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Bio-process engineering --- Biochemical engineering --- Biochemische techniek --- Bioprocess engineering --- Genetic engineering --- Genetische manipulatie --- Génie biochimique --- Génie génétique --- Ingénierie génétique --- Chemistry --- Biotechnology --- Chemical engineering

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Bio-process engineering --- Biochemical engineering --- Biochemische techniek --- Bioprocess engineering --- Génie biochimique --- Biochemistry. --- Biotechnology. --- Chemical Engineering. --- Engineering, Chemical --- Biotechnologies --- Biochemistry --- Biotechnology --- Chemical Engineering --- Carbon dioxide. --- Fungi. --- Animal cells --- Genes --- Immobilization (biological cell) --- Process control and dynamics --- Process optimization --- Proteins

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This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

Biosynthesis. --- Polyketides. --- Alkaloids. --- Chemistry. --- Biochemical engineering. --- Organic chemistry. --- Biochemistry. --- Biochemical Engineering. --- Organic Chemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Composition

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This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in vitro and in vivo selection. Unlike ribozymes, DNAzymes do not occur in nature. Although the catalytic activity of nucleic acid enzymes is usually much slower than that of proteins, nucleic acid enzymes with comparable catalytic activity have been obtained using stringent selection processes. The key advantages of these enzymes: they are e.g. smaller, easier to produce and purify than proteins, and can withstand denaturation, e.g. by heat. Over the last few years, the number of publications on the applications of enzymatic nucleic acids has grown steadily. Summarizing the fundamentals and applications of these acids, this book will not only be an excellent resource for experts in the field but will also guide young researchers just starting out in this significant area.

Biochemical engineering. --- Nucleic acids. --- Enzymes. --- Biochemical Engineering. --- Nucleic Acid Chemistry. --- Enzymology. --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Polynucleotides --- Biomolecules --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Enzymes --- Chemistry --- Biochemical engineering --- Nucleic acids

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Bio-process engineering --- Biochemical engineering --- Biochemische techniek --- Bioprocess engineering --- Génie biochimique --- Biotechnology. --- Microbiological Techniques. --- Microbiologic Technic --- Microbiologic Technics --- Microbiologic Technique --- Microbiological Technics --- Technic, Microbiologic --- Technics, Microbiological --- Technique, Microbiologic --- Techniques, Microbiologic --- Microbiologic Techniques --- Microbiological Technic --- Microbiological Technique --- Technic, Microbiological --- Technics, Microbiologic --- Technique, Microbiological --- Techniques, Microbiological --- Microbiology --- Biotechnologies --- methods --- Biotechnology --- Microbiological Techniques