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This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section deals with the systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section describes the engineering concepts and design strategies of biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell. Finally, the book offers expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Life Sciences. --- Systems Biology. --- Biomedical Engineering. --- Biological Networks, Systems Biology. --- Biochemical Engineering. --- Mathematical and Computational Biology. --- Computational Biology/Bioinformatics. --- Life sciences. --- Biochemical engineering. --- Bioinformatics. --- Biological models. --- Biomedical engineering. --- Sciences de la vie --- Génie biochimique --- Bio-informatique --- Modèles biologiques --- Génie biomédical --- Biology --- Health & Biological Sciences --- Biology - General --- Systems biology. --- Bioengineering. --- Biotechnology. --- Biological engineering --- Life science engineering --- Biomathematics. --- Biological systems. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Chemical engineering --- Genetic engineering --- Engineering --- Synthetic biology --- Biomedical Engineering and Bioengineering. --- Bio-informatics --- Biological informatics --- Information science --- Systems biology --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Medicine --- Models, Biological --- Data processing --- Mathematics --- Biosystems --- Systems, Biological --- System theory --- Philosophy

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The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulation become indispensable not only to uncover the molecular mechanisms of the processes, but to perform useful predictions. To this end, the E‑Cell System, a multi‑algorithm, multi‑timescale object‑oriented simulation platform, can be used to construct predictive virtual biological systems. Gene regulatory and biochemical networks that constitute a sub‑ or a whole cellular system can be constructed using the E‑Cell System to perform qualitative and quantitative analyses. The purpose of E‑Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E‑Cell System version 3 in terms of the software features and its usage. While the publicly available E‑Cell Simulation Environment version 3 User's Manual provides the technical details of model building and scripting, it does not describe some of the underlying concepts of the E‑Cell System. The first part of the book addresses this issue by providing the basic concepts of modeling and simulation with the E‑Cell System.

Metabolism. --- Phenomena and Processes --- Metabolic Phenomena --- Models, Theoretical --- Computing Methodologies --- Cells --- Biological Science Disciplines --- Anatomy --- Natural Science Disciplines --- Investigative Techniques --- Information Science --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Computer Simulation --- Models, Biological --- Cellular Structures --- Metabolic Networks and Pathways --- Physiology --- Metabolism --- Cell Physiological Phenomena --- Biology --- Health & Biological Sciences --- Cytology --- Biophysics --- Mathematical models. --- Cell biology --- Cellular biology --- Medicine. --- Molecular biology. --- Biomedicine. --- Molecular Medicine. --- Biomedicine general. --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology