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Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.

Protein folding.

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Protein folding. --- Protein Folding. --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Folding of proteins --- Proteins --- Folding --- Conformation

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One of the great unsolved problems of science and also of physics is the prediction of the three dimensional structure of a protein from its amino acid sequence. It may be stated that the deep connection existing between physics and protein folding is not so much, or in any case not only, through physical methods, but through physical concepts.

Drugs --- Protein folding --- Folding of proteins --- Proteins --- Design --- Folding --- Conformation --- Drug design

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This book introduces an approach to protein folding from the point ofview of kinetic theory. There is an abundance of data on proteinfolding, but few proposals are available on the mechanism driving theprocess. Here, presented for the first time, are suggestions onpossible research directions, as developed by the author incollaboration with C C Lin.

Statistical physics. --- Protein folding. --- Folding of proteins --- Proteins --- Physics --- Mathematical statistics --- Folding --- Conformation --- Statistical methods

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Folding cycles --- Electric bicycles --- Bicycles --- Transportation --- Purchasing