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Emerging infectious diseases --- -Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- MEDICAL --- Emerging infections

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Almost exactly ten years ago, two young physicians joined me at the University of Oklahoma for the study of dermatopathology: Stephen C. Somach, a brilliant dermatologist-scholar from Cleveland, who was also a highly accomplished cellist, and Michael B. Morgan, an effervescent, newly minted pathologist from Florida, who was brimming with energy, curiosity, and zeal and was also spo- ing water skiis and a red Porsche! Bruce R. Smoller, whose impressive erudition is universally acknowledged, I met during a Residency Review committee visit to Stanford some ?fteen years ago. Each of these men has made original cont- butions to the dermatopathology literature as well as to patient care in the cli- cal setting. Their publications have broadened our understanding of the biologic behavior of pigmented lesions, cutaneous lymphomas, vascular lesions, and soft tissue tumors. It is indeed a pleasure to welcome their volume, Deadly Der- tologic Diseases, a unique and stimulating outcome of their enthusiastic collaboration. Deadly Dermatologic Diseases discusses a wide variety of entities–neoplastic, vascular, infectious, metabolic–each of which may eventuate in death of the patient. In addition, numerous tumors and dermatoses frequently associated with internal malignancies are reviewed. High-quality histologic photomic- graphs and clinical pictures accompany many of the discussions. A unique initial summary page facilitates the reading of each presentation. Recent relevant genetic and biochemical ? ndings in every chapter were particularly helpful to this reader.

Skin --- Diseases. --- Histopathology. --- Cutaneous diseases --- Dermatoses --- Dermatology --- Dermatology. --- Pathology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Infectious diseases.

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As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases.  The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects.   Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It  elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.

Skin --- Diseases. --- Cutaneous diseases --- Dermatoses --- Dermatology --- Dermatology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Diseases --- Infectious diseases.

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The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway. Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.

Bacterial genetics --- Research --- Safety measures. --- Research. --- Bacteria --- Bacteriology --- Microbial genetics --- Genetics --- Bacteriology. --- Immunology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Microbiology --- Infectious diseases.

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This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.

Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Immunology. --- Dermatology. --- Emerging infectious diseases. --- Infectious Diseases. --- Medicine --- Skin --- Immunobiology --- Life sciences --- Serology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Diseases --- Infectious diseases.