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The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burdens of catastrophic expenses on families due to TB. Eliminating TB in the Asia-Pacific region, which has 62% of all estimated TB patients globally, will require innovation, rigorous research, and sustained investment. This special issue connects original research and viewpoints on pertinent approaches for improving TB care and prevention in the Asia-Pacific region.

pediatric TB --- verbal screening --- contact tracing --- resources --- sputum --- health promotion --- operational research --- indigenous population --- multidrug-resistant tuberculosis --- household contact --- screening --- TB diagnosis --- yield --- operations research --- contacts --- contact investigation --- MDR-TB --- public–private mix model --- public–private partnership --- missing cases --- SORT IT --- TB diagnostics --- laboratory methods --- case detection --- Xpert Ultra --- STR --- Bangladesh regimen --- tuberculosis --- post-tuberculosis morbidity and mortality --- TB preventive therapy --- latent TB infection --- Asia Pacific --- rifapentine-isoniazid --- incidence --- household contacts tracing --- End TB --- sustainable development goals --- South-East Asia --- Western Pacific Region --- national TB program --- socio-economic determinants --- diabetes mellitus --- TB-DM --- adverse drug reactions --- unfavourable outcome --- lymph node TB --- bone TB --- TB elimination --- extrapulmonary tuberculosis --- private sector --- intermediary agency --- referral --- notification --- Viet Nam --- active case finding --- community outreach --- Indonesia --- key population --- innovation --- TB REACH --- community health workers --- mobile X-ray screening --- TB --- chest X-ray --- active TB case-finding --- diagnostic algorithm --- n/a --- public-private mix model --- public-private partnership