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Antioxidants. --- Active oxygen. --- Antioxidants.

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This publication contains an extensive overview of free radicals and diseases, including both basic science approaches and clinical applications. The research of the last decades has contributed substantially to the understanding role and function of these metabolites. It is the aim of the editors to include a large variety of biological models ranging from yeast over mitochondria, isolated cells and cell culture models to animals and humans. The topics discussed focus on the function and integrity of mitochondria under oxidative conditions, the role of protein oxidation and proteolysis in the

Free radicals (Chemistry) --- Active oxygen --- Pathophysiology. --- Free radicals --- Gene expression --- Cellular metabolism --- Pathophysiology

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Active oxygen. --- Oxygen radicals --- Reactive oxygen --- Singlet oxygen --- Superperoxide anion --- Free radicals (Chemistry) --- Ionization of gases --- Oxygen

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This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized.Key Features:* Reactive species as intracellular messengers* Redox regulation of cellular responses* Clinical implications of redox signaling and antioxidant therapy

Active oxygen in the body. --- Active oxygen --- Antioxidants --- Cellular signal transduction. --- Genetic regulation. --- Pathophysiology. --- Physiological effect. --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Information theory in biology --- Chemical inhibitors --- Oxygen in the body --- Regulation

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This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds.   Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage.   The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Oxidative stress --- Active oxygen in the body --- Active oxygen --- Membrane lipids --- Veterinary pathophysiology --- Stress, Physiological --- Metabolism --- Physiological Processes --- Metabolic Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Oxidative Stress --- Health & Biological Sciences --- Biology --- Veterinary Medicine --- Cytology --- Pathophysiology --- Physiological effect --- Peroxidation --- Veterinary medicine. --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Life sciences. --- Biochemistry. --- Cell biology. --- Oxidative stress. --- Zoology. --- Life Sciences. --- Oxidative Stress. --- Cell Biology. --- Animal Biochemistry. --- Veterinary Medicine. --- Medicine --- Animal health --- Animals --- Domestic animals --- Livestock --- Diseases --- Losses --- Cytology. --- Veterinary Medicine/Veterinary Science. --- Natural history --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Oxidation-reduction reaction --- Stress (Physiology)