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This volume provides a comprehensive summary of pancreatitis and its complications, with expert recommendations on prediction and management. The text thoughtfully summarizes the current prediction models for severe acute pancreatitis, including laboratory, clinical and imaging parameters, and highlights the relative advantages and disadvantages of several of these models. Evidenced-based guidelines into medical and surgical management of both the hospitalized and discharged patient are described, with recommendations from expert authors pertaining to various clinical situations. The volume also discusses complications of acute pancreatitis and their management, including the use of cutting-edge minimally-invasive therapies. Prediction and Management of Severe Acute Pancreatitis serves as the fundamental source for those interested in and treating this disease, including practicing gastroenterologists, surgeons, radiologists, intensivists, hospitalists and pathologists.

Medicine & Public Health. --- Gastroenterology. --- General Surgery. --- Interventional Radiology. --- Medicine. --- Interventional radiology. --- Surgery. --- Médecine --- Radiologie interventionnelle --- Gastroentérologie --- Chirurgie --- Pancreatitis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pancreatic Diseases --- Digestive System Diseases --- Diseases --- Pancreatitis, Acute Necrotizing --- Diagnosis --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Pancreatitis. --- Pancreas --- Inflammation --- Radiology, Interventional --- Medical radiology --- Therapeutics --- Surgery, Primitive --- Internal medicine --- Digestive organs --- Gastroenterology . --- Interventional radiology .

