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This textbook gives an account of the accomplishments related to the development of 99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of 99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered. Section 1 contains basic principles and methods used for analysis. Special emphasis is given to the analytical methods verifying pharmaceutical quality. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affection in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients. This book can serve for daily practice in nuclear medicine, serving as a reference source as well as a teaching tool.

Technetium. --- Nuclear medicine. --- Radiopharmaceuticals. --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Radioactive tracers --- Radioactivity --- Radiopharmaceutical agents --- Pharmacology --- Eka-manganese --- Ekamanganese --- Masurium --- Nipponium --- Manganese group --- Radioactive substances --- Physiological effect --- Radiology, Medical. --- Imaging / Radiology. --- Nuclear Medicine. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiology. --- Radiological physics --- Physics --- Radiation

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99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that was introduced into clinical routine for myocardial perfusion imaging more than two decades ago. Although today the main application of 99mTc-sestamibi SPECT remains the imaging of myocardial perfusion, it is also an accepted and well-proven imaging technique for a variety of oncologic and non-oncologic applications, including brain, breast, and thyroid cancer and thyroid and parathyroid adenoma. Its efficacy in a range of indications ensures that 99mTc-sestamibi SPECT will remain widely used despite the rapid diffusion of 18F-FDG PET.                         99mTc-Sestamibi – Clinical Applications provides a detailed and informative overview of almost all the oncologic and non-oncologic applications of 99mTc-sestamibi SPECT, including several relatively rare indications. Different disease-related protocols for 99mTc-sestamibi SPECT are presented, and for each disease a comprehensive summary of the relevant pathology and epidemiology is provided. Throughout, there is a strong emphasis on the practical aspects of use of this popular tracer, including instructions for the preparation of several commercially available tracer kits. Clinical practitioners will find this book to be an invaluable guide to the application and benefits of 99mTc-sestamibi SPECT in both the inpatient and the outpatient setting.

Cardiology. --- Magnetic resonance imaging. --- Nuclear medicine. --- Oncology. --- Radiology, Medical. --- Single-photon emission computed tomography --- Diagnostic Techniques, Radioisotope --- Organotechnetium Compounds --- Diagnostic Imaging --- Investigative Techniques --- Nitriles --- Organometallic Compounds --- Diagnostic Techniques and Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Organic Chemicals --- Diagnosis --- Inorganic Chemicals --- Chemicals and Drugs --- Technetium Tc 99m Sestamibi --- Methods --- Radionuclide Imaging --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Technetium --- Radioisotope scanning. --- Radioisotopes in medical diagnosis. --- Isotopes. --- Diagnostic radioisotopes --- Radiodiagnosis --- Radioisotopes --- Radioisotope scintigraphy --- Radionuclide imaging --- Scintigraphy, Radioisotope --- Diagnostic use --- Medicine. --- Radiology. --- Medicine & Public Health. --- Nuclear Medicine. --- Imaging / Radiology. --- Diagnostic imaging --- Radioactive tracers --- Radioactivity --- Radioisotopes in medical diagnosis --- Scanning systems --- Nuclear medicine --- Measurement --- Oncology  . --- Tumors --- Heart --- Internal medicine --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Diseases --- Physiological effect --- Radiological physics --- Physics --- Radiation

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The focus of this Special Issue is aimed at enhancing the discussion of Engineering Education, particularly related to technological and professional learning. In the 21st century, students face a challenging demand: they are expected to have the best scientific expertise, but also highly developed social skills and qualities like teamwork, creativity, communication, or leadership. Even though students and teachers are becoming more aware of this necessity, there is still a gap between academic life and the professional world. In this Special Edition Book, the reader can find works tackling interesting topics such as educational resources addressing students’ development of competencies, the importance of final year projects linked to professional environments, and multicultural or interdisciplinary challenges.

thick target yield --- 52Mn --- radioisotope production --- magnetron sputtering --- thorium --- theranostics --- molecular sieve desiccant --- medical radioisotope production --- vortex target --- radioisotope target processing --- gamma spectroscopy --- solid --- azeotropic mixtures --- disposable kit --- filament --- targetry --- radiopharmaceuticals --- medical cyclotrons --- unconventional radionuclides --- radioisotope targetry --- thermal study --- recycling of [18O]-water --- medical radioisotopes --- powder target --- metal 3D-printing --- medical cyclotron --- cyclotron --- stacked-foils --- copper-64 --- stack-foil --- targets --- SPECT --- monitor reaction --- purification --- numerical analysis --- carbon-11 --- copper-61 --- boron nitride nanotubes --- radiometals --- radioactive impurities --- solid target system --- Ga-68 --- BNNTs --- spallation --- recoil escape --- cyclotron target --- target stations --- 70 MeV cyclotron --- irradiation --- liquid targets --- target temperature --- separation --- solid target --- enrichment grade --- Molybdenum-100 --- cyclotron solid target --- radionuclides --- ion accelerator --- heavy Rare Earth Elements (hREE) --- molybdenum material recovery --- beam energy --- cyclotrons --- resin --- medical isotopes --- target chemistry --- solid radioisotope targets --- 165Er --- targeted alpha therapy --- gallium-68 --- radionuclide production --- titanium-45 --- medical Sc radioisotopes --- radioisotopes --- liquid and gas targets --- ion source --- actinium-225 --- ANSYS --- cross-section reconstruction --- thick target yield measurements --- cross-section --- Technetium-99m --- fractional distillation --- Radionuclide Yield Calculator --- Gallium-68 --- proton target --- PET --- thick film deposition