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Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short­ term, symptomatic, and surrogate indicator outcomes. Yet RA is a life-long disor­der with the majority of impact on an individual patient many years following onset. Further, even in the short-term, researchers and rheumatologists have tended to emphasize measurements of disease activity such as joint counts, ESR and physi­cian's opinion as to the amount of disease activity present. It is only relatively recently that measures of structural damage, quality of life and impact on broad domains of health have been given increasing emphasis. Also, the significance of early treatment of RA in order to optimise long-term outcomes has a relatively short history [1]. We have been focussed on the disease processes as surrogates for long­ term outcomes. Until the short-term process measures are validated as surrogates of long-term effects we should also turn our attention to outcomes of disease and the impact of our management on those outcomes [2). In our view, this book is especially timely. We are at the dawn of a revolution in the management of RA and other complex immunological inflammatory disorders because their molecular, genetic and environmental mechanisms are being unrav­elled. In the process, we are revealing a substantial number of novel and significant targets for pharmacotherapy.

Medicine & Public Health. --- Medicine/Public Health, general. --- Medicine. --- Médecine --- Antirheumatic agents. --- Rheumatoid arthritis -- Chemotherapy. --- Rheumatoid arthritis. --- Antirheumatic agents --- Rheumatoid arthritis --- Rheumatic Diseases --- Autoimmune Diseases --- Therapeutic Uses --- Arthritis --- Pharmacologic Actions --- Musculoskeletal Diseases --- Connective Tissue Diseases --- Joint Diseases --- Immune System Diseases --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Skin and Connective Tissue Diseases --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Chemotherapy. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Anti-rheumatic agents --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Analgesics --- Anti-inflammatory agents --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce

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The volume focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter discusses the biological rationale in great detail, including in vitro work and work in animal models, and where appropriate, results from clinical trials. The book is written by an international authorship of experts in this field. It is of interest to rheumatologists, immunologists, internists, investigators in immunology and rheumatology as well as the pharmaceutical industry.

Medicine. --- Rheumatology. --- Toxicology. --- Rheumatoid arthritis --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Autoimmune Diseases --- Rheumatic Diseases --- Arthritis --- Therapeutic Uses --- Immune System Diseases --- Pharmacologic Actions --- Connective Tissue Diseases --- Musculoskeletal Diseases --- Joint Diseases --- Chemical Actions and Uses --- Diseases --- Skin and Connective Tissue Diseases --- Chemicals and Drugs --- Musculoskeletal System Diseases --- Medicine --- Health & Biological Sciences --- Research --- Treatment --- Rheumotolgy. --- Research. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Immunology. --- Pharmacology. --- Cell biology. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Cell Biology. --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Immunobiology --- Life sciences --- Serology --- Internal medicine --- Connective tissues --- Joints --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.

Parasitology. --- Infectious diseases. --- Drug resistance. --- Bioinformatics. --- Virology. --- Infectious Diseases. --- Drug Resistance. --- Microbiology --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Resistance to drugs --- Pharmacology --- Data processing --- Drug resistance in microorganisms. --- Communicable Diseases. --- Antimalarials. --- Antibiotic resistance in microorganisms --- Antibiotics resistance in microorganisms --- Bacterial resistance to antibiotics --- Drug resistance in micro-organisms --- Microbial drug resistance --- Resistance to drugs in microorganisms --- Microorganisms --- Anti-Malarials --- Antimalarial Agents --- Antimalarial Drugs --- Agents, Antimalarial --- Anti Malarials --- Drugs, Antimalarial --- Malaria --- Plasmodium --- Antirheumatic Agents --- Infectious Diseases --- Communicable Disease --- Disease, Communicable --- Disease, Infectious --- Diseases, Communicable --- Diseases, Infectious --- Infectious Disease --- Disease Outbreaks --- Disease Transmission, Infectious --- Resistance, Drug --- Pharmacogenetics --- Effect of drugs on --- Anti-Malarial --- Antimalarial --- Antimalarial Agent --- Antimalarial Drug --- Agent, Antimalarial --- Anti Malarial --- Drug, Antimalarial --- Resistència als medicaments --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic --- Farmacoresistència --- Farmacologia --- Resistència a la insulina --- Efecte dels medicaments sobre els microorganismes