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Human medicine --- Kinderverlamming --- Syndroom (ziektebeeld) --- Chronische pijn --- Diagnose --- Postpoliomyelitis syndrome --- Poliomyelitis --- Muscular Disorders, Atrophic --- Neurodegenerative Diseases --- Nervous System Diseases --- Myelitis --- Central Nervous System Viral Diseases --- Spinal Cord Diseases --- Muscular Diseases --- Neuromuscular Diseases --- Enterovirus Infections --- Central Nervous System Infections --- Diseases --- Central Nervous System Diseases --- Musculoskeletal Diseases --- Picornaviridae Infections --- Virus Diseases --- RNA Virus Infections --- Postpoliomyelitis Syndrome --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Spinal Cord Disorders --- Myelopathy --- Myelopathies --- Spinal Cord Disease --- Spinal Cord Disorder --- Central Nervous System Viral Infections --- Infections, CNS, Viral --- Infections, Viral CNS --- Viral Infections, Central Nervous System --- CNS Viral Diseases --- Viral Diseases, Central Nervous System --- CNS Infection, Viral --- CNS Infections, Viral --- CNS Viral Disease --- Disease, CNS Viral --- Diseases, CNS Viral --- Infection, Viral CNS --- Viral CNS Infection --- Viral CNS Infections --- Viral Disease, CNS --- Viral Diseases, CNS --- Infectious Myelitis --- Inflammation, Spinal Cord --- Myelopathy, Inflammatory --- Spinal Cord Inflammation --- Subacute Necrotizing Myelitis --- Inflammations, Spinal Cord --- Inflammatory Myelopathies --- Inflammatory Myelopathy --- Myelitides --- Myelitides, Subacute Necrotizing --- Myelitis, Infectious --- Myelitis, Subacute Necrotizing --- Myelopathies, Inflammatory --- Necrotizing Myelitides, Subacute --- Necrotizing Myelitis, Subacute --- Spinal Cord Inflammations --- Subacute Necrotizing Myelitides --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Degenerative Diseases, Central Nervous System --- Degenerative Diseases, Neurologic --- Degenerative Diseases, Spinal Cord --- Degenerative Neurologic Diseases --- Degenerative Neurologic Disorders --- Nervous System Degenerative Diseases --- Neurodegenerative Disorders --- Neurologic Degenerative Conditions --- Neurologic Degenerative Diseases --- Neurologic Diseases, Degenerative --- Degenerative Diseases, Nervous System --- Degenerative Condition, Neurologic --- Degenerative Conditions, Neurologic --- Degenerative Neurologic Disease --- Degenerative Neurologic Disorder --- Neurodegenerative Disease --- Neurodegenerative Disorder --- Neurologic Degenerative Condition --- Neurologic Degenerative Disease --- Neurologic Disease, Degenerative --- Neurologic Disorder, Degenerative --- Neurologic Disorders, Degenerative --- Atrophic Muscular Disorders --- Spinopontine Atrophy --- Atrophy, Disuse --- Atrophy, Spinopontine --- Atrophic Muscular Disorder --- Atrophies, Disuse --- Atrophies, Spinopontine --- Disorder, Atrophic Muscular --- Disorders, Atrophic Muscular --- Disuse Atrophies --- Disuse Atrophy --- Muscular Disorder, Atrophic --- Spinopontine Atrophies --- Muscular Atrophy --- Encephalitis, Polio --- Epidemic Acute Poliomyelitis --- Polio Encephalitis --- Poliomyelitis Infection --- Poliomyelitis, Acute --- Infantile Paralysis --- Polio --- Poliomyelitis, Nonpoliovirus --- Poliomyelitis, Preparalytic --- Acute Poliomyelitis --- Acute Poliomyelitis, Epidemic --- Infection, Poliomyelitis --- Infections, Poliomyelitis --- Nonpoliovirus Poliomyelitis --- Paralysis, Infantile --- Poliomyelitides, Preparalytic --- Poliomyelitis Infections --- Poliomyelitis, Epidemic Acute --- Polios --- Preparalytic Poliomyelitis --- Post-polio syndrome --- Postpolio syndrome --- Postpoliomyelitis muscular atrophy --- Muscular atrophy --- Syndromes --- Post-Poliomyelitis Muscular Atrophy --- Muscular Atrophy, Postpoliomyelitis --- Post-Polio Syndrome --- Post-Poliomyelitis Syndrome --- Postpoliomyelitis Muscular Atrophy --- Muscular Atrophies, Post-Poliomyelitis --- Muscular Atrophies, Postpoliomyelitis --- Muscular Atrophy, Post-Poliomyelitis --- Post Poliomyelitis Muscular Atrophy --- Post Poliomyelitis Syndrome --- Post-Polio Syndromes --- Post-Poliomyelitis Muscular Atrophies --- Postpoliomyelitis Muscular Atrophies --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Infections, Picornaviridae --- Infections, Picornavirus --- Picornavirus Infections --- Infection, Picornaviridae --- Infection, Picornavirus --- Picornaviridae Infection --- Picornavirus Infection --- Orthopedic Disorders --- Musculoskeletal Disease --- Orthopedic Disorder --- CNS Diseases --- Central Nervous System Disorders --- CNS Disease --- Central Nervous System Disease --- Central Nervous System Disorder --- Central Nervous System Infection --- Infections, Central Nervous System --- CNS Infections --- CNS Infection --- Infection, CNS --- Infections, CNS --- Infections, Enterovirus --- Enterovirus Infection --- Infection, Enterovirus --- Cramp-Fasciculation Syndrome --- Fasciculation-Cramp Syndrome, Benign --- Foley-Denny-Brown Syndrome --- Oppenheim's Disease --- Amyotonia Congenita --- Oppenheim Disease --- Benign Fasciculation-Cramp Syndrome --- Benign Fasciculation-Cramp Syndromes --- Cramp Fasciculation Syndrome --- Cramp-Fasciculation Syndromes --- Fasciculation Cramp Syndrome, Benign --- Fasciculation-Cramp Syndromes, Benign --- Foley Denny Brown Syndrome --- Neuromuscular Disease --- Oppenheims Disease --- Syndrome, Cramp-Fasciculation --- Syndrome, Foley-Denny-Brown --- Syndromes, Cramp-Fasciculation --- Myopathic Conditions --- Muscle Disorders --- Myopathies --- Muscle Disorder --- Muscular Disease --- Myopathic Condition --- Myopathy --- Complications

