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Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Drug receptors. --- G proteins. --- Ligands (Biochemistry). --- G proteins --- Ligands (Biochemistry) --- Drug receptors --- Investigative Techniques --- Proteins --- Chemistry, Pharmaceutical --- Cell Physiological Processes --- Metabolic Phenomena --- Laboratory Chemicals --- Receptors, Cell Surface --- Biochemical Processes --- Natural Science Disciplines --- Amino Acids, Peptides, and Proteins --- Biochemical Phenomena --- Membrane Proteins --- Specialty Uses of Chemicals --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Pharmacology --- Chemical Processes --- Phenomena and Processes --- Cell Physiological Phenomena --- Chemicals and Drugs --- Chemical Phenomena --- Biological Science Disciplines --- Chemical Actions and Uses --- Chemistry --- Drug Discovery --- Ligands --- Metabolism --- Receptors, G-Protein-Coupled --- Signal Transduction --- Receptors, Drug --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neurology --- Animal Biochemistry --- Drugs --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Receptors --- Medicine. --- Human physiology. --- Neurosciences. --- Pharmacology. --- Neurology. --- Neurobiology. --- Biomedicine. --- Pharmacology/Toxicology. --- Human Physiology. --- Cell receptors --- Membrane proteins --- Biochemistry --- Toxicology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Nervous system --- Neuropsychiatry --- Neurosciences --- Chemicals --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Neuroscience --- Diseases --- Toxicology --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect

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This book focuses on the way in which second-wave feminism has been represented in American popular culture, and on the effects that these representations have had on feminism as a political movement.

Droits des femmes dans la littérature --- Feminism in literature --- Feminisme in de literatuur --- Féminisme dans la littérature --- Rôle selon le sexe dans la littérature --- Seksuele rolpatronen in de literatuur --- Sex role in literature --- Updike, John, 1932-2009. Witches of Eastwick --- Vrouwenrechten in de literatuur --- Women's rights in literature --- Social policy --- Fiction --- Thematology --- Sociology of the family. Sociology of sexuality --- Atwood, Margaret --- French, Marilyn --- United States --- Canada --- American fiction --- 20th century --- History and criticism --- Feminism and literature --- History --- Atwood, Margaret Eleanor --- Feminist fiction [American ] --- Irving, John --- Feminism and motion pictures --- Best sellers --- Feminist fiction, American --- Women's rights in literature. --- Feminism in literature. --- Sex role in literature. --- History and criticism. --- Atwood, Margaret, --- Irving, John, --- French, Marilyn, --- Updike, John. --- Bestsellers --- Books --- Books and reading --- Feminist theory in literature --- Motion pictures and feminism --- Motion pictures --- Ruders, Poul, --- United States of America --- Feminism --- Equal opportunities --- Gender roles --- Literature --- Writers --- Women's literature --- Book

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The ability to obtain health care is fundamental to the security, stability, and well-being of poor families. Government-sponsored programs provide temporary support, but as families leave welfare for work, they find themselves without access to coverage or care. The low-wage jobs that individuals in transition are typically able to secure provide few benefits yet often disqualify employees from receiving federal aid. Drawing upon statistical data and in-depth interviews with over five hundred families in Oregon, Karen Seccombe and Kim Hoffman assess the ways in which welfare reform affects the well-being of adults and children who leave the program for work. We hear of asthmatic children whose uninsured but working mothers cannot obtain the preventive medicines to keep them well, and stories of pregnant women receiving little or no prenatal care who end up in emergency rooms with life-threatening conditions. Representative of poor communities nationwide, the vivid stories recounted here illuminate the critical relationship between health insurance coverage and the ability to transition from welfare to work.

