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Les cytokines occupent une place centrale dans la régulation des processus immunitaires et inflammatoires, dans la transformation tissulaire et dans le développement embryonnaire. Elles appartiennent à un groupe de protéines de faible poids moléculaire et sont produites par de nombreux types cellulaires différents. Les cytokines agissent rarement seules et généralement par l’intermédiaire de processus paracrines et autocrines. Chacune de ces cytokines est capable de stimuler la production d’une multitude d’autres cytokines, générant ainsi un véritable réseau pouvant interagir avec d’autres régulateurs cellulaires come les hormones et les neuropeptides.
Médiateurs solubles de l’immunité, de l’inflammation et de la croissance cellulaire, les cytokines sont utilisées avec succès dans la thérapie des maladies tumorales, d’infections virales et parasitaires et de quelques rares déficiences immunitaires et congénitales. Leur production excessive ou incontrôlée peut, par ailleurs, être associée au développement d’infections, de maladies autoimmunes et de néoplasies. En particulier, ces médiateurs sont impliqués, du moins en partie, dans le mécanisme par lequel certaines poussières respirables induisent une fibrose pulmonaire interstitielle.
Cette maladie du parenchyme pulmonaire est caractérisée par une accumulation exagérée des cellules mésenchymateuses et de leur production collagénique. Elle est orchestrée par l’intermédiaire de macrophages pulmonaires potentiellement responsables d’une libération massive de cytokines et autres facteurs de croissance.
Dans le cadre de notre travail, nous nous sommes plus spécialement attachés à l’étude de l’alvéolite fibrosante induite par des poussières de métaux durs dont l’étiologie n’est pas encore élucidée.
L’objectif de ce mémoire est double : développer d’une part, un modèle de culture de macrophages qui puisse apprécier la libération de deux cytokines (TNF-α et Il-1), d’un facteur de croissance (la fibronectine) et d’un inhibiteur des protéinases à cystéine (cyctatine-c) et comparer d’autre part, à partir de ce modèle, l’activité de particules de cobalt pur ou associées au carbure de tungstène

Cobalt --- Lung --- Culture Techniques --- Growth Substances --- Proteases Inhibitors --- Occupational Exposure --- Pneumoconiosis

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Enzymology --- Enzymes protéolytiques --- Peptide hydrolases --- Peptidohydrolases --- Proteases --- Proteolytic enzymes --- Proteolytiques [Enzymes ] --- Proteolytische enzymen --- Enzymes proteolytiques. --- Retrovirus --- Virus de l'immunodeficience humaine --- Enzymes proteolytiques --- Enzymes. --- Enzymes --- Retroviruses --- Retrovirus - Enzymes. --- Retrovirus - Enzymes --- Proteinases --- Virus, bacterial

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Molecular biology --- Proteolytic enzymes --- Lysosomes --- Dental caries --- Bone resorption --- Biodegradation --- Congresses --- -Dental caries --- -Lysosomes --- -Proteolytic enzymes --- -Peptide hydrolases --- Proteases --- Hydrolases --- Cell organelles --- Caries, Dental --- Cariology --- Cavities, Dental --- Decay, Tooth --- Dental cavities --- Tooth decay --- Teeth --- Osteolysis --- Bone remodeling --- Bones --- Resorption (Physiology) --- Diseases --- -Congresses --- Proteolytic enzymes - Congresses --- Lysosomes - Congresses --- Dental caries - Congresses --- Bone resorption - Congresses --- Biodegradation - congresses --- Molecular biology - Congresses

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This book offers comprehensive, unified coverage of proteolytic enzymes, which are useful in a multitude of important physiological processes. The emphasis here is on the practical aspects of the handling, characterization, inhibition, and use of these enzymes. The book provides general advice as well as specific examples. Written in a clear, readable style, the volume is an excellent resource for scientists who study proteases, or those who use them as probes for experimental and therapeutic purposes.

Proteolytic enzymes --- Peptide Hydrolases. --- Peptide hydrolases --- Proteases --- Esteroproteases --- Peptidases --- Proteinases --- Proteolytic Enzymes --- Gene Products, pol --- Proteolytic enzymes. --- Peptide Hydrolases --- #WSCH:WBIO --- 612.321 --- Hydrolases --- 612.321 Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- Basic Sciences. Chemistry --- Biochemistry --- Proteins and Enzymes. --- AMINO ACID SEQUENCE --- CONFORMATION --- PROTEINS --- PROTEINASES --- ENZYMES --- PEPTIDES --- SOLUBILIZATION --- BIOLOGICAL STUDIES --- PREPARATION

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 330 and 331) cover all current knowledge concern

Proteolytic enzymes. --- DNA --- Enzyme Stability --- Enzymes --- Pyrococcus furiosus --- Pyrococcus --- Enzymes and Coenzymes --- Technology, Pharmaceutical --- Protein Stability --- Nucleic Acids --- Nucleic Acids, Nucleotides, and Nucleosides --- Thermococcaceae --- Biochemical Phenomena --- Chemicals and Drugs --- Investigative Techniques --- Chemical Phenomena --- Thermococcales --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Euryarchaeota --- Archaea --- Organisms --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Temperature --- Hydrolases --- Weather --- Atmosphere --- Thermodynamics --- Meteorological Concepts --- Physical Phenomena --- Ecological and Environmental Phenomena --- Environment --- Biological Phenomena --- Environment and Public Health --- Health Care --- Bacteria --- Hot Temperature --- Peptide Hydrolases --- Archaea. --- Biochemistry -- Periodicals. --- Biochemistry. --- Enzymes -- Periodicals. --- Enzymes. --- Microorganisms. --- Glycoside Hydrolases --- Adaptation, Physiological --- Physiological Processes --- Adaptation, Biological --- Physiological Phenomena --- Biological Processes --- Microorganisms --- Effect of heat on. --- Effect of temperature on. --- Esteroproteases --- Peptidases --- Proteases --- Proteinases --- Proteolytic Enzymes --- Heat --- Hot Temperatures --- Temperature, Hot --- Temperatures, Hot --- Eubacteria --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- Environmental Impact --- Environmental Impacts --- Impact, Environmental --- Impacts, Environmental --- Environments --- Meteorologic Factors --- Meteorological Factors --- Concept, Meteorological --- Concepts, Meteorological --- Factor, Meteorologic --- Factor, Meteorological --- Factors, Meteorologic --- Factors, Meteorological --- Meteorologic Factor --- Meteorological Concept --- Meteorological Factor --- Biocatalysts --- Thermodynamic --- Ecological and Environmental Concepts --- Ecological and Environmental Processes --- Atmospheres --- Fog --- Fogs --- Temperatures --- Physical Phenomenon --- Physical Process --- Physical Concepts --- Physical Processes --- Concept, Physical --- Concepts, Physical --- Phenomena, Physical --- Phenomenon, Physical --- Physical Concept --- Process, Physical --- Processes, Physical --- Coenzymes and Enzymes --- Peptide hydrolases --- Micro-organisms, Effect of temperature on --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Physiological effect --- ARCHAEA --- HEAT --- ENZYMES --- BIOLOGICAL EFFECTS --- Dna nucleotidyltransferases --- Isomerases --- Oxidoreductases --- Temperature effects (biological)