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Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.

Cytokines. --- Cytokines--Handbooks, manuals, etc. Cytokines--outlines. --- Receptors, Immunologic --- Intercellular Signaling Peptides and Proteins --- Proteins --- Receptors, Cell Surface --- Biological Factors --- Peptides --- Amino Acids, Peptides, and Proteins --- Membrane Proteins --- Chemicals and Drugs --- Cytokines --- Receptors, Cytokine --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Cellular immunity --- Immune response --- Regulation --- Receptors, cytokine

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The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.

T cells. --- T cells Receptors--Handbooks, manuals, etc. T-cell receptor genes--Handbooks, manuals, etc. --- T-cell receptor genes. --- Receptors, Antigen, T-Cell --- Genes, T-Cell Receptor --- Genes --- Receptors, Antigen --- Genome Components --- Receptors, Immunologic --- Receptors, Cell Surface --- Genome --- Membrane Proteins --- Genetic Structures --- Proteins --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- T cells --- T-cell receptor genes --- Receptors --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Lymphocytes

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Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Cancer cells --- Chemokines --- Receptors, Cytokine --- Antigens, CD --- Receptors, G-Protein-Coupled --- Diseases --- Angiogenesis Modulating Agents --- Growth Substances --- Receptors, Immunologic --- Antigens, Differentiation --- Receptors, Cell Surface --- Membrane Proteins --- Biological Markers --- Antigens, Surface --- Physiological Effects of Drugs --- Pharmacologic Actions --- Proteins --- Antigens --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Angiogenesis Inducing Agents --- Neoplasms --- Receptors, Chemokine --- Biology --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Oncology --- Microbiology & Immunology --- Growth --- Regulation. --- Receptors --- Effect of drugs on. --- Effect of drugs on --- Regulation --- Chemokines. --- Drug receptors. --- Drugs --- Receptors, Drug --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Cell receptors --- Cytokines --- Inflammation --- Peptides --- Mediators --- Oncology  . --- Tumors --- Cancer research

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Allergy and Immunology --- Immunotherapy, Active --- HLA-D Antigens --- Immunologic Techniques --- Immunologic Tests --- Receptors, Immunologic --- Immunodiagnosis --- Diagnostics immunologiques --- Periodicals. --- Périodiques --- Immunodiagnosis. --- Allergy and Immunology. --- Immunotherapy, Active. --- HLA-D Antigens. --- Immunologic Techniques. --- Immunologic Tests. --- Receptors, Immunologic. --- Science --- Immunologic Receptor --- Immunological Receptors --- Immunologic Receptors --- Receptor, Immunologic --- Receptors, Immunological --- Diagnosis, Immunologic --- Immunologic Diagnosis --- Immunologic Test --- Immunological Tests --- Tests, Immunologic --- Diagnosis, Immunological --- Diagnoses, Immunologic --- Diagnoses, Immunological --- Immunodiagnoses --- Immunologic Diagnoses --- Immunological Diagnoses --- Immunological Diagnosis --- Immunological Test --- Test, Immunologic --- Test, Immunological --- Tests, Immunological --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- HLA-D --- HLA-Dw --- Immune Response Associated Antigens, Human --- Antigens, HLA-D --- Class II Human Antigens --- HLA-Dw Antigens --- Human Class II Antigens --- Ia-Like Antigens, Human --- Immune Response-Associated Antigens, Human --- Immune-Associated Antigens, Human --- Immune-Response Antigens, Human --- Antigens, HLA D --- Antigens, HLA-Dw --- Antigens, Human Ia-Like --- Antigens, Human Immune-Associated --- Antigens, Human Immune-Response --- HLA D Antigens --- HLA Dw Antigens --- Human Ia-Like Antigens --- Human Immune-Associated Antigens --- Human Immune-Response Antigens --- Ia Like Antigens, Human --- Immune Associated Antigens, Human --- Immune Response Antigens, Human --- Active Immunotherapy --- Therapy, Vaccine --- Immune RNA Manipulation --- Vaccine Therapy --- Active Immunotherapies --- Immune RNA Manipulations --- Immunotherapies, Active --- Manipulation, Immune RNA --- Manipulations, Immune RNA --- RNA Manipulation, Immune --- RNA Manipulations, Immune --- Therapies, Vaccine --- Vaccine Therapies --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- Immunological diagnosis --- methods --- Immunity --- Immunochemistry --- Clinical immunology --- Diagnosis, Laboratory --- Immunoassay

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Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death