Health care reform. --- Health care reform --- Health insurance --- Health services accessibility --- Health Care Reform --- Interviews as Topic --- Insurance, Health --- Socioeconomic Factors --- Health Services Accessibility --- Oregon --- Social Welfare --- Delivery of Health Care --- Northwestern United States --- Health Planning --- Health Policy --- Data Collection --- Population Characteristics --- Sociology --- Insurance --- Patient Care Management --- Epidemiologic Methods --- Social Sciences --- Health Care Evaluation Mechanisms --- Financing, Organized --- Information Science --- Public Policy --- Health Care Quality, Access, and Evaluation --- Health Care Economics and Organizations --- United States --- Health Care --- Health Services Administration --- Quality of Health Care --- Anthropology, Education, Sociology and Social Phenomena --- Public Health --- North America --- Investigative Techniques --- Social Control Policies --- Economics --- Social Control, Formal --- Americas --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Policy --- Environment and Public Health --- Geographic Locations --- Geographicals --- Access to health care --- Accessibility of health services --- Availability of health services --- Medical care --- Health plans, Prepaid --- Medical care, Prepaid --- Medical insurance --- Prepaid health plans --- Prepaid medical care --- Sickness insurance --- Health reform --- Health system reform --- Healthcare reform --- Medical care reform --- Reform of health care delivery --- Reform of medical care delivery --- Access --- Ambulance service --- Home care services --- Hospitals --- Medically uninsured persons --- Surgical clinics --- Medical policy --- Prospective payment --- Emergency services --- Outpatient services --- Rehabilitation services --- Accessibility, Health Services --- Contraceptive Availability --- Health Services Geographic Accessibility --- Program Accessibility --- Access to Health Care --- Accessibility of Health Services --- Availability of Health Services --- Accessibility, Program --- Availability, Contraceptive --- Health Services Availability --- Medically Underserved Area --- Healthcare Reform --- Health Care Reforms --- Healthcare Reforms --- Reform, Health Care --- Reform, Healthcare --- Reforms, Health Care --- Reforms, Healthcare --- Group Health Insurance --- Health Insurance --- Health Insurance, Voluntary --- Health Insurance, Group --- Insurance, Group Health --- Insurance, Voluntary Health --- Voluntary Health Insurance --- Group Interviews --- Interviewers --- Interviews, Telephone --- Oral History as Topic --- Group Interview --- Interview, Group --- Interview, Telephone --- Interviewer --- Interviews, Group --- Telephone Interview --- Telephone Interviews --- Community Services --- Services, Community --- Community Service --- Service, Community --- Welfare, Social --- Public Assistance --- Factors, Socioeconomic --- High-Income Population --- Inequalities --- Land Tenure --- Standard of Living --- Factor, Socioeconomic --- High Income Population --- High-Income Populations --- Inequality --- Living Standard --- Living Standards --- Population, High-Income --- Populations, High-Income --- Socioeconomic Factor --- Tenure, Land --- Access To Medicines --- Access to Contraception --- Access to Health Services --- Access to Medications --- Access to Therapy --- Access to Treatment --- Contraception Access --- Contraceptive Access --- Medication Access --- Access To Medicine --- Access to Contraceptions --- Access to Medication --- Access to Therapies --- Access to Treatments --- Access, Contraception --- Access, Contraceptive --- Access, Medication --- Contraception, Access to --- Contraceptive Accesses --- Medication Accesses --- Medication, Access to --- Therapy, Access to --- Treatment, Access to --- Social Inequalities --- Social Inequality --- Inequalities, Social --- Inequality, Social

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The investigation of sudden or unexplained death of children represents a unique medical and forensic area of study. Children have unique anatomic and functional characteristics that must be recognized and understood by the medical investigator. Further complicating this process is the fact that the anatomic structure, composition and function of various organs and organ systems in the pediatric population change throughout the developmental stages of childhood. The disease processes, reactions to trauma and risk factors for accidental death and homicide change from infancy through adolescence. Forensic Pathology of Infancy and Childhood provides an authoritative, comprehensive reference text devoted to the medicolegal investigation of sudden unexpected death in children. With contributions from internationally renowned experts, individual chapters focus on specific unique causes and organ systems with detailed accounts of the changes in fatal diseases, risk factors of causes of sudden death, and responses to fatal trauma that occur as a child grows from neonatal stage through infancy, toddlerhood, childhood and adolescence. This text is an essential reference resource for forensic pathologists, medical examiner offices, pediatric pathologists, pediatric hospitals, anatomic pathologists and those in training as well as those in related legal professions.

Medicine. --- Forensic science. --- Forensic medicine. --- Pathology. --- Pediatrics. --- Biomedicine. --- Forensic Science. --- Forensic Medicine. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Forensic medicine --- Injuries (Law) --- Jurisprudence, Medical --- Legal medicine --- Forensic sciences --- Medical laws and legislation --- Criminalistics --- Forensic science --- Science --- Criminal investigation --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Health and hygiene --- Forensic pathology. --- Pathology, Forensic --- Medical jurisprudence --- Coroners --- Medical examiners (Law) --- Medical jurisprudence. --- Forensic sciences.

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This thoroughly updated new edition of the classic practical textbook provides a user-friendly, authoritative guide to evaluation of common cardiovascular symptoms and evaluation and management of common cardiovascular conditions. Coverage also includes clinical challenges such as management of chronic anticoagulation, assessing and minimizing cardiac risk in noncardiac surgery, and management of the cardiac surgery patient. Numerous tables and algorithms help readers find information quickly and aid in clinical decision-making. Practical Cardiology, Evaluation and Treatment of Common Cardiovascular Disorders reflects the current American College of Cardiology/American Heart Association guidelines and provides a concise yet comprehensive handbook presents practical information on the common cardiovascular problems that clinicians encounter daily.

Cardiology. --- Heart --- Internal medicine --- Diseases --- Cardiologia --- Medicina interna --- Anestèsia en cardiologia --- Cardiologia geriàtrica --- Cardiologia pediàtrica --- Cardiologia veterinària --- Medicina intensiva en cardiologia --- Malalties cardiovasculars --- Malalties del cor --- Malalties vasculars