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This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.

Kallikrein --- Tumors --- Proteolytic enzymes --- Peptide hydrolases --- Proteases --- Hydrolases --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Padutin --- Vascormone --- Pancreas --- Serine proteinases --- Genetics. --- Metabolism. --- Secretions --- Molecular biology --- Oncology. Neoplasms --- Biochemistry. --- Kallikrein. --- Pathophysiology. --- Peptidase. --- Physiology.

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Angiotensins --- Enzyme activation --- Kallikrein --- Kinins --- Renin --- Enzyme Activation --- Kallikreins --- Peptides --- Angiotensin --- Neuropeptides --- Oligopeptides --- Peptide hormones --- Aspartic proteinases --- Juxtaglomerular apparatus --- Hypotensive agents --- Inflammation --- Polypeptides --- Vasodilators --- Padutin --- Vascormone --- Pancreas --- Serine proteinases --- Activation, Enzyme --- Enzymes --- Big Renin --- Cryorenin --- Inactive Renin --- Pre-Prorenin --- Preprorenin --- Prorenin --- Angiotensin-Forming Enzyme --- Angiotensinogenase --- Angiotensin Forming Enzyme --- Pre Prorenin --- Renin, Big --- Renin, Inactive --- Juxtaglomerular Apparatus --- Peptide --- Polypeptide --- Kinin --- Callicrein --- Dilminal --- Kallidinogenase --- Kalliginogenase --- Kallikrein A --- Kallikrein B' --- Kallikrein Light Chain --- Kinin-Forming Enzyme --- alpha-Kallikrein --- beta-Kallikrein --- beta-Kallikrein B --- Kininogenase --- Enzyme, Kinin-Forming --- Kinin Forming Enzyme --- Light Chain, Kallikrein --- alpha Kallikrein --- beta Kallikrein --- beta Kallikrein B --- Activations, Enzyme --- Enzyme Activations --- Enzyme Activators --- Mediators --- Secretions --- Regulation --- Enzymology --- Human biochemistry --- Pharmacology. Therapy --- Pathology of the circulatory system --- Pathological endocrinology