infectious Diseases --- Epidemiology --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.

Conenoses as carriers of disease. --- Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis --- Insects as carriers of disease --- Invertebrates. --- Parasitology. --- Veterinary microbiology. --- Invertebrate Zoology. --- Veterinary Microbiology. --- Parasitologia --- Microbiologia veterinària --- Malaltia de Chagas --- Agricultural microbiology --- Medical microbiology --- Communicable diseases in animals --- Biology --- Invertebrata --- Animals

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Esta esmerada obra – que reúne um conjunto iconográfico singular, fruto de ampla pesquisa, e uma compilação dos mais expressivos documentos relativos à vida e à obra de Carlos Chagas – conduz o leitor através das múltiplas dimensões da trajetória biográfica desse distinto pesquisador e suas variadas facetas. Por se tratar de um livro composto essencialmente de imagens, contém pouco texto próprio, mas não menos importante, como o que descreve Chagas como um dos líderes do movimento que preconizava a intervenção do Estado na saúde pública. À época, o Brasil era considerado ‘doente’ não porque fosse país tropical ou formado por mestiços, mas porque não havia políticas preventivas na área da saúde. Chagas, pois, além de brilhante cientista, foi também um destacado sanitarista. A obra é constituída de capítulos que abrangem sua infância, sua formação médica, as campanhas que realizou contra a malária, a descoberta da doença que leva seu nome, os estudos sobre tal assunto, a polêmica em torno da nova enfermidade, a expedição que realizou à Amazônia, sua atuação como diretor do IOC e como gestor da saúde pública federal, sua atividade como professor, alguns aspectos de sua vida pessoal e familiar e, por fim, premiações e títulos que conquistou ao longo de sua carreira. Os conteúdos históricos fundamentais sobre cada tema estimularão o leitor a percorrê-lo através da narrativa das imagens. A publicação tem o mérito de contribuir para a propagação da obra de Carlos Chagas, que, longe de situar-se em um passado distante, apresenta plena atualidade com o presente da agenda sanitária e política relacionada às chamadas doenças tropicais negligenciadas, e à sua associação com a pobreza nos países em desenvolvimento.

Physicians --- Medical scientists --- Chagas' disease --- Diseases --- Chagas Disease --- History. --- Transmission. --- Causes and theories of causation. --- history --- Chagas, Carlos, --- Brazil. --- Aetiology --- Etiology --- Pathology --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis --- Biomedical scientists --- Health scientists --- Life scientists --- Medical research personnel --- Ribeiro Justiniano Chagas, Carlos, --- al-Barāzīl --- Barāzīl --- Brasil --- Brasile --- Brasilia --- Brasilië --- Brasilien --- Brazili --- Brazili Federativlă Respubliki --- Brazilia --- Brazilië --- Brazilii︠a︡ --- Brazilii︠a︡ Federativ Respublikaḣy --- Braziliya --- Braziliya Federativ Respublikası --- Brazilská federativní republika --- Brazylia --- Brésil --- Burajiru --- Federale Republiek van Brasilië --- Federative Republic of Brazil --- Federativna republika Brazil --- Federativna republika Brazilii︠a︡ --- Federat︠s︡iėm Respublikė Brazil --- Fedėratyŭnai︠a︡ Rėspublika Brazilii︠a︡ --- Gweriniaeth Ffederal Brasil --- Pa-hsi --- Pa-se --- Pa-se Liân-pang Kiōng-hô-kok --- Pederatibong Republika sa Brasil --- Pindorama --- República Federal del Brasil --- Republica Federale di u Brasile --- Republica Federativa del Brazil --- República Federativa do Brasil --- Rèpublica fèdèrativa du Brèsil --- Republik Kevreel Brazil --- République fédérative du Brésil --- Tantasqa Republika Wrasil --- Tetã Pindorama --- Wrasil --- Федэратыўная Рэспубліка Бразілія --- Федеративна република Бразилия --- Федерациэм Республикэ Бразил --- Бразил --- Бразили --- Бразили Федеративлă Республики --- Бразилия --- Бразилия Федератив Республикаhы --- Бразілія --- البرازيل --- برازيل --- ブラジル