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Computer programming in biomedicine --- Biomedical computer programs --- Computer programming in statistics --- Medical statistics

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  This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.    .

Medicine. --- Toxicology. --- Biomedicine. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Biomedicine general. --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemicals --- Clinical sciences --- Medical profession --- Toxicology --- Molecular biology. --- Pharmacology. --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Health Workforce --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Noxae --- Drug-Related Side Effects and Adverse Reactions --- Chemically-Induced Disorders

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The aim of these lecture notes is to give an introduction to several mathematical models and methods that can be used to describe the behaviour of living systems. This emerging field of application intrinsically requires the handling of phenomena occurring at different spatial scales and hence the use of multiscale methods. Modelling and simulating the mechanisms that cells use to move, self-organise and develop in tissues is not only fundamental to an understanding of embryonic development, but is also relevant in tissue engineering and in other environmental and industrial processes involving the growth and homeostasis of biological systems. Growth and organization processes are also important in many tissue degeneration and regeneration processes, such as tumour growth, tissue vascularization, heart and muscle functionality, and cardio-vascular diseases.

Mathematics. --- Applied mathematics. --- Engineering mathematics. --- Biomathematics. --- Mathematical and Computational Biology. --- Biomedicine general. --- Applications of Mathematics. --- Biology --- Engineering --- Engineering analysis --- Math --- Mathematics --- Mathematical analysis --- Science --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Mathematical models. --- Biological models --- Biomathematics --- Biomedicine, general.

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Plus que jamais, les oncologues ont besoin de l'apport de la biologie, d'abord pour comprendre les cancers, mais surtout pour les traiter. Plus de 600 essais thérapeutiques sont en cours en 2010 pour évaluer les thérapies ciblées. Il est maintenant bien établi que le cancer est, d'une certaine façon, une maladie de la signalisation cellulaire : les cellules cancéreuses détournent à leur profit les messages que s'échangent les cellules, masquent ou surexpriment les récepteurs de ces messages, miment de mille façons les voies intracellulaires qui leur permettent de proliférer et d'envahir les tissus voisins ou distants. Afin de s'y retrouver dans le dédale des voies de signalisation, dans la profusion des récepteurs et des signaux concourant à l'oncogenèse, le professeur Jacques Robert propose une vision d'ensemble, certes simplifiée et didactique, mais assez complète, des voies de transmission de l'information entre les cellules et à l'intérieur des cellules. Pour une bonne partie, ce livre repose sur les cours délivrés en Master 1 et 2 à l'université de Bordeaux 2, accompagnés de schémas longuement réfléchis. Les voies de signalisation y sont décortiquées une à une, mais sans jamais esquiver la complexité de leurs interconnexions. La présentation de chaque voie est suivie d'une brève description des altérations rencontrées dans les cancers et des approches pharmacologiques ciblées qui peuvent être mises en oeuvre pour y remédier. Les mécanismes de base de la biologie moléculaire, qui permettent d'expliquer les perturbations des voies de signalisation, font l'objet d'annexes didactiques. Cet ouvrage, accompagné d'un CD-Rom présentant 113 schémas en couleur, véritable outil de référence pour l'enseignement, se veut le compagnon de l'oncologue dans sa quête de nouvelles thérapeutiques anticancéreuses.

Medicine & Public Health. --- Medicine/Public Health, general. --- Oncology. --- Cancer Research. --- Pharmacology/Toxicology. --- Biological Microscopy. --- Biomedicine general. --- Medicine. --- Toxicology. --- Microscopy. --- Médecine --- Cancérologie --- Toxicologie --- Microscopie --- Neoplasms --- Neoplastic Stem Cells --- etiology --- Neoplasms - etiology

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Research on law's relationship with time has flourished over the past decade. This edited collection aims to put law and time scholarship into wider context, advancing conversations on time and temporalities between socio-legal scholars, anthropologists, sociologists, geographers and historians. Through a diverse range of contributions, the collection explores how legal modalities of time emerge and have effects within wider clusters of social and political action. Themes include: law’s diverse roles in maintaining linear historicist models of time; law’s participation in the materialisation of times; and the unsteady effects of temporal pluralism and polytemporalities in law. De-naturalising the ‘time’ in law and time scholarship, this collection positions time as something that can be enacted and materialised as well as experienced, with distinct implications for questions of social justice.

Time (Law) --- Social aspects --- Social aspects. --- Civil procedure --- Notice (Law) --- Limitation of actions --- Time (Law) - Social aspects --- alternative medicine --- traditional medicine --- law --- medicine --- Ayurveda --- Biomedicine --- Europe --- Health care --- Modernity --- Public health --- Temporalities