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The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Endothelium --- Diseases. --- Epithelium --- Medicine --- Cardiology and Cardiovascular Medicine --- Health Sciences

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This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.

Cytology. --- Cancer. --- Inflammation. --- Autoimmunity. --- Cell Biology. --- Cancer Biology. --- Endothelium --- Epithelium --- Junctional complexes (Epithelium) --- Tight junctions (Cell biology) --- Tumors. --- Tight Junctions. --- Tight Junction Proteins --- Neoplasms. --- Autoimmunity

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Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and

Mucous membrane --- Immunology. --- Mucosa --- Mucosal tissue --- Tunica mucosa --- Epithelium --- Membranes (Biology)

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Preface It was indeed a great pleasure and honor for me to have hosted the 9th International Conference on Cholesteatoma and Ear Surgery in Nagasaki, Japan. There were 558 participants; four full-day programs provided them with rich scientific programs including six keynote lectures, seven symposia, 26 panel discussions, 12 mini lectures on recent topics, 23 instruction courses, two live cadaver temporal-bone dissections, three sponsored sessions, three other sessions, and three days of temporal-bone dissection courses. I would like to take this opportunity to express my greatest gratitude to a

Cholesteatoma --- Ear --- Auditory system --- Head --- Sense organs --- Hearing --- Pearly tumor --- Cysts (Pathology) --- Epithelium --- Surgery --- Tumors

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Cell adhesion --- Adherence, Cell --- Cell adherence --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Cell adhesion.