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This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

donor breast milk --- human milk --- milk analysis --- very low birth weight --- preterm --- growth --- preterm infant --- donor human milk --- formula feeding --- breastfeeding --- necrotizing enterocolitis --- breast milk --- prematurity --- immunity --- newborn --- inflammation --- colostrum administration --- premature neonates --- clinical outcomes --- intestinal resection --- short bowel syndrome --- intestinal adaptation --- microbiome --- parenteral nutrition --- hormones --- milk fat globule --- long chain polyunsaturated fatty acids --- premature infants --- neonatal --- intestine --- glycosaminoglycans --- intestinal inflammation --- bioactive --- donor milk --- gastroschisis --- intestinal atresia --- human milk fortifier --- patient empowerment --- neonatal nutrition --- communication --- product labeling --- NICU parent --- extracellular vesicle --- exosome --- immature intestine --- formula --- osmolality --- breastmilk --- late onset sepsis --- bloodstream infections --- enteric pathogens --- human milk banks --- NEC --- meta-analysis --- breast-feeding --- spontaneous intestinal perforation --- feeding --- nutrition

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The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

minerals --- cancer treatment --- chitosan --- n/a --- neurodegeneration --- antioxidant activity --- senescence --- tumor proliferation --- nanoparticles --- antimicrobial agents --- oxidative metabolites --- drug discovery --- Akt/mTOR signaling --- micronutrients --- ulcerative colitis --- transmission electron microscopy --- metabolic reprogramming --- curcumin --- death receptor --- chaperone-mediated autophagy --- wound healing --- brain ischemia --- autophagy --- Alzheimer’s disease --- genes --- transthyretin --- inflammatory bowel disease --- cellular pathway --- centrifugal partition chromatography --- nutrition --- amyloid --- Curcuma longa --- protein aggregation --- supportive care --- IL-17 --- senolytics --- complementary medicine --- macronutrients --- structure activity relationship --- gastroprotection --- Zingiberaceae --- anti-inflamation --- TLC bioautography --- microbiota --- glioblastoma multiforme --- amyloidosis --- SHMT2 --- antioxidants --- silica --- apoptosis --- reflux esophagitis --- gastric ulcer --- TLC-MS --- anti-cancer --- anticancer --- ImageJ --- anti-tumor --- delivery system --- wound --- Helicobacter pylori --- direct protein binding --- protein misfolding --- tumor growth --- diet --- Crohn’s disease --- hydrostatic counter-current chromatography --- ageing --- renal cell cancer --- gastric cancer --- amino-acids --- STAT3 --- mechanism of action --- inflamm-aging --- mitophagy --- necrotizing enterocolitis --- cell cycling --- vitamins --- turmeric tuber --- cancer --- tau protein --- Alzheimer's disease --- Crohn's disease

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We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis—called dysbiosis—has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors

Bacteroides ovatus --- Bifidobacterium adolescentis --- Dysbiosis --- Faecalibacterium prausnitzii --- Ruminococcus gnavus --- type 1 diabetes --- microbiota --- microbiome --- auto-immunity --- gut permeability --- gut --- IBS --- celiac disease --- enteropathy --- gluten --- therapy --- gut microbiota --- precision medicine --- Clostridium difficile --- inflammatory bowel disease --- ulcerative colitis --- irritable bowel disease --- metabolic syndrome --- gastric microbiota --- transient --- persistent --- culture --- sequencing --- Helicobacter pylori --- fecal microbiota transplantation --- feces donor --- fecal microbiota --- flow cytometry --- viability of bacteria --- next-generation sequencing --- culturing of fecal microbiota --- Alzheimer’s disease --- microbiota–gut–brain axis --- neurodegenerative disease --- intestinal flora --- necrotizing enterocolitis --- intestinal microbiology --- infant gut --- metabolomics --- IL-6 --- IL-8 --- IL-12p70 --- intestinal permeability --- zonulin --- gut virome --- steatosis --- cirrhosis --- hepatocellular carcinoma --- gastrointestinal --- technology --- high-throughput --- crohn’s disease --- mononuclear cells --- transient receptor potential channel --- pancreatic diseases --- acute pancreatitis --- chronic pancreatitis --- diabetes mellitus --- pancreatic ductal adenocarcinoma --- pancreatic cystic neoplasms