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Pediatric Endodontics : Current Concepts in Pulp Therapy for Primary and Young Permanent Teeth
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ISBN: 9783319275536 3319275534 3319275518 Year: 2016 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book provides dental professionals with a clear understanding of current clinical and scientific knowledge on the various aspects of pulp treatment for both primary and young permanent teeth. Diagnostic parameters are clearly presented, along with step-by-step descriptions of clinical procedures, including indirect and direct pulp treatments, pulpotomy, and pulpectomy. The rationale for the materials used in each technique and their individual merits and disadvantages are examined in detail. In the case of pulpotomy, all the materials used since the introduction of this treatment modality are discussed (e.g., formocresol, glutaraldehyde, ferric sulfate, and MTA) and the roles of sodium hypochlorite, electrofulguration, and laser therapy are elucidated. Special attention is devoted to pulpectomy and root canal treatment, with consideration of debriding and obturation techniques, rinsing solutions, and root-filling pastes. A further individual chapter is dedicated to restorations of teeth treated with the different types of pulp therapy. The various conservative treatment modalities are also presented, including specific treatments for immature nonvital permanent teeth. The concluding chapter looks to the future and the potential value of stem cells in pulp therapy.


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Squamous cell Carcinoma : Molecular Therapeutic Targets
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ISBN: 9789402410846 9402410848 940241083X Year: 2017 Publisher: Dordrecht : Springer Netherlands : Imprint: Springer,

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This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.


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Atlas of geriatric dermatology
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ISBN: 9781447145790 1447145798 Year: 2014 Publisher: London ; New York : Springer,

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This is a comprehensive, practical, densely illustrated diagnostic and therapeutic guide for all geriatric dermatology providers. The book comprises 50 chapters and over 600 color photographs on topics ranging from common conditions such as basal cell carcinoma, rosacea, and seborrheic dermatitis to unusual conditions such as angiosarcoma, dermatofibrosarcoma protuberans, and porphyria cutanea tarda. Sections include: - Inflammatory conditions (including contact dermatitis, alopecia, erythema multiforme, pemphigus, bullous pemphigoid, porphyria, pruritus, psoriasis, rosacea, seborrhea, urticaria, xerosis, and more) - Infections (fungus, herpes simplex and zoster, scabies, lice, and warts) - Skin signs in systemic disease (skin tags, cutaneous metastases, xanthomas) - Regional dermatoses (intertrigo, leg ulcers, pressure sores) - Benign tumors (chondrodermatitis, cysts, ganglion, fibrous papule, seborrheic keratoses, lentigines, and benign vascular lesions) - Pre-malignant and malignant tumors (actinic keratoses, angiosarcoma, basal cell carcinoma, dermatofibroma and dermatofibrosarcoma protuberans, intraepidermal neoplasia, Kaposi's sarcoma, keratoacanthoma, lentigo maligna, cutaneous lymphoma, Mycosis fiungoides, melanoma, nevi and moles, and squamous cell carcinoma).


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Classic papers in orthopaedics
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ISBN: 9781447154518 1447154517 Year: 2014 Publisher: London : Springer,

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The book categorizes articles by field of research to include studies on the hip and knee arthroplasty, sports medicine and arthroscopy, paediatric orthopaedics foot and ankle, spine, hand and upper extremity, trauma/fracture healing, oncology and basic science articles (stem cell, bone tissue, ligament, tendon tissue and implants).   Classic Papers in Orthopaedics assembles a distinguished team of contributors to identify, analyze and bring together in a single volume the most important articles from a broad range of publications that have become recognized as the defining articles in orthopaedics. It is a unique reference providing a single source for reviewing the most important papers in the discipline. It also provides a critical analysis of the strengths, weaknesses and the impact each paper has had on the development of orthopaedics and is therefore essential reading for all practicing orthopaedic surgeons, orthopaedic trainees sitting higher level exams, and all involved in research and clinical practice in the field of orthopaedics.


