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Deals with developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, and pharmacogenomics and proteomics in oncoendocrinology.

Biomedicine. --- Cancer Research. --- Medicine. --- Oncology. --- Médecine --- Cancérologie --- Breast Neoplasms -- drug therapy. --- Breast Neoplasms -- physiopathology. --- Cancer -- Endocrine aspects. --- Estrogen Receptor Modulators -- pharmacology. --- Receptors, Estrogen -- physiology. --- Receptors, Progesterone -- physiology. --- Cancer --- Estrogen Receptor Modulators --- Receptors, Estrogen --- Breast Neoplasms --- Drug Therapy --- Receptors, Progesterone --- Pharmacology --- Physiology --- Receptors, Steroid --- Hormone Antagonists --- Breast Diseases --- Biological Science Disciplines --- Therapeutics --- Neoplasms by Site --- Skin Diseases --- Receptors, Cytoplasmic and Nuclear --- Neoplasms --- Natural Science Disciplines --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Transcription Factors --- DNA-Binding Proteins --- Disciplines and Occupations --- Physiological Effects of Drugs --- Skin and Connective Tissue Diseases --- Proteins --- Diseases --- Chemicals and Drugs --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Oncology --- Medicine --- Health & Biological Sciences --- Endocrine aspects --- Endocrine aspects. --- Cancer endocrinology --- Hormonal aspects of cancer --- Hormonal aspects --- Cancer research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors

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This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800’s, and then awareness reawakened in the 1940’s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Androgens --Physiological effect. --- Androgens --Receptors. --- Prostate --Cancer. --- Prostate --- Androgens --- Genital Neoplasms, Male --- Receptors, Steroid --- Hormones --- Medicine --- Biological Science Disciplines --- Prostatic Diseases --- Urogenital Neoplasms --- Receptors, Cytoplasmic and Nuclear --- Natural Science Disciplines --- Genital Diseases, Male --- Health Occupations --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Male Urogenital Diseases --- Transcription Factors --- Disciplines and Occupations --- Physiological Effects of Drugs --- Proteins --- Neoplasms by Site --- DNA-Binding Proteins --- Diseases --- Amino Acids, Peptides, and Proteins --- Neoplasms --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Prostatic Neoplasms --- Pathology --- Receptors, Androgen --- Physiology --- Health & Biological Sciences --- Oncology --- Cancer --- Receptors --- Physiological effect --- Generative organs, Male --- Cancer. --- Medicine. --- Cancer research. --- Human genetics. --- Immunology. --- Medical microbiology. --- Pharmacology. --- Virology. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Cancer in men --- Oncology. --- Microbiology. --- Toxicology. --- Medical virology. --- Medical microbiology --- Virology --- Virus diseases --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Toxicology --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research

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Rapid actions of sex steroids play a critical role in mediating the biological outcome of target tissues. This book reviews the importance of these non-genomic effects in initiation and progression of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers.

Breast -- Cancer -- Chemotherapy. --- Hormones, Sex -- Carcinogenicity. --- Hormones, Sex -- Receptors. --- Prostate -- Cancer -- Chemotherapy. --- Steroid hormones -- Therapeutic use. --- Hormones, Sex --- Breast --- Prostate --- Prostatic Diseases --- Gonadal Hormones --- Breast Diseases --- Genital Neoplasms, Male --- Receptors, Cytoplasmic and Nuclear --- Neoplasms by Site --- Therapeutics --- Urogenital Neoplasms --- Hormones --- Proteins --- Neoplasms --- Transcription Factors --- DNA-Binding Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genital Diseases, Male --- Skin Diseases --- Diseases --- Male Urogenital Diseases --- Amino Acids, Peptides, and Proteins --- Skin and Connective Tissue Diseases --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Breast Neoplasms --- Prostatic Neoplasms --- Drug Therapy --- Gonadal Steroid Hormones --- Receptors, Steroid --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Physiological effect --- Cancer --- Endocrine aspects --- Hormones, Sex. --- Steroid hormones. --- Sex factors. --- Treatment. --- Hormonal steroids --- Female sex hormone --- Male sex hormone --- Sex hormones --- Sex differences --- Medicine. --- Cancer research. --- Endocrinology. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Steroids --- Steroid hormones