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Small GTPases play a key role in many aspects of contemporary cell biology: control of cell growth and differentiation; regulation of cell adhesion and cell movement; the organization of the actin cytoskeleton; and the regulation of intracellular vesicular transport.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.

Guanosine triphosphatase. --- ras Proteins. --- ras Proteins --- Monomeric GTP-Binding Proteins --- GTP-Binding Proteins --- Intracellular Signaling Peptides and Proteins --- Peptides --- Carrier Proteins --- GTP Phosphohydrolases --- Proteins --- Amino Acids, Peptides, and Proteins --- Acid Anhydride Hydrolases --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Ras proteins. --- G proteins. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Guanosine triphosphatase --- Guanosine-trifosfatase --- Guanosinetriphosphatase --- Trifosfatase [Guanosine-] --- Triphosphatase [Guanosine] --- rho GTP-Binding Proteins --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- G-Protein --- GTP-Binding Protein --- GTP-Regulatory Protein --- Guanine Nucleotide Coupling Protein --- G-Proteins --- GTP-Regulatory Proteins --- Guanine Nucleotide Regulatory Proteins --- G Protein --- G Proteins --- GTP Binding Protein --- GTP Binding Proteins --- GTP Regulatory Protein --- GTP Regulatory Proteins --- Protein, GTP-Binding --- Protein, GTP-Regulatory --- Proteins, GTP-Binding --- Proteins, GTP-Regulatory --- Intracellular Signaling Peptides --- Intracellular Signaling Proteins --- Peptides, Intracellular Signaling --- Proteins, Intracellular Signaling --- Signaling Peptides, Intracellular --- Signaling Proteins, Intracellular --- P21 (rho)Protein --- rho GTP-Binding Protein --- rho Protein P21 --- rho G-Proteins --- rho GTPases --- rho Small GTP-Binding Proteins --- G-Proteins, rho --- GTP-Binding Protein, rho --- GTP-Binding Proteins, rho --- GTPases, rho --- P21, rho Protein --- rho G Proteins --- rho GTP Binding Protein --- rho GTP Binding Proteins --- rho Small GTP Binding Proteins --- GTP Phosphohydrolase --- GTPase --- GTPases --- Guanosine Triphosphate Phosphohydrolases --- Guanosinetriphosphatases --- Phosphohydrolase, GTP --- Phosphohydrolases, GTP --- Phosphohydrolases, Guanosine Triphosphate --- Triphosphate Phosphohydrolases, Guanosine --- ras-Related G-Proteins --- ras-Related GTP-Binding Proteins --- G-Proteins, Monomeric --- GTP-Binding Proteins, Monomeric --- Monomeric G-Proteins --- Small G-Proteins --- Small GTPases --- ras-Related GTPases --- G Proteins, Monomeric --- G-Proteins, Small --- G-Proteins, ras-Related --- GTP Binding Proteins, Monomeric --- GTP-Binding Proteins, ras-Related --- GTPases, Small --- GTPases, ras-Related --- Monomeric G Proteins --- Monomeric GTP Binding Proteins --- Proteins, ras-Related GTP-Binding --- Small G Proteins --- ras Related G Proteins --- ras Related GTP Binding Proteins --- ras Related GTPases --- Anhydride Hydrolases, Acid --- Hydrolases, Acid Anhydride --- Biochemistry -- Periodicals. --- Biochemistry -- Technique. --- Enzymes -- Collections. --- Enzymes -- Periodicals. --- Enzymologie -- Technique -- Collections. --- GTP Phosphohydrolases. --- GTP phosphohydrolase --- Guanosine triphosphate phosphohydrolase --- GTP phosphohydrolases. --- Cytoplasmic Vesicles --- Physiological effect --- G proteins --- Membrane proteins --- Phosphatases --- Coenzymes and Enzymes --- Biocatalysts --- Molecular Mechanisms of Pharmacological Action --- Protein Binding --- Receptors, Transferrin --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Polypeptides --- Biocatalyst --- Enzyme --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport --- Protein --- Peptide --- Polypeptide --- Hydrolase --- Small GTPase --- GTPase, Small --- rho GTPase --- GTPase, rho --- Gene expression. --- Gtp phosphohydrolases --- Map kinase signaling system --- Adp-ribosylation factors --- Gtp-binding proteins --- Gtp phosphohydrolase activators --- Gtp-binding protein regulators

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The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

Guanosine Triphosphate. --- Rho GTPases. --- rho GTP-Binding Proteins. --- Rho G proteins --- Rho GTP-binding proteins --- Guanosine triphosphatase. --- G proteins --- Guanosine triphosphatase --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- Phosphatases