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Stem cells handbook
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ISBN: 9781461476962 1461476968 Year: 2013 Publisher: New York : Springer Science,

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Stem Cells Handbook, second edition, emphasizes the advances in understanding and working with embryonic and fetal stem cells as well as induced pluripotent stem cells that show the most promise for clinical use. This new edition has been completely rewritten and updated to reflect the significant advances made in this field since publication of the first edition in 2004. The thirty-six chapters in this book – all written by recognized experts in Stem Cell research – reflect the tremendous progress in the understanding of stem cell biology and the appreciation of the potential for using stem cells for therapy of cancer, aging, injury and congenital diseases. Arguably the biggest advances have been made in obtaining different populations of stem cells, inducing mature cells to act like stem cells, and the ever-critical issue of how to get these stem cells to expand and differentiate into the tissue precursor cells that then can be used to replace lost of damaged tissues. No less exciting are the recent advances in understanding how stem cells function to maintain tissue integrity and how to use this knowledge to prevent developmental abnormalities. Other key topics discussed include: properties of tissue stem cells , transplantation of stem cells, the stem cell as a target for cancer treatment and prevention.


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Craft in Biomedical Research : The iPS Cell Technology and the Future of Stem Cell Science
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ISBN: 9781137475527 9781137469106 1137469102 Year: 2018 Publisher: New York : Palgrave Macmillan US : Imprint: Palgrave Macmillan,

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This book explores the new ways in which biology is becoming technology. The revolutionary iPS cell technology has made it possible to turn human skin and blood cells into pluripotent stem cells, thus providing an unprecedented opportunity to study the pathophysiology of diseases, understand human developmental biology, and generate new therapies. Drawing from a rich ethnographic study, Meskus traces the making of the iPS cell technology through the perspectives of clinical translation, laboratory experimentation, and tissue donation by voluntary patients. Discussing non-human agency, the embodied and affective basis of knowledge production, and the material politics of science, the book develops the idea of an instrumentality-care continuum as a fundamental dynamic of biomedical craft. This continuum, Meskus argues, opens up a novel perspective to the commercialization and industrial-scale appropriation of human biology, and thereby to the future of ethical biomedical research. .


Book
Hematologie.
Authors: ---
ISBN: 9789031399055 9789031399062 Year: 2013 Publisher: Houten Bohn Stafleu van Loghum

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In deze uitgave worden alle hematologische maligniteiten besproken inclusief de nieuwe therapeutische mogelijkheden met een update van de zorg rond stamceltransplantaties. Alle belangrijke aspecten van de niet-maligne hematologie, zoals bloedarmoede, transfusiebeleid, bloedings- en stollingsziekten komen uitgebreid aan bod. Nieuw toegevoegd is het hoofdstuk over immunologie en een fraai overzicht van - in de hemalogie toegepaste - chemotherapie en immunotherapie. Het slothoofdstuk (Algemene verpleegkundige aandachtspunten) is volledig herschreven en aangepast aan de moderne inzichten in de verpleegkundige zorg op het gebied van hematologie.


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Trends in stem cell proliferation and cancer research
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ISBN: 9789400762114 9400762119 Year: 2013 Publisher: Dordrecht ; New York : Springer,

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance.


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Etiology and Morphogenesis of Congenital Heart Disease : From Gene Function and Cellular Interaction to Morphology
Authors: --- --- --- --- --- et al.
ISBN: 9784431546283 4431546286 Year: 2016 Publisher: Tokyo : Springer Japan : Imprint: Springer,

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This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Biotechnology for beginners
Authors: --- --- --- --- --- et al.
ISBN: 9780123735812 9780128012734 0128012730 0128012242 9780128012246 0123735815 Year: 2017 Publisher: London : Academic Press,

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This book presents the latest information and developments from the field of biotechnology, offering an exciting and colorful overview of biotechnology for professionals and students in a wide array of the life sciences, including genetics, immunology, biochemistry, agronomy, and animal science.

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